Siren L.L.C. : Portfolio Holdings

Portfolio Summary	View Filing
Filing Report Date :	2025-03-31
Total Value :	$1,772,778,000
Total Value Change :	$-490,530,000
Securities Held Change :	-1

All Securities Held :	116
New Positions :	22
Closed Positions :	24
Increased Positions :	29
Unchanged Positions :	24
Decreased Positions :	41

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Holdings Found : 100		View All Holdings	Currently Viewing: ALL				Page 1 of 1

Menu	Ticker	Company Name	Position Rank	New/Closed Postion	Last Close	Value	Shares Held	% of Portfolio	Value Change	Change In Shares Held	% of Company	Industry
	SRRK	Scholar Rock Holding Corp	1	-	$35.81	$297,388,000	9,250,005	16.78%	-102,397,000	0	10.685	N/A
	BGNE	Beigene Ltd	2	-	$241.20	$135,728,000	498,689	7.66%	14,979,000	-155,032	0.55	N/A
	KYMR	Kymera Therapeutics, Inc.	3	-	$0.00	$88,687,000	3,240,313	5%	-30,785,000	270,580	4.585	N/A
	BPMC	Blueprint Medicines Corp	4	New	$128.11	$64,273,000	726,167	3.63%	64,273,000	726,167	1.1	N/A
	CRNX	Crinetics Pharmaceuticals, ...	5	-	$29.96	$56,636,000	1,688,611	3.19%	-25,666,000	78,959	1.835	N/A
	APLS	Apellis Pharmaceuticals Inc	6	-	$17.43	$56,390,000	2,578,396	3.18%	-33,477,000	-237,862	2.079	N/A
	IRON	Disc Medicine, Inc	7	New	$54.50	$53,207,000	1,071,865	3%	53,207,000	1,071,865	3.605	N/A
	SLNO	Soleno Therapeutics Inc	8	-	$0.16	$51,968,000	727,337	2.93%	36,154,000	375,519	0.914	N/A
	ASND	Ascendis Pharma AS	9	-	$172.22	$44,789,000	287,366	2.53%	3,857,000	-9,955	0.445	N/A
	MRUS	Merus Nv	10	-	$52.99	$43,920,000	1,043,467	2.48%	10,935,000	259,055	1.457	N/A
	BCAX	Bicara Therapeutics Inc.	11	-	$8.71	$42,570,000	3,267,083	2.4%	-14,443,000	-5,744	6.007	N/A
	CNTA	Centessa Pharmaceuticals Plc	12	-	$0.00	$42,565,000	2,960,029	2.4%	-7,763,000	-44,648	2.26	N/A
	NAMS	Newamsterdam Pharma Ord Shs	13	-	$0.00	$39,139,000	1,912,030	2.21%	-14,719,000	-183,608	2.344	N/A
	EWTX	Edgewise Therapeutics, Inc.	14	-	$13.17	$37,322,000	1,696,444	2.11%	17,715,000	962,101	1.645	N/A
	ARWR	Arrowhead Pharmaceuticals Inc	15	-	$16.08	$34,014,000	2,669,880	1.92%	-20,538,000	-231,801	2.61	Business Services
	RNA	Avidity Biosciences, Inc.	16	-	$29.03	$32,785,000	1,110,610	1.85%	3,000	-16,685	0.823	N/A
	WVE	Wave Life Sciences Ltd.	17	-	$6.67	$29,866,000	3,696,322	1.68%	-16,528,000	-54,169	3.103	N/A
	TBLA	Taboolacom Ord Shs	18	-	$0.00	$29,410,000	9,969,495	1.66%	-6,979,000	0	4.727	N/A
	DYN	Dyne Therapeutics, Inc.	19	-	$9.57	$28,430,000	2,717,987	1.6%	-3,316,000	1,370,531	2.355	N/A
	SLDB	Solid Biosciences Inc	20	-	$4.72	$27,439,000	7,415,905	1.55%	12,443,000	3,666,864	19.212	N/A
	XENE	Xenon Pharmaceuticals Inc.	21	-	$0.00	$24,584,000	732,761	1.39%	-4,572,000	-11,008	0.973	N/A
	APGE	Apogee Therapeutics, Inc.	22	-	$43.38	$22,229,000	594,994	1.25%	-11,625,000	-152,331	1.017	N/A
	RVMD	Revolution Medicines, Inc.	23	-	$36.91	$19,934,000	563,755	1.12%	-5,066,000	-7,793	0.332	N/A
	TRVI	Trevi Therapeutics, Inc.	24	-	$0.00	$18,013,000	2,863,793	1.02%	6,040,000	-42,267	2.815	N/A
	VERA	Vera Therapeutics, Inc.	25	-	$0.00	$17,948,000	747,216	1.01%	-14,127,000	-11,249	1.363	N/A
	LXRX	Lexicon Pharmaceuticals Inc	26	-	$0.82	$17,934,000	38,918,903	1.01%	-10,866,000	0	10.766	Diagnostic Substances
	PRTA	Prothena Corp Plc	27	-	$6.08	$15,884,000	1,283,555	0.9%	651,000	183,715	2.39	N/A
	BCYC	Bicycle Therapeutics Ltd	28	-	$0.00	$15,390,000	1,812,752	0.87%	-10,362,000	-26,646	2.628	N/A
	STOK	Stoke Therapeutics, Inc.	29	-	$11.63	$14,945,000	2,247,347	0.84%	-7,115,000	247,347	3.587	N/A
	RYTM	Rhythm Pharmaceuticals, Inc.	30	New	$62.73	$14,701,000	277,533	0.83%	14,701,000	277,533	0.391	N/A
	SMMT	Summit Therapeutics Inc	31	New	$20.60	$13,407,000	695,000	0.76%	13,407,000	695,000	0.099	N/A
	SEPN	Septerna, Inc.	32	-	$10.51	$12,753,000	2,202,514	0.72%	-37,685,000	0	4.96	N/A
	RCUS	Arcus Biosciences Inc	33	-	$7.95	$12,655,000	1,612,077	0.71%	-11,349,000	0	2.483	N/A
	IHS	Ihs Holding Ord Shs	34	-	$5.56	$12,306,000	2,357,520	0.69%	5,422,000	0	0.719	N/A
	ERAS	Erasca, Inc.	35	-	$1.31	$11,997,000	8,757,249	0.68%	-10,235,000	-99,930	3.101	N/A
	DNLI	Denali Therapeutics Inc.	36	-	$14.10	$11,168,000	821,513	0.63%	-5,829,000	-12,515	0.574	N/A
	PCVX	Vaxcyte, Inc.	37	-	$0.00	$11,160,000	295,543	0.63%	-13,397,000	-4,448	0.217	N/A
	AMZN	Amazon.com Inc	38	-	$223.30	$10,750,000	56,500	0.61%	2,742,000	20,000	0.001	Internet Software & S...
	MSFT	Microsoft Corp	39	-	$495.94	$10,699,000	28,500	0.6%	1,004,000	5,500	0	Application Software
	RELY	Remitly Global, Inc.	40	-	$18.91	$10,201,000	490,449	0.58%	-868,000	0	0.304	N/A
	TSHA	Taysha Gene Therapies, Inc.	41	-	$0.00	$9,055,000	6,514,737	0.51%	-2,367,000	-87,738	3.485	N/A
	CGEM	Cullinan Oncology Ord Shs	42	-	$0.00	$9,034,000	1,193,410	0.51%	-5,720,000	-17,947	0.274	N/A
	CRWD	Crowdstrike Holdings, Inc.	43	-	$499.33	$8,815,000	25,000	0.5%	603,000	1,000	0.014	N/A
	SLN	Silence Therapeutics Adr Re...	44	-	$0.00	$7,867,000	2,789,833	0.44%	-11,616,000	-41,937	9.359	N/A
	GOOGL	Alphabet Inc	45	-	$178.53	$7,841,000	50,703	0.44%	6,516,000	43,703	0.001	Search Engines & Info...
	RNAC	Cartesian Therapeutics, Inc	46	-	$10.68	$7,424,000	563,272	0.42%	-2,825,000	-8,964	3.165	N/A
	ADBE	Adobe Systems Inc	47	-	$385.83	$7,401,000	19,298	0.42%	3,489,000	10,500	0.004	Application Software
	KRRO	Korro Bio	48	-	$0.00	$7,292,000	418,833	0.41%	-8,653,000	0	1.245	N/A
	NOW	Servicenow, Inc.	49	-	$1,022.42	$7,266,000	9,126	0.41%	1,324,000	3,521	0.005	Information Technolog...
	SEER	Seer, Inc.	50	-	$0.00	$6,760,000	4,000,000	0.38%	-2,480,000	0	7.266	N/A
	PDD	Bloom Energy Corp	51	-	$105.14	$6,261,000	52,901	0.35%	1,130,000	0	0.008	N/A
	AGLE	Aeglea Biotherapeutics, Inc.	52	-	$0.60	$5,947,000	368,598	0.34%	-2,760,000	-5,402	0.603	N/A
	GOSS	Gossamer Bio Inc	53	-	$1.25	$5,730,000	5,208,968	0.32%	1,018,000	0	2.311	N/A
	ORIC	Oric Pharmaceuticals, Inc.	54	-	$0.00	$5,622,000	1,007,575	0.32%	-2,509,000	0	1.428	N/A
	UPB	Upstream Bio, Inc.	55	-	$10.93	$4,825,000	788,450	0.27%	-8,327,000	-11,550	1.488	N/A
	NVDA	NVIDIA Corporation	56	-	$157.75	$4,816,000	44,432	0.27%	-1,755,000	-4,500	0	Semiconductor - Speci...
	TSM	Taiwan Semiconductor Mfg. C...	57	-	$228.57	$4,731,000	28,500	0.27%	1,769,000	13,500	0.001	Semiconductor - Integ...
	DDOG	Datadog, Inc.	58	-	$0.00	$4,705,000	47,425	0.27%	358,000	17,000	0.018	N/A
	NMRA	Neumora Therapeutics, Inc.	59	-	$0.76	$4,358,000	4,358,283	0.25%	-42,241,000	-37,817	2.854	N/A
	FROG	Jfrog Ltd	60	-	$43.91	$4,212,000	131,616	0.24%	679,000	11,500	0.148	N/A
	DT	Dynatrace, Inc.	61	-	$0.00	$4,136,000	87,729	0.23%	-360,000	5,000	0.028	N/A
	MTSR	Metsera, Inc.	62	New	$28.59	$4,083,000	150,000	0.23%	4,083,000	150,000	0.143	N/A
	RCKT	Rocket Pharmaceuticals	63	-	$2.53	$3,944,000	591,263	0.22%	-3,598,000	-8,737	0.638	N/A
	CRM	Salesforce.com Inc	64	New	$273.42	$3,918,000	14,600	0.22%	3,918,000	14,600	0.002	Internet Software & S...
	EDU	New Oriental Education & Te...	65	-	$54.14	$3,801,000	79,500	0.21%	-595,000	11,000	0.047	Education & Training ...
	RAPP	Rapport Therapeutics, Inc.	66	-	$11.43	$3,796,000	378,469	0.21%	-3,020,000	-5,728	1.035	N/A
	IONQ	Ionq Ord Shs	67	-	$10.40	$3,752,000	170,000	0.21%	-3,349,000	0	0.088	N/A
	IGMS	Igm Biosciences, Inc.	68	-	$0.00	$3,744,000	3,255,826	0.21%	-16,605,000	-74,596	13.443	N/A
	AADI	Aadi Bioscience, Inc	69	New	$1.93	$3,706,000	2,082,000	0.21%	3,706,000	2,082,000	9.966	N/A
	TIL	Instil Bio Ord Shs	70	-	$0.00	$3,540,000	203,933	0.2%	-134,000	11,500	0.159	N/A
	TNGX	Tango Therapeutics Ord Shs	71	-	$0.00	$3,515,000	2,565,342	0.2%	-4,531,000	-38,555	2.515	N/A
	VIGL	Vigil Neuroscience, Inc.	72	-	$0.00	$3,501,000	1,967,064	0.2%	116,000	-23,974	6.958	N/A
	SION	Sionna Therapeutics, Inc.	73	New	$0.00	$3,400,000	325,000	0.19%	3,400,000	325,000	0.737	N/A
	YNDX	Yandex Nv	74	-	$51.84	$2,955,000	140,000	0.17%	-369,000	20,000	0.044	Internet Software & S...
	FHTX	Foghorn Therapeutics Inc.	75	-	$0.00	$2,631,000	720,720	0.15%	-771,000	0	1.303	N/A
	RDDT	Reddit, Inc.	76	New	$143.01	$2,465,000	23,500	0.14%	2,465,000	23,500	0.02	N/A
	LPLA	LPL Investment Holdings Inc	77	New	$364.96	$2,454,000	7,500	0.14%	2,454,000	7,500	0.009	Investment Brokerage ...
	SGMT	Sagimet Biosciences Inc.	78	-	$7.87	$2,363,000	724,771	0.13%	-898,000	0	3.393	N/A
	ELDN	Eledon Pharmaceuticals Ord Shs	79	New	$2.69	$2,340,000	690,170	0.13%	2,340,000	690,170	1.74	N/A
	TSLA	Tesla Motors Inc	80	New	$177.81	$2,332,000	9,000	0.13%	2,332,000	9,000	0	Auto Manufacturers
	KLRS	Kalaris Therapeutics, Inc	81	-	$2.62	$2,269,000	282,586	0.13%	-502,000	-6,314,581	0.458	N/A
	MRVL	Marvell Technology, Inc.	82	-	$77.16	$2,266,000	36,808	0.13%	1,714,000	31,808	0.004	N/A
	QCOM	QUALCOMM Inc	83	-	$158.54	$2,151,000	14,000	0.12%	-153,000	-1,000	0.001	Communication Equipment
	BEKE	KE Holdings Inc	84	-	$18.54	$2,109,000	105,000	0.12%	1,004,000	45,000	0.013	N/A
	LXEO	Lexeo Therapeutics, Inc.	85	-	$0.00	$2,094,000	603,435	0.12%	-1,877,000	0	0	N/A
	PRQR	ProQR Therapeutics N.V.	86	-	$2.04	$2,064,000	1,552,183	0.12%	-2,110,000	-22,817	3.096	N/A
	PANW	Palo Alto Networks Inc	87	-	$200.57	$1,962,000	11,500	0.11%	870,000	5,500	0.004	Networking & Communic...
	SAIL	Sailpoint, Inc.	88	New	$22.77	$1,781,000	95,000	0.1%	1,781,000	95,000	0.017	N/A
	BDTX	Black Diamond Therapeutics,...	89	-	$2.35	$1,622,000	1,046,517	0.09%	-618,000	0	2.027	N/A
	SARO	Standardaero, Inc.	90	New	$31.63	$1,515,000	56,855	0.09%	1,515,000	56,855	0.017	N/A
	BIOA	Bioage Labs, Inc.	91	-	$4.20	$1,438,000	382,406	0.08%	-809,000	-5,594	1.068	N/A
	TRML	Tourmaline Bio	92	-	$0.00	$1,391,000	91,426	0.08%	-463,000	0	0.221	N/A
	WK	Workiva Llc	93	-	$65.82	$1,328,000	17,500	0.07%	233,000	7,500	0.035	N/A
	BILL	Bill.com Holdings, Inc.	94	New	$45.57	$1,308,000	28,500	0.07%	1,308,000	28,500	0.027	N/A
	PYPL	Paypal Holdings, Inc.	95	-	$73.64	$1,305,000	20,000	0.07%	25,000	5,000	0.002	N/A
	GBIO	Generation Bio Co.	96	-	$0.00	$1,202,000	2,968,925	0.07%	-1,960,000	-13,808	4.997	N/A
	SEMR	Semrush Holdings, Inc.	97	-	$0.00	$1,166,000	125,000	0.07%	750,000	90,000	0.104	N/A
	PEGA	Pegasystems Inc	98	New	$53.32	$1,147,000	16,500	0.06%	1,147,000	16,500	0.02	Business Software & S...
	MDB	Mongodb Inc	99	New	$209.92	$965,000	5,500	0.05%	965,000	5,500	0.008	N/A
	NKE	Nike Inc B	100	New	$72.04	$952,000	15,000	0.05%	952,000	15,000	0.001	Textile - Apparel Foo...

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