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  Name: BAKER BROS ADVISORS LLC
  City: NEW YORK
  State: NY
  Zip: 10021
   
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Portfolio Summary View Filing
  Filing Report Date : 2013-12-31
  Total Value : $5,372,160,000
  Total Value Change : $-274,548,000
  Securities Held Change : 9
   
All Securities Held : 83
  New Positions : 23
  Closed Positions : 6
  Increased Positions : 12
  Unchanged Positions : 34
  Decreased Positions : 14
 
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Holdings Found : 11     View All Holdings Currently Viewing:  Increased Positions     Page 1 of 1
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Ticker Company Name Position
Rank
New/Closed
Postion
Last
Close
    Value Shares Held
% of
Portfolio
Value
Change
Change In
Shares Held
   % of Company    Industry
   (SGEN)1 Year Chart         SGEN Seattle Genetics Inc 2 - $36.98 $827,156,000 20,735,926 15.4% -19,769,000 1,412,979 17.109    Biotechnology
   (BMRN)1 Year Chart         BMRN Biomarin Pharmaceutical Inc 8 - $57.37 $136,571,000 1,941,304 2.54% 80,039,000 1,157,993 1.397    Drug Manufacturers - ...
   (QCOR)1 Year Chart         QCOR Questcor Pharmaceuticals Inc 14 - $78.38 $42,246,000 775,864 0.79% 10,587,000 230,018 1.222    Rental & Leasing Serv...
   (CLVS)1 Year Chart         CLVS Clovis Oncology, Inc. 19 - $54.92 $31,988,000 530,738 0.6% 13,642,000 228,994 1.759    Biotechnology
   (AVNR)1 Year Chart         AVNR Avanir Pharmaceuticals 25 - $3.18 $18,240,000 5,428,591 0.34% -493,000 1,000,000 4.371    Drug Manufacturers - ...
   (KYTH)1 Year Chart         KYTH Kythera Biopharmaceuticals Inc 31 - $32.58 $11,698,000 313,191 0.22% -383,000 48,191 1.68    Drug Manufacturers - ...
   (ZGNX)1 Year Chart         ZGNX Zogenix, Inc. 33 - $2.45 $9,463,000 2,751,000 0.18% 5,759,000 750,000 2.733    Drug Manufacturers - ...
   (TGTX)1 Year Chart         TGTX TG Therapeutics Inc 36 - $5.49 $8,579,000 2,199,656 0.16% 5,555,000 1,599,656 6.566    Drug Manufacturers - ...
   (DSCO)1 Year Chart         DSCO Discovery Laboratories Inc 38 - $2.01 $8,367,000 3,718,617 0.16% 5,391,000 2,200,000 6.787    Biotechnology
   (IRWD)1 Year Chart         IRWD Ironwood Pharmaceuticals Inc 43 - $9.71 $6,341,000 546,160 0.12% 881,000 85,000 0.505    Medical Laboratories ...
   (SGMO)1 Year Chart         SGMO Sangamo Biosciences Inc 46 - $14.16 $5,894,000 424,308 0.11% 4,040,000 247,601 0.809    Biotechnology

      11 Records Found
  1    
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