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  Name: SPHERA FUNDS MANAGEMENT LTD.
  City: Tel Aviv
  State: L3
  Zip: 64739
   
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Portfolio Summary View Filing
  Filing Report Date : 2023-12-31
  Total Value : $538,636,000
  Total Value Change : $121,945,000
  Securities Held Change : 14
   
All Securities Held : 89
  New Positions : 21
  Closed Positions : 9
  Increased Positions : 20
  Unchanged Positions : 18
  Decreased Positions : 30

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Holdings Found : 18     View All Holdings Currently Viewing:  Unchanged Positions     Page 1 of 1
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Ticker Company Name Position
Rank
New/Closed
Postion
Last
Close
    Value Shares Held
% of
Portfolio
Value
Change
Change In
Shares Held
   % of Company    Industry
   (SNY)1 Year Chart         SNY Sanofi Aventis (ADR) 2 - $49.46 $24,841,000 499,515 4.61% -1,953,000 0 0.02    Drug Manufacturers - ...
   (MRK)1 Year Chart         MRK Merck & Co Inc 8 - $131.20 $13,475,000 123,600 2.5% 750,000 0 0.005    Drug Manufacturers - ...
   (KURA)1 Year Chart         KURA Kura Oncology Inc 17 - $20.59 $10,113,000 703,287 1.88% 3,699,000 0 0.923    N/A
   (NVO)1 Year Chart         NVO Novo Nordisk A/S (ADR) 18 - $124.02 $9,629,000 93,080 1.79% 1,164,000 0 0.005    Drug Manufacturers - ...
   (LLY)1 Year Chart         LLY Eli Lilly & Co 24 - $755.91 $8,272,000 14,190 1.54% 650,000 0 0.001    Drug Manufacturers - ...
   (ABBV)1 Year Chart         ABBV Abbvie Inc. 29 - $160.81 $7,129,000 46,000 1.32% 272,000 0 0.003    Drug Manufacturers - ...
   (NVS)1 Year Chart         NVS Novartis AG (ADR) 39 - $97.34 $6,058,000 60,000 1.12% -54,000 0 0.002    Drug Manufacturers - ...
   (GSK)1 Year Chart         GSK GlaxoSmithKline Plc (ADR) 55 - $40.41 $3,706,000 100,000 0.69% 81,000 0 0.005    Drug Manufacturers - ...
   (PFE)1 Year Chart         PFE Pfizer Inc 59 - $27.70 $2,591,000 90,000 0.48% -394,000 0 0.002    Drug Manufacturers - ...
   (HOWL)1 Year Chart         HOWL Werewolf Therapeutics, Inc. 60 - $0.00 $2,419,000 626,810 0.45% 1,078,000 0 2.274    N/A
   (PMN)1 Year Chart         PMN Promis Neurosciences Ord Shs 61 - $1.99 $2,109,000 1,834,042 0.39% -1,577,000 0 21.376    N/A
   (KZR)1 Year Chart         KZR Kezar Life Sciences, Inc. 64 - $0.85 $1,944,000 2,051,676 0.36% -497,000 0 3.001    N/A
   (RIGL)1 Year Chart         RIGL Rigel Pharmaceuticals Inc 66 - $1.22 $1,781,000 1,228,126 0.33% 455,000 0 0.727    Drug Manufacturers - ...
   (RZLT)1 Year Chart         RZLT Rezolute, Inc 75 - $2.97 $989,000 996,710 0.18% -327,000 0 2.968    N/A
   (APGE)1 Year Chart         APGE Apogee Therapeutics, Inc. 76 - $52.20 $838,000 30,000 0.16% 199,000 0 0.081    N/A
   (SELB)1 Year Chart         SELB Selecta Biosciences Inc 78 - $0.50 $519,000 752,137 0.1% -278,000 0 0.696    N/A
   (ELEV)1 Year Chart         ELEV Elevation Oncology, Inc. 80 - $3.82 $483,000 900,000 0.09% -113,000 0 3.944    N/A
   (IMTXW)1 Year Chart         IMTXW Immatics N.V - Warrants 83 - $0.00 $292,000 100,000 0.05% -62,000 0 1.111    N/A

      18 Records Found
  1    
Page 1 of 1
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