|     | 
           
            
               
               
                   Company 
                  Roster  
                   
                  
                     
                     
                      |  
                        
                       | 
                      Total 
                        Insiders  : | 
                       
                        26                         | 
                         | 
                     
                     
                      |  
                        
                       | 
                       
                         Total 
                          Direct Shares : 
                       | 
                       
                         
                        5,987,749                          | 
                     
                     
                      |  
                        
                       | 
                       
                         Total 
                          Indirect Shares : 
                       | 
                        
                         
                        11,804,771                          | 
                     
                     
                      |   | 
                       
                         % 
                          Held by Insiders: 
                       | 
                       
                        15.14%                          | 
                     
                     
                    | 
                  
                     
                  
                  
                 | 
               
              
                |   | 
               
               
             
            
| Filer's Name | 
Relation | 
Direct Date   | 
Direct Shares | 
Indirect Date | 
Indirect Shares | 
 
     Plovanic William J. | 
 | 
2025-10-31 | 
11,925 | 
2025-10-31 | 
0 | 
 
     Rocchio Betty Jo | 
 | 
2025-10-09 | 
11,925 | 
2025-10-09 | 
0 | 
 
     Firestone Gregory A. | 
Chief Commercial Officer | 
2025-08-03 | 
106,790 | 
2023-08-03 | 
0 | 
 
     Blizard Jeffrey | 
President | 
2025-06-02 | 
119,125 | 
2024-06-04 | 
0 | 
 
     Colleran Lisa N | 
Director | 
2025-05-28 | 
18,470 | 
2022-06-01 | 
0 | 
 
     Obrien Federica F. | 
Director | 
2025-05-28 | 
18,470 | 
2022-06-01 | 
0 | 
 
     Azarbarzin Kurt | 
Director | 
2025-05-28 | 
18,470 | 
2019-11-13 | 
498,606 | 
 
     Evans Douglas G | 
Director | 
2025-05-28 | 
18,470 | 
2022-06-01 | 
0 | 
 
     Burgess Vincent J | 
Director | 
2025-05-28 | 
23,330 | 
2022-06-01 | 
0 | 
 
     Smeykal Megan | 
Chief Accounting Officer, Controller | 
2025-03-31 | 
36,831 | 
 | 
0 | 
 
     Talmo Paul | 
Chief Technology Officer | 
2025-03-31 | 
123,882 | 
 | 
0 | 
 
     Koblish Antony | 
Chief Executive Officer, Director | 
2025-03-31 | 
590,110 | 
 | 
0 | 
 
     Cuca Roberto | 
COO and CFO | 
2025-02-23 | 
208,233 | 
2021-12-02 | 
0 | 
 
     Murphy Peter C. | 
Chief Commercial Officer | 
2024-03-31 | 
48,129 | 
2021-02-24 | 
0 | 
 
     Nosenzo John | 
Director | 
2023-06-01 | 
6,270 | 
2022-06-01 | 
0 | 
 
     Opaleye Management Inc. | 
10% Owner | 
2022-06-10 | 
0 | 
2022-11-03 | 
124,813 | 
 
     Quaker Bioventures Capital Ii, L.p. | 
10% Owner | 
2022-06-02 | 
0 | 
 | 
0 | 
 
     Greenhalgh Ellis Skott | 
Chief Technology Officer | 
2022-02-24 | 
27,826 | 
2019-11-13 | 
0 | 
 
     Brennan Nora | 
Chief Financial Officer | 
2021-03-31 | 
17,696 | 
2019-11-13 | 
0 | 
 
     Persenaire Maarten | 
Chief Medical Officer | 
2021-02-24 | 
90,887 | 
 | 
0 | 
 
     Ew Healthcare Partners Fund 2-Ugp, L.p. | 
10% Owner | 
2020-12-31 | 
1,475,293 | 
2022-08-17 | 
4,105,709 | 
 
     Wong Roderick | 
10% Owner | 
2019-12-13 | 
0 | 
2019-12-17 | 
1,139,358 | 
 
     Orbimed Capital Gp Iv Llc | 
10% Owner | 
2019-11-13 | 
3,027,542 | 
2024-07-02 | 
2,407,242 | 
 
     Friedman Ashley | 
Director | 
2019-11-13 | 
0 | 
2019-11-13 | 
505,281 | 
 
     Pacira Biosciences, Inc. | 
Director, 10% Owner | 
2019-11-13 | 
0 | 
2019-11-13 | 
774,056 | 
 
     Zuga Matt | 
Director | 
2019-11-08 | 
0 | 
2019-11-13 | 
498,606 | 
 
     Oliva Adele C | 
Director, 10% Owner | 
 | 
0 | 
2019-11-13 | 
1,751,100 | 
 
 
            
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