Opaleye Management Inc. : Portfolio Holdings

Portfolio Summary	View Filing
Filing Report Date :	2025-03-31
Total Value :	$438,278,000
Total Value Change :	$-122,386,000
Securities Held Change :	6

All Securities Held :	43
New Positions :	15
Closed Positions :	9
Increased Positions :	8
Unchanged Positions :	6
Decreased Positions :	14

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Holdings Found : 51		View All Holdings	Currently Viewing: ALL				Page 1 of 1

Menu	Ticker	Company Name	Position Rank	New/Closed Postion	Last Close	Value	Shares Held	% of Portfolio	Value Change	Change In Shares Held	% of Company	Industry
	HROW	Harrow Health Inc	1	-	$30.88	$105,203,000	3,955,000	24%	-28,662,000	-35,000	15.359	Biotechnology
	ETON	Eton Pharmaceuticals, Inc.	2	-	$0.00	$37,020,000	2,852,070	8.45%	-970,000	0	16.196	N/A
	LQDA	Liquidia Technologies Inc	4	-	$13.10	$33,335,000	2,260,000	7.61%	13,365,000	561,858	2.943	N/A
	RYTM	Rhythm Pharmaceuticals, Inc.	5	-	$62.73	$25,955,000	490,000	5.92%	-2,035,000	-10,000	0.691	N/A
	CDXS	Codexis Inc	6	-	$2.39	$25,555,000	9,500,000	5.83%	-16,612,000	660,000	14.642	Biotechnology
	IMNM	Immunome Inc.	7	-	$8.77	$23,892,000	3,550,000	5.45%	2,227,000	1,510,000	6.377	N/A
	TGTX	TG Therapeutics Inc	8	-	$36.72	$21,095,000	535,000	4.81%	-46,931,000	-1,725,000	0.415	Drug Manufacturers - ...
	ARVN	Arvinas Holding Company, Llc	9	-	$7.54	$13,865,000	1,975,000	3.16%	-19,778,000	350,000	2.209	N/A
	OCUL	Ocular Therapeutix, Inc	10	-	$0.00	$11,691,000	1,595,000	2.67%	-25,394,000	-2,747,500	1.023	N/A
	EWTX	Edgewise Therapeutics, Inc.	11	-	$13.17	$8,690,000	395,000	1.98%	-4,126,000	-85,000	0.383	N/A
	TARA	Protara Therapeutics, Inc	12	-	$2.88	$7,370,000	1,730,000	1.68%	-2,266,000	-95,000	16.461	N/A
	DNA	Ginkgo Bioworks Holdings, Inc	13	-	$9.46	$6,812,000	1,195,000	1.55%	-4,972,000	-5,000	0.069	N/A
	ANIK	Anika Therapeutics Inc	14	New	$10.74	$5,937,000	395,000	1.35%	5,937,000	395,000	2.735	Biotechnology
	PTGX	Protagonist Therapeutics, Inc	15	-	$55.69	$5,078,000	105,000	1.16%	1,025,000	0	0.164	N/A
	XOMA	XOMA Corporation	16	-	$27.49	$5,043,000	253,043	1.15%	-1,527,000	3,043	2.245	Biotechnology
	TRVI	Trevi Therapeutics, Inc.	17	-	$0.00	$5,001,000	795,000	1.14%	-4,547,000	-1,522,500	0.781	N/A
	PVLA	Palvella Therapeutics Inc	18	New	$22.08	$4,824,000	172,357	1.1%	4,824,000	172,357	13.057	N/A
	GOSS	Gossamer Bio Inc	19	-	$1.25	$4,716,000	4,287,415	1.08%	654,000	-202,585	1.902	N/A
	ANAB	Anaptysbio Inc	20	New	$22.47	$4,665,000	250,933	1.06%	4,665,000	250,933	0.717	N/A
	IRON	Disc Medicine, Inc	21	New	$54.50	$4,219,000	85,000	0.96%	4,219,000	85,000	0.286	N/A
	LRMR	Larimar Therapeutics Inc	22	New	$1.15	$4,115,000	1,914,077	0.94%	4,115,000	1,914,077	2.865	N/A
	CGON	CG Oncology, Inc	23	New	$25.95	$4,016,000	163,988	0.92%	4,016,000	163,988	0.248	N/A
	SLRN	Acelyrin, Inc.	24	-	$2.27	$3,989,000	1,615,000	0.91%	-3,186,000	-620,000	1.662	N/A
	RCEL	Avita Therapeutics Inc	25	New	$6.09	$3,582,000	440,000	0.82%	3,582,000	440,000	2.035	N/A
	EPIX	ESSA Pharma Inc	26	-	$0.00	$3,492,000	2,209,998	0.8%	-464,000	0	5.025	Diagnostic Substances
	ZNTL	Zentalis Pharmaceuticals, Llc	27	-	$1.18	$3,156,000	1,985,000	0.72%	-2,200,000	217,500	2.284	N/A
	CRGX	Cargo Therapeutics, Inc.	28	-	$0.00	$2,713,000	666,503	0.62%	-8,102,000	-83,497	0	N/A
	ZYME	Zymeworks Inc	29	New	$12.47	$2,084,000	175,000	0.48%	2,084,000	175,000	0.25	N/A
	BDSX	Biodesix Inc	30	-	$0.00	$2,016,000	3,225,000	0.46%	-3,285,000	-240,000	2.221	N/A
	STOK	Stoke Therapeutics, Inc.	31	-	$11.63	$1,995,000	300,000	0.46%	1,719,000	275,000	0.479	N/A
	MBX	Mbx Biosciences, Inc.	32	New	$0.00	$1,845,000	250,000	0.42%	1,845,000	250,000	0.748	N/A
	OPTN	OptiNose Inc	33	New	$9.60	$1,770,000	193,039	0.4%	1,770,000	193,039	1.919	N/A
	OCUP	Ocuphire Pharma, Inc	34	New	$0.98	$1,546,000	1,175,000	0.35%	1,546,000	1,175,000	10.8	Biotechnology
	IBIO	Ibio Ord Shs	35	-	$0.20	$1,508,000	375,000	0.34%	589,000	0	0.417	Drug Manufacturers - ...
	KNSA	Kiniksa Pharmaceuticals, Ltd.	36	New	$28.04	$1,388,000	62,501	0.32%	1,388,000	62,501	0.155	N/A
	NRIX	Nurix Therapeutics, Inc.	37	-	$0.00	$1,366,000	115,000	0.31%	-5,765,000	-263,500	0.162	N/A
	RZLT	Rezolute, Inc	38	-	$4.35	$1,349,000	465,000	0.31%	-930,000	0	0.84	N/A
	SGMO	Sangamo Biosciences Inc	39	New	$0.52	$692,000	1,055,000	0.16%	692,000	1,055,000	0.748	Biotechnology
	PEPG	Pepgen Inc.	40	-	$1.15	$590,000	420,000	0.13%	173,000	310,000	1.289	N/A
	DERM	Journey Medical Ord Shs	41	New	$0.00	$409,000	69,323	0.09%	409,000	69,323	0.65	N/A
	VTYX	Ventyx Biosciences, Inc.	42	-	$2.34	$219,000	190,000	0.05%	-394,000	-90,000	0.269	N/A
	ADGM	Adagio Medical Holdings, Inc.	43	-	$1.27	$92,000	110,571	0.02%	-24,000	0	0.826	N/A
	NUVL	Nuvalent, Inc.	52	Closed	$0.00	$0	0	0%	-4,579,000	-58,500	0	N/A
	IMTX	Immatics N.V	45	Closed	$5.43	$0	0	0%	-1,173,000	-165,000	0	N/A
	ABCL	Abcellera Biologics Inc.	51	Closed	$0.00	$0	0	0%	-2,827,000	-965,000	0	N/A
	JSPR	Jasper Therapeutics Ord Shs	44	Closed	$15.12	$0	0	0%	-8,552,000	-400,000	0	N/A
	RGNX	Regenxbio Inc.	50	Closed	$8.39	$0	0	0%	-618,000	-80,000	0	N/A
	URGN	Urogen Pharma Ltd.	49	Closed	$13.49	$0	0	0%	-2,343,000	-220,000	0	N/A
	PCVX	Vaxcyte, Inc.	48	Closed	$0.00	$0	0	0%	-6,140,000	-75,000	0	N/A
	NAMS	Newamsterdam Pharma Ord Shs	47	Closed	$0.00	$0	0	0%	-8,353,000	-325,000	0	N/A
	LXEO	Lexeo Therapeutics, Inc.	46	Closed	$0.00	$0	0	0%	-855,000	-130,000	0	N/A

51 Records Found

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