|  | 
               
               
                | Company 
                  Roster 
 
 
                     
                     
                      |  | Total 
                        Insiders  : | 42 |  |   
                      |  | Total 
                          Direct Shares : | 2,808,544 |   
                      |  | Total 
                          Indirect Shares : | 109,988,286 |   
                      |  | % 
                          Held by Insiders: | 3.53% |  | 
 |  
                |  |  
| Filer's Name | Relation | Direct Date | Direct Shares | Indirect Date | Indirect Shares |  |    Hahn Mark W |  | 2025-10-13 | 10,046 | 2025-10-13 | 0 |  |    Hirano Patricia C |  | 2025-07-01 | 13,206 |  | 0 |  |    Pauls Matthew |  | 2025-06-05 | 10,491 | 2024-06-06 | 0 |  |    Bir Dawn Carter |  | 2025-06-05 | 16,991 | 2024-08-15 | 0 |  |    Harris William G |  | 2025-06-05 | 19,392 | 2016-10-06 | 0 |  |    Volck Birgitte |  | 2025-06-05 | 17,536 | 2020-01-22 | 0 |  |    Sinclair Andrew |  | 2025-06-05 | 10,491 | 2022-03-29 | 18,022,602 |  |    Yen Kristen |  | 2025-03-27 | 28,143 |  | 0 |  |    Manning Meredith |  | 2025-03-27 | 45,351 | 2024-07-17 | 0 |  |    Mackaness James H |  | 2025-03-27 | 105,176 | 2020-01-23 | 0 |  |    Huang Michael F. |  | 2025-03-27 | 36,817 | 2024-07-17 | 0 |  |    Anish Bhatnagar |  | 2025-03-27 | 577,076 | 2015-08-12 | 0 |  |    Mario Ernest |  | 2024-06-06 | 193,066 | 2024-06-06 | 21,789 |  |    Vivo Opportunity Fund Holdings, L.p. | 10% Owner | 2023-10-02 | 0 | 2025-03-28 | 4,458,294 |  |    Abingworth Bioventures Vii Lp | 10% Owner | 2023-09-28 | 0 | 2023-09-28 | 1,531,436 |  |    Collinson Stuart J | Director | 2020-07-31 | 1,018 | 2018-02-05 | 7,251,728 |  |    Melincoff Gwen A | Director | 2019-11-19 | 10,000 | 2019-11-19 | 0 |  |    Abingworth Llp | 10% Owner | 2019-10-25 | 0 | 2022-03-29 | 18,022,602 |  |    Bioasia Investments Iv Llc | 10% Owner | 2019-05-17 | 0 | 2019-05-20 | 0 |  |    Schuler Jack W |  | 2018-12-21 | 0 | 2022-12-09 | 36,595 |  |    Feinberg Larry N | 10% Owner | 2018-12-19 | 0 | 2018-12-19 | 329,158 |  |    Oracle Partners Lp | 10% Owner | 2018-05-14 | 0 | 2020-06-08 | 3,670,384 |  |    Technology Partners Affiliates Vii Lp | 10% Owner | 2018-03-07 | 0 | 2018-09-13 | 36,823 |  |    Kirnon Stephen | Director | 2018-02-05 | 14,996 | 2017-04-07 | 0 |  |    Glasheen James Walter | Director, 10% Owner | 2018-02-05 | 1,419,489 | 2018-02-05 | 7,050,691 |  |    Dalal Rajen | Director | 2018-02-05 | 12,056 | 2017-01-23 | 0 |  |    Engelsen Steinar J | Director | 2018-02-05 | 41,831 |  | 0 |  |    Shah Mahendra | Director | 2018-02-05 | 27,153 | 2017-03-07 | 0 |  |    Vivo Ventures V, Llc | 10% Owner | 2017-10-02 | 45,059 | 2017-10-02 | 14,241,635 |  |    Forward Ventures V Lp | 10% Owner | 2017-03-07 | 0 | 2017-03-07 | 7,251,728 |  |    Vivo Ventures Fund V, L.p. | 10% Owner | 2017-03-07 | 0 | 2018-05-14 | 49,456 |  |    Otoole David D | See Remarks | 2016-08-18 | 44,750 | 2015-03-13 | 0 |  |    Vivo Ventures V Affiliates Fund, L.p. | 10% Owner | 2015-08-12 | 0 | 2019-12-02 | 3,633,805 |  |    Teknoinvest Viii Gp Ks | 10% Owner | 2014-11-12 | 108,410 | 2014-11-12 | 90,155 |  |    Wolter Jonathan |  |  | 0 |  | 0 |  |    Carlyle Genesis Uk Llc | 10% Owner |  | 0 | 2022-08-01 | 18,022,602 |  |    Nabhan Antoun |  |  | 0 |  | 0 |  |    Kung Frank | 10% Owner |  | 0 | 2014-11-12 | 31,758 |  |    Engleman Edgar | Director, 10% Owner |  | 0 | 2018-02-05 | 4,027,292 |  |    Phelps Gina |  |  | 0 |  | 0 |  |    Edelman Joseph | 10% Owner |  | 0 | 2023-06-06 | 2,207,753 |  |    Wondka Anthony |  |  | 0 |  | 0 |  |