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  Name: Frazier Life Sciences Management L.P.
  City: Menlo Park
  State: CA
  Zip: 94025
   
Achive data
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Portfolio Summary View Filing
  Filing Report Date : 2025-03-31
  Total Value : $2,187,909,000
  Total Value Change : $-221,290,000
  Securities Held Change : -3
   
All Securities Held : 47
  New Positions : 4
  Closed Positions : 7
  Increased Positions : 10
  Unchanged Positions : 25
  Decreased Positions : 8

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Holdings Found : 53     View All Holdings Currently Viewing:  ALL     Page 1 of 1
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 Ticker Company Name Position
Rank		 New/Closed
Postion
Last
Close
     Value Shares Held
% of
Portfolio
Value
Change
Change In
Shares Held
    % of Company    Industry
   (NAMS)1 Year Chart         NAMS Newamsterdam Pharma Ord Shs 1 - $0.00 $329,903,000 16,116,418 15.08% -79,149,000 200,000 19.76    N/A
   (MIRM)1 Year Chart         MIRM Mirum Pharmaceuticals, Inc. 2 - $0.00 $306,120,000 6,795,121 13.99% 34,434,000 224,729 12.677    N/A
   (VRNA)1 Year Chart         VRNA Verona Pharma Plc 3 - $0.00 $219,539,000 3,457,850 10.03% 62,388,000 73,900 4.286    N/A
   (ARQT)1 Year Chart         ARQT Arcutis Biotherapeutics, Inc. 4 - $13.74 $137,402,000 8,785,284 6.28% 15,023,000 0 6.542    N/A
   (BBIO)1 Year Chart         BBIO Bridgebio Pharma, Inc. 5 - $44.86 $131,382,000 3,800,457 6% 27,097,000 0 2.185    N/A
   (KRYS)1 Year Chart         KRYS Krystal Biotech Inc 6 - $138.88 $124,129,000 688,460 5.67% 609,000 -100,000 2.396    N/A
   (IRON)1 Year Chart         IRON Disc Medicine, Inc 7 - $54.50 $87,110,000 1,754,834 3.98% -24,146,000 0 5.903    N/A
   (TARS)1 Year Chart         TARS Tarsus Pharmaceuticals, Inc. 8 - $0.00 $71,791,000 1,397,527 3.28% -16,110,000 -190,000 3.155    N/A
   (TRVI)1 Year Chart         TRVI Trevi Therapeutics, Inc. 9 - $0.00 $64,532,000 10,259,409 2.95% 20,593,000 -405,365 10.083    N/A
   (PHAT)1 Year Chart         PHAT Phathom Pharmaceuticals, Inc. 10 - $0.00 $63,385,000 10,109,279 2.9% -18,702,000 0 12.961    N/A
   (KALV)1 Year Chart         KALV Kalvista Pharmaceuticals Inc 11 - $11.41 $56,406,000 4,887,867 2.58% 15,006,000 0 9.33    N/A
   (MAZE)1 Year Chart         MAZE Maze Therapeutics, Inc. 12 New $12.13 $45,460,000 4,129,001 2.08% 45,460,000 4,129,001 9.427    N/A
   (MBX)1 Year Chart         MBX Mbx Biosciences, Inc. 13 - $0.00 $44,172,000 5,985,347 2.02% -66,138,000 0 17.91    N/A
   (RYTM)1 Year Chart         RYTM Rhythm Pharmaceuticals, Inc. 14 - $62.73 $35,954,000 678,760 1.64% -68,718,000 -1,191,048 0.957    N/A
   (SLNO)1 Year Chart         SLNO Soleno Therapeutics Inc 15 - $0.16 $35,665,000 499,159 1.63% 4,238,000 -200,000 0.627    N/A
   (RVMD)1 Year Chart         RVMD Revolution Medicines, Inc. 16 - $36.91 $35,270,000 997,455 1.61% -8,359,000 0 0.587    N/A
   (SVRA)1 Year Chart         SVRA Savara Inc 17 - $2.21 $31,751,000 11,462,301 1.45% 5,164,000 2,801,922 6.964    Biotechnology
   (AGIO)1 Year Chart         AGIO Agios Pharmaceuticals Inc 18 - $33.47 $31,347,000 1,069,854 1.43% -3,805,000 100 1.548    N/A
   (ERAS)1 Year Chart         ERAS Erasca, Inc. 19 - $1.31 $30,929,000 22,575,851 1.41% -17,744,000 3,184,164 7.995    N/A
   (RARE)1 Year Chart         RARE Ultragenyx Pharmaceutical Inc 20 - $36.52 $23,852,000 658,715 1.09% -3,860,000 0 0.715    Restaurants
   (ASND)1 Year Chart         ASND Ascendis Pharma AS 21 - $172.22 $20,781,000 133,333 0.95% 2,425,000 0 0.206    N/A
   (PCVX)1 Year Chart         PCVX Vaxcyte, Inc. 22 - $0.00 $20,368,000 539,405 0.93% -23,788,000 0 0.395    N/A
   (ALKS)1 Year Chart         ALKS Alkermes Plc 23 - $28.81 $19,849,000 601,129 0.91% 2,561,000 0 0.327    Drug Delivery
   (PVLA)1 Year Chart         PVLA Palvella Therapeutics Inc 24 - $22.08 $19,313,000 690,012 0.88% 11,466,000 36,120 52.274    N/A
   (CGON)1 Year Chart         CGON CG Oncology, Inc 25 - $25.95 $18,857,000 770,000 0.86% -3,227,000 0 1.167    N/A
   (MREO)1 Year Chart         MREO Mereo Biopharma Group plc 26 - $2.66 $17,595,000 7,819,863 0.8% -247,000 2,722,084 7.224    N/A
   (MRUS)1 Year Chart         MRUS Merus Nv 27 - $52.99 $15,704,000 373,100 0.72% 15,000 0 0.521    N/A
   (RNA)1 Year Chart         RNA Avidity Biosciences, Inc. 28 New $29.03 $15,498,000 525,000 0.71% 15,498,000 525,000 0.389    N/A
   (HLVX)1 Year Chart         HLVX Hillevax, Inc. 29 - $1.97 $15,395,000 10,617,062 0.7% -6,582,000 0 21.918    N/A
   (DYN)1 Year Chart         DYN Dyne Therapeutics, Inc. 30 New $9.57 $15,097,000 1,443,341 0.69% 15,097,000 1,443,341 1.251    N/A
   (ZLAB)1 Year Chart         ZLAB Zai Lab Ltd 31 New $34.74 $12,649,000 350,000 0.58% 12,649,000 350,000 0.398    N/A
   (IMCR)1 Year Chart         IMCR Immunocore Holdings Adr 32 - $31.12 $8,936,000 301,170 0.41% 5,728,000 192,408 0.602    N/A
   (ORIC)1 Year Chart         ORIC Oric Pharmaceuticals, Inc. 33 - $0.00 $7,869,000 1,410,193 0.36% -23,509,000 -2,478,045 1.999    N/A
   (ACAD)1 Year Chart         ACAD Acadia Pharmaceuticals Inc 34 - $22.12 $7,812,000 470,338 0.36% -819,000 0 0.293    Biotechnology
   (DSGN)1 Year Chart         DSGN Design Therapeutics, Inc. 35 - $0.00 $7,541,000 1,953,547 0.34% -4,512,000 0 3.512    N/A
   (RCKT)1 Year Chart         RCKT Rocket Pharmaceuticals 36 - $2.53 $7,197,000 1,079,025 0.33% -11,394,000 -400,000 1.165    N/A
   (AUTL)1 Year Chart         AUTL Autolus Therapeutics Plc 37 - $2.31 $7,166,000 4,623,324 0.33% -3,699,000 0 1.738    N/A
   (ORKA)1 Year Chart         ORKA Oruka Therapeutics, Inc 38 - $11.08 $5,985,000 583,327 0.27% -5,326,000 0 1.667    Diagnostic Substances
   (ALLO)1 Year Chart         ALLO Allogene Therapeutics, Inc. 39 - $0.00 $5,648,000 3,868,750 0.26% -460,000 1,001,000 1.85    N/A
   (IMTX)1 Year Chart         IMTX Immatics N.V 40 - $5.43 $5,628,000 1,247,911 0.26% -9,644,000 -900,000 1.21    N/A
   (COGT)1 Year Chart         COGT Cogent Biosciences, Inc. 41 - $7.10 $5,610,000 936,576 0.26% -1,695,000 0 0.718    N/A
   (ADVM)1 Year Chart         ADVM Adverum Biotechnologies, Inc 42 - $2.32 $4,673,000 1,069,244 0.21% -320,000 0 1.059    N/A
   (MGNX)1 Year Chart         MGNX Macrogenics Inc 43 - $1.19 $4,033,000 3,175,665 0.18% -6,288,000 0 5.12    Biotechnology
   (LXEO)1 Year Chart         LXEO Lexeo Therapeutics, Inc. 44 - $0.00 $3,316,000 955,515 0.15% -2,971,000 0 0    N/A
   (SLN)1 Year Chart         SLN Silence Therapeutics Adr Re... 45 - $0.00 $3,239,000 1,148,591 0.15% -4,663,000 0 3.853    N/A
   (ELEV)1 Year Chart         ELEV Elevation Oncology, Inc. 46 - $0.36 $1,553,000 5,993,579 0.07% -1,819,000 0 10.14    N/A
   (ETNB)1 Year Chart         ETNB 89bio, Inc. 47 Closed $9.86 $0 0 0% -7,820,000 -1,000,000 0    N/A
   (PLRX)1 Year Chart         PLRX Pliant Therapeutics, Inc. 53 Closed $0.00 $0 0 0% -14,761,000 -1,120,803 0    N/A
   (ANAB)1 Year Chart         ANAB Anaptysbio Inc 52 Closed $22.47 $0 0 0% -20,836,000 -1,573,719 0    N/A
   (ARVN)1 Year Chart         ARVN Arvinas Holding Company, Llc 51 Closed $7.54 $0 0 0% -5,470,000 -285,331 0    N/A
   (DAWN)1 Year Chart         DAWN Day One Biopharmaceuticals,... 50 Closed $0.00 $0 0 0% -8,738,000 -689,655 0    N/A
   (ELDN)1 Year Chart         ELDN Eledon Pharmaceuticals Ord Shs 49 Closed $2.69 $0 0 0% -4,848,000 -1,176,735 0    N/A
   (EWTX)1 Year Chart         EWTX Edgewise Therapeutics, Inc. 48 Closed $13.17 $0 0 0% -33,942,000 -1,271,245 0    N/A
      53 Records Found
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