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  Name: BAKER BROS ADVISORS LLC
  City: NEW YORK
  State: NY
  Zip: 10021
   
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Portfolio Summary View Filing
  Filing Report Date : 2023-12-31
  Total Value : $8,651,176,000
  Total Value Change : $-8,563,281,000
  Securities Held Change : -17
   
All Securities Held : 82
  New Positions : 4
  Closed Positions : 21
  Increased Positions : 23
  Unchanged Positions : 42
  Decreased Positions : 13

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Holdings Found : 23     View All Holdings Currently Viewing:  Increased Positions     Page 1 of 1
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Ticker Company Name Position
Rank
New/Closed
Postion
Last
Close
    Value Shares Held
% of
Portfolio
Value
Change
Change In
Shares Held
   % of Company    Industry
   (INCY)1 Year Chart         INCY Incyte Corp 1 - $52.82 $2,271,687,000 36,179,122 26.26% 181,651,000 556 16.52    Biotechnology
   (MDGL)1 Year Chart         MDGL Madrigal Pharmaceuticals Inc 4 - $222.26 $455,772,000 1,969,798 5.27% 230,124,000 424,685 11.881    Diagnostic Substances
   (MRTX)1 Year Chart         MRTX Mirati Therapeutics, Inc. 6 - $58.70 $242,135,000 4,121,440 2.8% 180,725,000 2,711,656 6.157    Biotechnology
   (KYMR)1 Year Chart         KYMR Kymera Therapeutics, Inc. 8 - $0.00 $152,656,000 5,995,928 1.76% 86,625,000 1,245,528 9.987    N/A
   (RVMD)1 Year Chart         RVMD Revolution Medicines, Inc. 9 - $35.83 $147,663,000 5,148,657 1.71% 73,162,000 2,457,164 4.495    N/A
   (ABCL)1 Year Chart         ABCL Abcellera Biologics Inc. 10 - $0.00 $130,815,000 22,909,753 1.51% 35,304,000 2,146,430 8.511    N/A
   (REPL)1 Year Chart         REPL Replimune Group Inc 12 - $6.97 $80,467,000 9,545,336 0.93% 2,133,000 4,967,056 16.85    N/A
   (RARE)1 Year Chart         RARE Ultragenyx Pharmaceutical Inc 14 - $43.38 $70,130,000 1,466,547 0.81% 21,413,000 100,000 2.152    Restaurants
   (IMTX)1 Year Chart         IMTX Immatics N.V 16 - $10.26 $61,483,000 5,838,853 0.71% -3,838,000 198,037 9.281    N/A
   (DNLI)1 Year Chart         DNLI Denali Therapeutics Inc. 19 - $16.60 $55,950,000 2,607,196 0.65% 8,666,000 315,193 2.174    N/A
   (XENE)1 Year Chart         XENE Xenon Pharmaceuticals Inc. 23 - $0.00 $45,769,000 993,679 0.53% 20,093,000 242,040 1.589    N/A
   (CERS)1 Year Chart         CERS Cerus Corp 25 - $1.64 $42,071,000 19,477,339 0.49% 14,143,000 2,237,838 11.653    Biotechnology
   (EWTX)1 Year Chart         EWTX Edgewise Therapeutics, Inc. 29 - $0.00 $34,054,000 3,112,786 0.39% 28,039,000 2,063,087 4.459    N/A
   (SERA)1 Year Chart         SERA Sera Prognostics, Inc. 30 - $9.79 $32,498,000 5,434,399 0.38% 29,679,000 3,919,057 18.554    N/A
   (BCYC)1 Year Chart         BCYC Bicycle Therapeutics Ltd 31 - $0.00 $32,370,000 1,790,390 0.37% 15,418,000 946,576 6.087    N/A
   (IGMS)1 Year Chart         IGMS Igm Biosciences, Inc. 32 - $0.00 $30,672,000 3,691,011 0.35% 4,305,000 533,247 15.24    N/A
   (VERV)1 Year Chart         VERV Verve Therapeutics, Inc. 35 - $0.00 $23,580,000 1,691,530 0.27% 4,797,000 275,000 2.545    N/A
   (GRCL)1 Year Chart         GRCL Gracell Biotechnologies Adr... 37 - $0.00 $20,883,000 2,080,000 0.24% 18,003,000 1,080,000 3.095    N/A
   (STOK)1 Year Chart         STOK Stoke Therapeutics, Inc. 44 - $0.00 $10,679,000 2,030,134 0.12% 4,824,000 544,219 4.266    N/A
   (SGMT)1 Year Chart         SGMT Sagimet Biosciences Inc. 52 - $3.97 $7,894,000 1,456,518 0.09% 719,000 641,159 6.819    N/A
   (TSHA)1 Year Chart         TSHA Taysha Gene Therapies, Inc. 57 - $0.00 $7,088,000 4,004,756 0.08% -827,000 1,500,000 10.827    N/A
   (HOOK)1 Year Chart         HOOK Hookipa Pharma Inc. 58 - $0.00 $6,584,000 8,128,151 0.08% 1,616,000 62,753 15.975    N/A
   (XNCR)1 Year Chart         XNCR Xencor Inc 60 - $18.95 $5,211,000 245,431 0.06% 2,730,000 122,304 0.37    Biotechnology

      23 Records Found
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