| |
Institutional
Holders
Total
Institutions:
 |
206  46 |
|
|
Total
shares held :
|
64,436,039 |
|
|
% of shares
held :
|
93.67% |
|
| Changes In:
|
|
|
|
New/increased
positions vs
old/decreased
positions :
|
75 |
|
|
Amount
of shares held :
|
16,246,457 |
|
|
% of shares
held change :
|
23.62% |
|
| Quarter
Price vs. Current Price:
|
|
|
Quarter Price vs.
Current Price:
|
|
|
|
|
|
|
Last
Quarter's Starting
Price :
|
$18.84 |
|
|
Last
Quarter's Ending
Price :
|
$41.16 |
|
|
Last
Quarter's Average
Price :
|
$23.38 |
|
|
Change
from last quarter's
avg. price
to the last closing :
|
|
|
|
11.85 (50.68%) |
|
|
|
|
|
|
| All
Securities Held : |
Positions
|
Shares
|
%
Of
Total Shares
|
|
|
New
Positions : |
69
|
12,456,358
|
19.33%
|
|
|
|
Increased
Positions : |
71
|
9,927,798
|
15.41%
|
|
|
|
Unchanged
Positions : |
24
|
2,904,564
|
4.51%
|
|
|
|
Decreased
Positions : |
42
|
-4,756,677
|
-7.38%
|
|
|
|
Closed
Positions : |
23
|
-1,381,022
|
-2.14%
|
|
|
|
Guru
Positions : |
1
|
0
|
0%
|
|
|
|
Free Registration Required For Full Results
|
Institution Name |
Portfolio
Position |
New/Closed
Position |
Filing Date |
Total Shares |
Total Value |
Change in Shares |
File |
  EcoR1 Capital LLC |
3 |
- |
2024-03-31 |
6,726,491 |
$277,670,000 |
0 |
|
| VANGUARD GROUP INC |
1362 |
- |
2024-03-31 |
6,299,556 |
$260,046,000 |
1,448,166 |
|
| BLACKROCK INC. |
1557 |
- |
2024-03-31 |
5,494,254 |
$226,803,000 |
139,390 |
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
440 |
- |
2024-03-31 |
4,368,418 |
$180,329,000 |
536,295 |
|
| RTW INVESTMENTS LLC |
21 |
- |
2024-03-31 |
3,297,897 |
$136,137,000 |
-915,586 |
|
| Avidity Partners Management LP |
3 |
- |
2024-03-31 |
2,985,190 |
$123,229,000 |
73 |
|
| Paradigm Biocapital Advisors LP |
9 |
- |
2024-03-31 |
2,614,935 |
$107,945,000 |
1,683,632 |
|
| Bellevue Group AG |
20 |
- |
2024-03-31 |
2,390,800 |
$98,692,000 |
-116,931 |
|
| FMR LLC |
1061 |
- |
2024-03-31 |
2,388,954 |
$98,616,000 |
144,935 |
|
| CITADEL ADVISORS LLC |
257 |
- |
2024-03-31 |
2,280,613 |
$94,144,000 |
-159,368 |
|
| J P MORGAN CHASE & CO |
1027 |
- |
2024-03-31 |
1,699,843 |
$70,170,000 |
-472,986 |
|
| Nextech Invest AG |
5 |
- |
2024-03-31 |
1,408,394 |
$58,139,000 |
-287,251 |
|
| STATE STREET CORP |
1652 |
- |
2024-03-31 |
1,382,167 |
$57,056,000 |
195,693 |
|
| GEODE CAPITAL MANAGEMENT LLC |
1300 |
- |
2024-03-31 |
1,313,316 |
$54,223,000 |
190,689 |
|
| New Leaf Venture Partners L.L.C. |
1 |
- |
2024-03-31 |
1,289,521 |
$53,231,000 |
0 |
|
| COMMODORE CAPITAL LP |
10 |
- |
2024-03-31 |
1,275,000 |
$52,632,000 |
275,000 |
|
| PERCEPTIVE ADVISORS LLC |
37 |
- |
2024-03-31 |
1,236,603 |
$51,047,000 |
882,521 |
|
| ARROWPOINT ASSET MANAGEMENT, LLC |
52 |
- |
2024-03-31 |
1,205,568 |
$49,766,000 |
-364,327 |
|
| NORGES BANK |
1054 |
- |
2023-12-31 |
877,708 |
$36,126,000 |
175,953 |
|
| MORGAN STANLEY |
2322 |
- |
2024-03-31 |
675,509 |
$27,885,000 |
-17,970 |
|
| ADAGE CAPITAL PARTNERS GP LLC |
383 |
- |
2024-03-31 |
630,000 |
$26,006,000 |
-159,485 |
|
| VR Adviser LLC |
22 |
- |
2024-03-31 |
627,788 |
$25,915,000 |
0 |
|
| Boxer Capital LLC |
24 |
- |
2024-03-31 |
608,614 |
$25,124,000 |
0 |
|
| GOLDMAN SACHS GROUP INC/ |
1401 |
- |
2024-03-31 |
594,403 |
$24,537,000 |
264,944 |
|
| Finepoint Capital LP |
4 |
- |
2024-03-31 |
539,100 |
$22,254,000 |
34,400 |
|
| SCHWAB CHARLES INVESTMENT MANAGEMENT INC |
1558 |
- |
2024-03-31 |
528,055 |
$21,798,000 |
58,581 |
|
| NORTHERN TRUST CORP |
1559 |
- |
2024-03-31 |
509,127 |
$21,017,000 |
17,892 |
|
| Candriam Luxembourg S.C.A. |
171 |
- |
2024-03-31 |
462,554 |
$19,094,000 |
-25,001 |
|
| DIMENSIONAL FUND ADVISORS INC |
2046 |
- |
2024-03-31 |
434,300 |
$17,928,000 |
-57,577 |
|
| Woodline Partners LP |
190 |
- |
2024-03-31 |
422,204 |
$17,429,000 |
34,574 |
|
| RA CAPITAL MANAGEMENT LLC |
68 |
- |
2024-03-31 |
421,348 |
$17,393,000 |
0 |
|
| Aquilo Capital Management LLC |
4 |
- |
2024-03-31 |
405,766 |
$16,750,000 |
-83,387 |
|
| AIC LTD |
9 |
*New |
2024-03-31 |
5,000 |
$16,570,000 |
5,000 |
|
| VOLORIDGE INVESTMENT MANAGEMENT LLC |
386 |
- |
2024-03-31 |
379,376 |
$15,661,000 |
69,713 |
|
| RENAISSANCE TECHNOLOGIES LLC |
781 |
- |
2024-03-31 |
361,973 |
$14,942,000 |
124,400 |
|
| Opaleye Management Inc. |
7 |
- |
2024-03-31 |
330,000 |
$13,622,000 |
66,300 |
|
| AMERICAN CENTURY COMPANIES INC |
1079 |
- |
2024-03-31 |
325,518 |
$13,437,000 |
-69,849 |
|
| GILDER GAGNON HOWE & CO LLC |
106 |
- |
2024-03-31 |
324,844 |
$13,410,000 |
-8,680 |
|
| D E SHAW & CO INC |
717 |
- |
2024-03-31 |
303,638 |
$12,534,000 |
218,707 |
|
| NUVEEN ASSET MANAGEMENT, LLC |
1457 |
- |
2024-03-31 |
296,017 |
$12,220,000 |
-62,162 |
|
| UBS Group AG |
1483 |
- |
2024-03-31 |
294,044 |
$12,138,000 |
37,058 |
|
| Frazier Life Sciences Management L.P. |
40 |
- |
2024-03-31 |
285,331 |
$11,778,000 |
0 |
|
| Schonfeld Strategic Advisors LLC |
292 |
- |
2024-03-31 |
281,097 |
$11,604,000 |
35,229 |
|
| NORDEA INVESTMENT MANAGEMENT AB |
401 |
- |
2024-03-31 |
276,482 |
$11,557,000 |
-2,255 |
|
| BROWN ADVISORY HOLDINGS INC |
406 |
- |
2024-03-31 |
274,175 |
$11,318,000 |
8,744 |
|
| FRANKLIN RESOURCES INC |
984 |
- |
2024-03-31 |
268,153 |
$11,069,000 |
252,942 |
|
| CREDIT SUISSE/ |
878 |
- |
2024-03-31 |
262,224 |
$10,825,000 |
120,116 |
|
| MILLENNIUM MANAGEMENT LLC |
1403 |
- |
2024-03-31 |
243,667 |
$10,059,000 |
-115,146 |
|
| PICTET ASSET MANAGEMENT SA |
622 |
- |
2023-06-30 |
403,034 |
$10,003,000 |
-128,046 |
|
| WASATCH ADVISORS INC |
172 |
- |
2024-03-31 |
207,426 |
$8,563,000 |
-15,516 |
|
| TD ASSET MANAGEMENT INC |
658 |
- |
2024-03-31 |
199,348 |
$8,229,000 |
52,400 |
|
| UBS GLOBAL ASSET MANAGEMENT AMERICAS INC |
1041 |
- |
2024-03-31 |
194,496 |
$8,029,000 |
-38,121 |
|
| TANG CAPITAL MANAGEMENT LLC |
45 |
- |
2024-03-31 |
180,000 |
$7,430,000 |
100,000 |
|
| BANK OF NEW YORK MELLON CORP |
2132 |
- |
2024-03-31 |
177,261 |
$7,317,000 |
-10,042 |
|
| FEDERATED INVESTORS INC /PA/ |
641 |
- |
2024-03-31 |
171,963 |
$7,099,000 |
33,935 |
|
| Rhenman & Partners Asset Management AB |
49 |
- |
2024-03-31 |
170,000 |
$7,018,000 |
35,730 |
|
| PANAGORA ASSET MANAGEMENT INC |
292 |
- |
2024-03-31 |
163,090 |
$6,732,000 |
144,683 |
|
| AMUNDI |
891 |
- |
2024-03-31 |
193,341 |
$6,630,000 |
-2,379 |
|
| BANK OF AMERICA CORP /DE/ |
2802 |
- |
2024-03-31 |
154,486 |
$6,377,000 |
-550 |
|
| BNP PARIBAS ARBITRAGE SA |
890 |
- |
2024-03-31 |
147,255 |
$6,079,000 |
-49,797 |
|
| YALE UNIVERSITY |
4 |
- |
2024-03-31 |
143,522 |
$5,925,000 |
0 |
|
| FIRST TRUST ADVISORS LP |
1226 |
*New |
2024-03-31 |
139,313 |
$5,751,000 |
139,313 |
|
| DEUTSCHE BANK AG |
1201 |
- |
2024-03-31 |
134,955 |
$5,571,000 |
48,959 |
|
| Parkman Healthcare Partners LLC |
51 |
- |
2024-03-31 |
124,979 |
$5,159,000 |
-42,022 |
|
| MANUFACTURERES LIFE INSURANCE CO |
1191 |
- |
2024-03-31 |
119,481 |
$4,932,000 |
30,253 |
|
| Qube Research & Technologies Ltd |
1080 |
- |
2024-03-31 |
114,401 |
$4,722,000 |
104,203 |
|
| Swiss National Bank |
1334 |
- |
2024-03-31 |
114,100 |
$4,710,000 |
24,600 |
|
| JANE STREET GROUP LLC |
1362 |
- |
2024-03-31 |
109,678 |
$4,528,000 |
12,461 |
|
| TWO SIGMA INVESTMENTS LLC |
955 |
- |
2024-03-31 |
105,919 |
$4,372,000 |
105,919 |
|
| PUTNAM INVESTMENTS LLC |
413 |
- |
2023-12-31 |
103,118 |
$4,244,000 |
87,671 |
|
| Trexquant Investment LP |
365 |
- |
2024-03-31 |
102,373 |
$4,226,000 |
41,130 |
|
| BANQUE PICTET & CIE SA |
167 |
- |
2024-03-31 |
84,920 |
$3,505,000 |
-8,013 |
|
| Squarepoint Ops LLC |
843 |
- |
2024-03-31 |
81,871 |
$3,380,000 |
75,269 |
|
| L & S ADVISORS INC |
71 |
*New |
2024-03-31 |
80,202 |
$3,311,000 |
80,202 |
|
| CASTLEARK MANAGEMENT LLC |
156 |
- |
2024-03-31 |
76,990 |
$3,178,000 |
5,420 |
|
| WELLS FARGO & CO/MN |
2258 |
- |
2024-03-31 |
76,637 |
$3,164,000 |
17,474 |
|
| ZACKS INVESTMENT MANAGEMENT |
256 |
- |
2024-03-31 |
75,821 |
$3,130,000 |
4,126 |
|
| VERITION FUND MANAGEGMENT LLC |
607 |
- |
2024-03-31 |
75,551 |
$3,119,000 |
75,551 |
|
| TWINBEECH CAPITAL LP |
284 |
*New |
2024-03-31 |
74,443 |
$3,073,000 |
74,443 |
|
| AMERIPRISE FINANCIAL INC |
2579 |
- |
2024-03-31 |
74,393 |
$3,071,000 |
418 |
|
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
444 |
- |
2024-03-31 |
74,000 |
$3,055,000 |
0 |
|
| RHUMBLINE ADVISERS |
1702 |
- |
2024-03-31 |
71,205 |
$2,939,000 |
2,315 |
|
| KENNEDY CAPITAL MANAGEMENT INC |
454 |
*New |
2024-03-31 |
67,703 |
$2,795,000 |
67,703 |
|
| Hennion & Walsh Asset Management Inc. |
207 |
- |
2024-03-31 |
61,862 |
$2,554,000 |
25,778 |
|
| NOMURA ASSET MANAGEMENT CO LTD |
680 |
- |
2024-03-31 |
60,873 |
$2,513,000 |
0 |
|
| ING INVESTMENT MANAGEMENT LLC |
1142 |
- |
2024-03-31 |
58,519 |
$2,416,000 |
21,228 |
|
| LEGAL & GENERAL GROUP PLC |
1848 |
- |
2024-03-31 |
57,688 |
$2,381,000 |
10,962 |
|
| STATE OF NEW JERSEY COMMON PENSION FUND D |
1491 |
*New |
2024-03-31 |
57,145 |
$2,359,000 |
57,145 |
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
1312 |
- |
2024-03-31 |
57,059 |
$2,355,000 |
8,497 |
|
| ALLIANCEBERNSTEIN L.P. |
1825 |
- |
2024-03-31 |
56,470 |
$2,331,000 |
3,970 |
|
| NEUBERGER BERMAN GROUP LLC |
1071 |
- |
2024-03-31 |
56,370 |
$2,327,000 |
-384 |
|
| PDT PARTNERS, LLC |
166 |
- |
2024-03-31 |
56,134 |
$2,317,000 |
18,047 |
|
| BARCLAYS PLC |
1815 |
- |
2024-03-31 |
55,474 |
$2,291,000 |
-28,147 |
|
| STATE OF WISCONSIN INVESTMENT BOARD |
1211 |
- |
2024-03-31 |
53,711 |
$2,217,000 |
2,615 |
|
| Cubist Systematic Strategies LLC |
840 |
- |
2024-03-31 |
53,203 |
$2,196,000 |
53,203 |
|
| HIGHVISTA STRATEGIES LLC |
45 |
*New |
2024-03-31 |
51,122 |
$2,110,000 |
51,122 |
|
| Yelin Lapidot Holdings Management Ltd. |
45 |
- |
2024-03-31 |
49,503 |
$2,043,000 |
0 |
|
| Engineers Gate Manager LP |
473 |
- |
2024-03-31 |
49,324 |
$2,036,000 |
38,560 |
|
| SECTORAL ASSET MANAGEMENT INC |
39 |
- |
2024-03-31 |
48,780 |
$2,014,000 |
-17,220 |
|
| ALGERT COLDIRON INVESTORS LLC |
416 |
- |
2024-03-31 |
48,195 |
$1,989,000 |
-26,376 |
|
|
100 Records found
|
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