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| Name: |
SPHERA FUNDS MANAGEMENT LTD. |
| City: |
Tel Aviv |
| State: |
L3 |
| Zip: |
64739 |
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 |
Ticker |
Company Name |
Position
Rank |
New/Closed
Postion |
Last
Close |
Value |
Shares Held |
% of
Portfolio |
Value
Change |
Change In
Shares Held |
% of Company |
Industry |
|
TEVA |
Teva Pharmaceutical Industr... |
1 |
- |
$16.76 |
$24,164,000 |
1,572,181 |
5.96% |
-10,421,000 |
3,000 |
0.143 |
Drug Manufacturers - ... |
|
|
SNDX |
Syndax Pharmaceuticals Inc |
2 |
- |
$9.04 |
$20,442,000 |
1,663,974 |
5.04% |
2,182,000 |
282,733 |
1.77 |
N/A |
|
|
SNY |
Sanofi Aventis (ADR) |
3 |
- |
$47.85 |
$16,888,000 |
304,515 |
4.16% |
-1,657,000 |
-80,000 |
0.012 |
Drug Manufacturers - ... |
|
|
NVMI |
Nova Measuring Instruments,... |
4 |
- |
$267.64 |
$16,718,000 |
90,697 |
4.12% |
3,297,000 |
22,551 |
0.321 |
Semiconductor Equipme... |
|
|
AZN |
AstraZeneca Plc (ADR) |
5 |
- |
$69.85 |
$12,867,000 |
175,060 |
3.17% |
-1,879,000 |
-50,000 |
0.007 |
Drug Manufacturers - ... |
|
|
BBIO |
Bridgebio Pharma, Inc. |
6 |
- |
$44.86 |
$12,674,000 |
366,608 |
3.13% |
-12,167,000 |
-538,671 |
0.211 |
N/A |
|
|
SRPT |
Sarepta Therapeutics Inc |
7 |
- |
$17.11 |
$10,079,000 |
157,931 |
2.49% |
-1,949,000 |
59,010 |
0.166 |
Drug Manufacturers - ... |
|
|
RARE |
Ultragenyx Pharmaceutical Inc |
8 |
- |
$36.52 |
$9,682,000 |
267,385 |
2.39% |
57,000 |
38,609 |
0.29 |
Restaurants |
|
|
LLY |
Eli Lilly & Co |
9 |
- |
$775.45 |
$9,655,000 |
11,690 |
2.38% |
-528,000 |
-1,500 |
0.001 |
Drug Manufacturers - ... |
|
|
CLDX |
Celldex Therapeutics Inc |
10 |
- |
$20.29 |
$9,217,000 |
507,829 |
2.27% |
-2,764,000 |
33,726 |
0.688 |
Diagnostic Substances |
|
|
JNJ |
Johnson & Johnson |
11 |
- |
$152.41 |
$8,761,000 |
52,831 |
2.16% |
-1,338,000 |
-17,000 |
0.002 |
Drug Manufacturers - ... |
|
|
NVO |
Novo Nordisk A/S (ADR) |
12 |
- |
$68.51 |
$8,199,000 |
118,080 |
2.02% |
-238,000 |
20,000 |
0.007 |
Drug Manufacturers - ... |
|
|
ELDN |
Eledon Pharmaceuticals Ord Shs |
13 |
- |
$2.69 |
$7,821,000 |
2,307,119 |
1.93% |
-2,692,000 |
-244,500 |
5.817 |
N/A |
|
|
MLYS |
Mineralys Therapeutics, Inc. |
14 |
- |
$0.00 |
$7,393,000 |
465,526 |
1.82% |
5,046,000 |
274,854 |
0.936 |
N/A |
|
|
AMZN |
Amazon.com Inc |
15 |
- |
$223.30 |
$6,965,000 |
36,607 |
1.72% |
-6,770,000 |
-26,000 |
0 |
Internet Software & S... |
|
|
ABBV |
Abbvie Inc. |
16 |
- |
$182.31 |
$6,339,000 |
30,256 |
1.56% |
252,000 |
-4,000 |
0.002 |
Drug Manufacturers - ... |
|
|
PHVS |
Pharvaris N V Ord Shs |
17 |
- |
$0.00 |
$6,027,000 |
383,856 |
1.49% |
-1,414,000 |
-4,327 |
0.093 |
N/A |
|
|
ORA |
Ormat Technologies Inc |
18 |
- |
$84.15 |
$5,945,000 |
84,000 |
1.47% |
595,000 |
5,000 |
0.15 |
Electric Utilities |
|
|
CYTK |
Cytokinetics Inc |
19 |
- |
$33.16 |
$5,826,000 |
144,961 |
1.44% |
-1,372,000 |
-8,060 |
0.106 |
Biotechnology |
|
|
META |
Meta Platforms Inc |
20 |
- |
$733.63 |
$5,742,000 |
9,962 |
1.42% |
-6,554,000 |
-11,039 |
0 |
Internet Service Prov... |
|
|
NVS |
Novartis AG (ADR) |
21 |
- |
$120.01 |
$5,574,000 |
50,000 |
1.37% |
708,000 |
0 |
0.002 |
Drug Manufacturers - ... |
|
|
MRK |
Merck & Co Inc |
22 |
- |
$79.10 |
$5,350,000 |
59,600 |
1.32% |
-579,000 |
0 |
0.002 |
Drug Manufacturers - ... |
|
|
PRAX |
Praxis Precision Medicines,... |
23 |
- |
$0.00 |
$5,327,000 |
140,660 |
1.31% |
-1,721,000 |
49,077 |
0.268 |
N/A |
|
|
NICE |
NICE Systems Ltd (ADR) |
24 |
- |
$165.09 |
$5,134,000 |
33,303 |
1.27% |
-2,084,000 |
-9,197 |
0.053 |
Computer Peripherals |
|
|
GSK |
GlaxoSmithKline Plc (ADR) |
25 |
- |
$40.41 |
$5,036,000 |
130,000 |
1.24% |
639,000 |
0 |
0.006 |
Drug Manufacturers - ... |
|
|
SEDG |
Solaredge Technologies Inc |
26 |
- |
$19.80 |
$5,003,000 |
309,216 |
1.23% |
-97,000 |
-65,784 |
0.543 |
N/A |
|
|
ETNB |
89bio, Inc. |
27 |
- |
$9.86 |
$4,495,000 |
618,343 |
1.11% |
143,000 |
61,811 |
0.584 |
N/A |
|
|
MRUS |
Merus Nv |
28 |
- |
$52.99 |
$4,484,000 |
106,532 |
1.11% |
-1,005,000 |
-24,000 |
0.149 |
N/A |
|
|
IMTX |
Immatics N.V |
29 |
- |
$5.43 |
$4,154,000 |
921,111 |
1.02% |
-2,395,000 |
0 |
0.893 |
N/A |
|
|
APLS |
Apellis Pharmaceuticals Inc |
30 |
- |
$17.43 |
$3,966,000 |
181,346 |
0.98% |
-2,615,000 |
-24,905 |
0.146 |
N/A |
|
|
MAZE |
Maze Therapeutics, Inc. |
31 |
New |
$12.13 |
$3,915,000 |
355,554 |
0.97% |
3,915,000 |
355,554 |
0.812 |
N/A |
|
|
TVTX |
Travere Therapeutics, Inc |
32 |
- |
$14.77 |
$3,584,000 |
200,000 |
0.88% |
-261,000 |
-20,700 |
0.223 |
N/A |
|
|
SVRA |
Savara Inc |
33 |
- |
$2.21 |
$3,557,000 |
1,284,151 |
0.88% |
-162,000 |
72,618 |
0.78 |
Biotechnology |
|
|
ARWR |
Arrowhead Pharmaceuticals Inc |
34 |
- |
$16.08 |
$3,536,000 |
277,550 |
0.87% |
-178,000 |
80,000 |
0.271 |
Business Services |
|
|
DYN |
Dyne Therapeutics, Inc. |
35 |
- |
$9.57 |
$3,444,000 |
329,262 |
0.85% |
-2,122,000 |
93,000 |
0.285 |
N/A |
|
|
ANNX |
Annexon, Inc. |
36 |
- |
$0.00 |
$3,405,000 |
1,764,387 |
0.84% |
-2,972,000 |
521,348 |
1.534 |
N/A |
|
|
JANX |
Janux Therapeutics, Inc. |
37 |
- |
$0.00 |
$3,398,000 |
125,840 |
0.84% |
-261,000 |
57,507 |
0.241 |
N/A |
|
|
CYBN |
Cybin Inc |
38 |
- |
$8.15 |
$3,343,000 |
527,222 |
0.82% |
-1,403,000 |
-10,889 |
0.059 |
N/A |
|
|
IMVT |
Immunovant Inc |
39 |
New |
$0.00 |
$3,326,000 |
194,638 |
0.82% |
3,326,000 |
194,638 |
0.224 |
N/A |
|
|
NVDA |
NVIDIA Corporation |
40 |
- |
$157.75 |
$3,209,000 |
29,605 |
0.79% |
3,209,000 |
29,605 |
0 |
Semiconductor - Speci... |
|
|
RZLT |
Rezolute, Inc |
41 |
- |
$4.35 |
$3,136,000 |
1,081,447 |
0.77% |
-2,577,000 |
-84,448 |
1.953 |
N/A |
|
|
RNA |
Avidity Biosciences, Inc. |
42 |
New |
$29.03 |
$3,129,000 |
106,000 |
0.77% |
3,129,000 |
106,000 |
0.079 |
N/A |
|
|
AMGN |
Amgen Inc |
43 |
New |
$277.13 |
$3,116,000 |
10,000 |
0.77% |
3,116,000 |
10,000 |
0.002 |
Biotechnology |
|
|
BIIB |
Biogen Idec Inc |
44 |
- |
$126.08 |
$3,111,000 |
22,738 |
0.77% |
-366,000 |
0 |
0.015 |
Biotechnology |
|
|
ACOG |
Alpha Cognition Inc. |
45 |
- |
$9.11 |
$3,021,000 |
596,992 |
0.75% |
-631,000 |
-23,008 |
3.844 |
N/A |
|
|
VIGL |
Vigil Neuroscience, Inc. |
46 |
- |
$0.00 |
$2,856,000 |
1,604,429 |
0.7% |
302,000 |
102,000 |
5.675 |
N/A |
|
|
NTLA |
Intellia Therapeutics, Inc. |
47 |
- |
$9.56 |
$2,709,000 |
381,080 |
0.67% |
-2,725,000 |
-85,000 |
0.375 |
N/A |
|
|
DAWN |
Day One Biopharmaceuticals,... |
48 |
- |
$0.00 |
$2,656,000 |
334,987 |
0.66% |
-1,588,000 |
0 |
0.335 |
N/A |
|
|
AMAT |
Applied Materials Inc |
49 |
New |
$183.21 |
$2,612,000 |
18,000 |
0.64% |
2,612,000 |
18,000 |
0.002 |
Semiconductor Equipme... |
|
|
SRRK |
Scholar Rock Holding Corp |
50 |
- |
$35.81 |
$2,514,000 |
78,193 |
0.62% |
-1,384,000 |
-12,000 |
0.09 |
N/A |
|
|
CRM |
Salesforce.com Inc |
51 |
New |
$273.42 |
$2,442,000 |
9,100 |
0.6% |
2,442,000 |
9,100 |
0.001 |
Internet Software & S... |
|
|
BHVN |
Biohaven Ltd. |
52 |
- |
$14.09 |
$2,399,000 |
99,784 |
0.59% |
-3,446,000 |
-56,710 |
0.106 |
N/A |
|
|
ENGN |
Engene Holdings Inc. |
53 |
- |
$3.66 |
$2,367,000 |
528,365 |
0.58% |
-1,357,000 |
-31,635 |
1.196 |
N/A |
|
|
SKYE |
Skye Bioscience Inc |
54 |
- |
$4.11 |
$2,347,000 |
1,476,353 |
0.58% |
-2,081,000 |
-88,275 |
5.26 |
N/A |
|
|
WDAY |
Workday, Inc. |
55 |
- |
$237.37 |
$2,335,000 |
10,000 |
0.58% |
-245,000 |
0 |
0.005 |
Application Software |
|
|
SWTX |
Springworks Therapeutics, Inc. |
56 |
- |
$0.00 |
$2,295,000 |
52,009 |
0.57% |
-1,318,000 |
-47,991 |
0.062 |
N/A |
|
|
PFE |
Pfizer Inc |
57 |
- |
$24.19 |
$2,281,000 |
90,000 |
0.56% |
-107,000 |
0 |
0.002 |
Drug Manufacturers - ... |
|
|
KURA |
Kura Oncology Inc |
58 |
- |
$5.67 |
$2,267,000 |
343,522 |
0.56% |
-3,047,000 |
-266,565 |
0.41 |
N/A |
|
|
ELVN |
Enliven Therapeutics Ord Shs |
59 |
New |
$0.00 |
$2,199,000 |
111,743 |
0.54% |
2,199,000 |
111,743 |
0.222 |
N/A |
|
|
TSEM |
Tower Semiconductor Ltd (USA) |
60 |
- |
$43.43 |
$2,195,000 |
61,549 |
0.54% |
-6,363,000 |
-104,600 |
0.057 |
Semiconductor - Integ... |
|
|
UBER |
Uber Technologies, Inc |
61 |
- |
$91.53 |
$2,186,000 |
30,000 |
0.54% |
376,000 |
0 |
0.002 |
N/A |
|
|
GOOG |
Alphabet Inc |
62 |
- |
$178.27 |
$2,109,000 |
13,500 |
0.52% |
-6,175,000 |
-30,000 |
0 |
Search Engines & Info... |
|
|
VKTX |
Viking Therapeutics, Inc. |
63 |
- |
$26.52 |
$2,011,000 |
83,270 |
0.5% |
-2,145,000 |
-20,000 |
0.083 |
N/A |
|
|
COGT |
Cogent Biosciences, Inc. |
64 |
New |
$7.10 |
$2,007,000 |
335,024 |
0.49% |
2,007,000 |
335,024 |
0.257 |
N/A |
|
|
VTGN |
Vistagen Therapeutics Inc |
65 |
- |
$1.97 |
$1,976,000 |
790,550 |
0.49% |
-409,000 |
-18,000 |
2.925 |
Biotechnology |
|
|
AVGO |
Broadcom Limited |
66 |
- |
$269.35 |
$1,958,000 |
11,695 |
0.48% |
-1,955,000 |
-5,185 |
0 |
Semiconductor- Broad... |
|
|
IONS |
Ionis Pharmaceuticals Inc |
67 |
- |
$39.80 |
$1,925,000 |
63,821 |
0.47% |
-306,000 |
0 |
0.04 |
Drug Manufacturers - ... |
|
|
NKE |
Nike Inc B |
68 |
New |
$72.04 |
$1,908,000 |
30,050 |
0.47% |
1,908,000 |
30,050 |
0.002 |
Textile - Apparel Foo... |
|
|
CHKP |
Check Point Software Techno... |
69 |
- |
$216.45 |
$1,899,000 |
8,334 |
0.47% |
-4,754,000 |
-27,301 |
0.006 |
Security Software & S... |
|
|
RCKT |
Rocket Pharmaceuticals |
70 |
- |
$2.53 |
$1,813,000 |
271,792 |
0.45% |
-1,603,000 |
0 |
0.293 |
N/A |
|
|
MSFT |
Microsoft Corp |
71 |
- |
$495.94 |
$1,724,000 |
4,592 |
0.43% |
-7,687,000 |
-17,735 |
0 |
Application Software |
|
|
NTR |
Nutrien Ltd |
72 |
- |
$58.12 |
$1,535,000 |
30,894 |
0.38% |
-966,000 |
-25,000 |
0.005 |
N/A |
|
|
GPCR |
Structure Therapeutics Inc. |
73 |
New |
$21.08 |
$1,454,000 |
84,000 |
0.36% |
1,454,000 |
84,000 |
0.133 |
N/A |
|
|
WIX |
WIX.COM Ltd |
74 |
- |
$158.01 |
$1,438,000 |
8,800 |
0.35% |
-6,984,000 |
-30,453 |
0.016 |
N/A |
|
|
FROG |
Jfrog Ltd |
75 |
- |
$43.91 |
$1,372,000 |
42,871 |
0.34% |
-4,227,000 |
-147,510 |
0.048 |
N/A |
|
|
CAMT |
Camtek Ltd |
76 |
- |
$84.46 |
$1,354,000 |
23,086 |
0.33% |
-1,577,000 |
-13,201 |
0.059 |
Scientific & Technica... |
|
|
PMN |
Promis Neurosciences Ord Shs |
77 |
- |
$0.48 |
$1,342,000 |
1,929,297 |
0.33% |
-487,000 |
0 |
22.486 |
N/A |
|
|
ORIC |
Oric Pharmaceuticals, Inc. |
78 |
- |
$0.00 |
$1,310,000 |
234,834 |
0.32% |
-895,000 |
-38,379 |
0.333 |
N/A |
|
|
CEVA |
CEVA Inc |
79 |
New |
$22.56 |
$1,253,000 |
48,920 |
0.31% |
1,253,000 |
48,920 |
0.22 |
Semiconductor - Speci... |
|
|
BMY |
Bristol-Myers Squibb Co |
80 |
- |
$46.35 |
$1,220,000 |
20,000 |
0.3% |
89,000 |
0 |
0.001 |
Drug Manufacturers - ... |
|
|
VTYX |
Ventyx Biosciences, Inc. |
81 |
- |
$2.34 |
$1,165,000 |
1,012,749 |
0.29% |
-1,053,000 |
0 |
1.433 |
N/A |
|
|
NNDM |
Nano Dimension Ltd |
82 |
New |
$1.64 |
$1,141,000 |
717,518 |
0.28% |
1,141,000 |
717,518 |
0.744 |
N/A |
|
|
INZY |
Inozyme Pharma, Inc. |
83 |
- |
$0.00 |
$1,084,000 |
1,191,140 |
0.27% |
-2,215,000 |
0 |
1.929 |
N/A |
|
|
OTLK |
Outlook Therapeutics Inc |
84 |
- |
$1.60 |
$1,046,000 |
857,142 |
0.26% |
1,046,000 |
857,142 |
0.697 |
N/A |
|
|
ATXS |
Astria Therapeutics, Inc |
85 |
- |
$5.57 |
$1,014,000 |
189,800 |
0.25% |
-236,000 |
50,000 |
0.32 |
N/A |
|
|
CMMB |
Chemomab Therapeutics Ameri... |
86 |
- |
$0.00 |
$981,000 |
900,428 |
0.24% |
-1,217,000 |
-314,147 |
13.203 |
N/A |
|
|
CATX |
Perspective Therapeutics Inc |
87 |
- |
$3.76 |
$980,000 |
460,247 |
0.24% |
-488,000 |
0 |
0.687 |
Medical Instruments &... |
|
|
MRVL |
Marvell Technology, Inc. |
88 |
- |
$77.16 |
$928,000 |
15,070 |
0.23% |
-7,755,000 |
-63,541 |
0.002 |
N/A |
|
|
ARVN |
Arvinas Holding Company, Llc |
89 |
New |
$7.54 |
$878,000 |
125,000 |
0.22% |
878,000 |
125,000 |
0.14 |
N/A |
|
|
XENE |
Xenon Pharmaceuticals Inc. |
90 |
- |
$0.00 |
$876,000 |
26,097 |
0.22% |
-1,166,000 |
-26,000 |
0.035 |
N/A |
|
|
PERI |
Perion Network Ltd |
91 |
- |
$11.29 |
$835,000 |
102,612 |
0.21% |
-34,000 |
0 |
0.218 |
Search Engines & Info... |
|
|
RGLS |
Regulus Therapeutics Inc. |
92 |
New |
$8.16 |
$792,000 |
452,845 |
0.2% |
792,000 |
452,845 |
0.31 |
Biotechnology |
|
|
LRMR |
Larimar Therapeutics Inc |
93 |
- |
$1.15 |
$788,000 |
366,304 |
0.19% |
-975,000 |
-89,300 |
0.548 |
N/A |
|
|
CRVS |
Corvus Pharmaceuticals, Inc. |
94 |
- |
$3.89 |
$655,000 |
205,859 |
0.16% |
-2,023,000 |
-294,632 |
0.322 |
N/A |
|
|
HOWL |
Werewolf Therapeutics, Inc. |
95 |
- |
$0.00 |
$609,000 |
626,810 |
0.15% |
-319,000 |
0 |
1.542 |
N/A |
|
|
VIR |
Vir Biotechnology, Inc. |
96 |
- |
$0.00 |
$589,000 |
90,855 |
0.15% |
-3,682,000 |
-490,974 |
0.071 |
N/A |
|
|
APRE |
Aprea Therapeutics, Inc. |
97 |
- |
$0.00 |
$551,000 |
270,000 |
0.14% |
-337,000 |
0 |
1.286 |
N/A |
|
|
ZURA |
Zura Bio Ltd |
98 |
- |
$1.05 |
$543,000 |
421,229 |
0.13% |
-1,184,000 |
-269,489 |
0.666 |
N/A |
|
|
KZR |
Kezar Life Sciences, Inc. |
99 |
- |
$4.44 |
$529,000 |
108,473 |
0.13% |
-200,000 |
0 |
0.159 |
N/A |
|
|
JSPR |
Jasper Therapeutics Ord Shs |
100 |
- |
$15.12 |
$525,000 |
122,017 |
0.13% |
-2,377,000 |
-13,703 |
0.12 |
N/A |
|
