Paradigm Biocapital Advisors LP : Portfolio Holdings

Portfolio Summary	View Filing
Filing Report Date :	2025-03-31
Total Value :	$2,172,398,000
Total Value Change :	$-701,692,000
Securities Held Change :	-1

All Securities Held :	27
New Positions :	5
Closed Positions :	6
Increased Positions :	11
Unchanged Positions :	1
Decreased Positions :	10

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Holdings Found : 33		View All Holdings	Currently Viewing: ALL				Page 1 of 1

Menu	Ticker	Company Name	Position Rank	New/Closed Postion	Last Close	Value	Shares Held	% of Portfolio	Value Change	Change In Shares Held	% of Company	Industry
	NUVL	Nuvalent, Inc.	1	-	$0.00	$373,708,000	5,269,433	17.2%	-46,137,000	-93,946	7.528	N/A
	ACLX	Arcellx, Inc.	2	-	$0.00	$294,677,000	4,492,032	13.56%	-40,581,000	120,431	8.356	N/A
	RVMD	Revolution Medicines, Inc.	3	-	$36.91	$218,458,000	6,178,111	10.06%	-68,175,000	-375,000	3.634	N/A
	BGNE	Beigene Ltd	4	-	$241.20	$181,272,000	666,024	8.34%	67,486,000	50,000	0.735	N/A
	MRUS	Merus Nv	5	-	$52.99	$141,831,000	3,369,699	6.53%	70,770,000	1,679,777	4.705	N/A
	TARS	Tarsus Pharmaceuticals, Inc.	6	-	$0.00	$134,086,000	2,610,197	6.17%	-6,105,000	78,301	5.893	N/A
	EWTX	Edgewise Therapeutics, Inc.	7	-	$13.17	$96,680,000	4,394,556	4.45%	-23,308,000	-99,373	4.26	N/A
	JANX	Janux Therapeutics, Inc.	8	-	$0.00	$89,908,000	3,329,909	4.14%	-98,338,000	-186,077	6.384	N/A
	CRNX	Crinetics Pharmaceuticals, ...	9	-	$29.96	$65,274,000	1,946,168	3%	-32,423,000	35,407	2.115	N/A
	PCVX	Vaxcyte, Inc.	10	-	$0.00	$64,059,000	1,696,481	2.95%	-52,410,000	273,694	1.243	N/A
	IRON	Disc Medicine, Inc	11	-	$54.50	$60,113,000	1,210,971	2.77%	-34,842,000	-286,749	4.073	N/A
	COGT	Cogent Biosciences, Inc.	12	-	$7.10	$53,692,000	8,963,655	2.47%	15,336,000	4,046,243	6.871	N/A
	LENZ	Lenz Therapeutics	13	-	$30.18	$38,872,000	1,511,932	1.79%	16,629,000	741,477	5.921	N/A
	APGE	Apogee Therapeutics, Inc.	14	-	$43.38	$35,929,000	961,707	1.65%	-22,226,000	-322,059	1.644	N/A
	ARGX	Argenx Se	15	-	$560.14	$35,322,000	59,679	1.63%	-260,681,000	-421,626	0.127	N/A
	CYTK	Cytokinetics Inc	16	New	$33.16	$34,510,000	858,664	1.59%	34,510,000	858,664	0.626	Biotechnology
	INSM	Insmed Inc	17	New	$99.49	$34,434,000	451,359	1.59%	34,434,000	451,359	0.238	Biotechnology
	AGLE	Aeglea Biotherapeutics, Inc.	18	-	$0.60	$34,322,000	2,127,205	1.58%	-1,231,000	600,000	3.478	N/A
	MTSR	Metsera, Inc.	19	New	$28.59	$32,432,000	1,191,462	1.49%	32,432,000	1,191,462	1.134	N/A
	VRDN	Viridian Therapeutics Ors Shs	20	-	$14.33	$28,242,000	2,095,079	1.3%	-6,649,000	275,000	2.328	N/A
	OLMA	Olema Pharmaceuticals, Inc.	21	-	$0.00	$25,347,000	6,741,172	1.17%	-17,241,000	-563,798	11.218	N/A
	MLTX	Multisys Language Solutions...	22	-	$0.00	$24,513,000	627,423	1.13%	-71,452,000	-1,144,788	0.998	N/A
	ARQT	Arcutis Biotherapeutics, Inc.	23	New	$13.74	$22,918,000	1,465,334	1.05%	22,918,000	1,465,334	1.091	N/A
	YMAB	Y-Mabs Therapeutics Inc	24	-	$4.70	$18,767,000	4,236,346	0.86%	-14,404,000	0	10.588	N/A
	ERAS	Erasca, Inc.	25	-	$1.31	$14,799,000	10,802,354	0.68%	-12,189,000	50,000	3.825	N/A
	OCUL	Ocular Therapeutix, Inc	26	New	$0.00	$9,632,000	1,314,018	0.44%	9,632,000	1,314,018	0.843	N/A
	IMTX	Immatics N.V	27	-	$5.43	$8,601,000	1,907,108	0.4%	-29,895,000	-3,507,301	1.85	N/A
	AGIO	Agios Pharmaceuticals Inc	32	Closed	$33.47	$0	0	0%	-9,084,000	-276,439	0	N/A
	SRRK	Scholar Rock Holding Corp	31	Closed	$35.81	$0	0	0%	-17,288,000	-400,000	0	N/A
	VERA	Vera Therapeutics, Inc.	30	Closed	$0.00	$0	0	0%	-60,785,000	-1,437,339	0	N/A
	TECX	Tectonic Therapeutic Inc	29	Closed	$19.80	$0	0	0%	-22,397,000	-485,105	0	N/A
	ORKA	Oruka Therapeutics, Inc	28	Closed	$11.08	$0	0	0%	-15,893,000	-819,660	0	Diagnostic Substances
	PLRX	Pliant Therapeutics, Inc.	33	Closed	$0.00	$0	0	0%	-42,105,000	-3,197,050	0	N/A

33 Records Found

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