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  Name: Opaleye Management Inc.
  City: Cambridge
  State: MA
  Zip: 02140
   
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Portfolio Summary View Filing
  Filing Report Date : 2023-12-31
  Total Value : $373,152,000
  Total Value Change : $65,773,000
  Securities Held Change : 5
   
All Securities Held : 45
  New Positions : 10
  Closed Positions : 7
  Increased Positions : 14
  Unchanged Positions : 7
  Decreased Positions : 14

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Holdings Found : 14     View All Holdings Currently Viewing:  Increased Positions     Page 1 of 1
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 Ticker Company Name Position
Rank		 New/Closed
Postion
Last
Close
     Value Shares Held
% of
Portfolio
Value
Change
Change In
Shares Held
    % of Company    Industry
   (HROW)1 Year Chart         HROW Harrow Health Inc 1 - $10.38 $42,784,000 3,820,000 11.47% -11,750,000 25,000 14.835    Biotechnology
   (TGTX)1 Year Chart         TGTX TG Therapeutics Inc 2 - $16.19 $37,832,000 2,215,000 10.14% 22,032,000 325,000 1.718    Drug Manufacturers - ...
   (CPRX)1 Year Chart         CPRX Catalyst Pharmaceutical Par... 6 - $14.72 $21,436,000 1,257,200 5.74% 7,350,000 52,200 1.213    Drugs - Generic
   (ETON)1 Year Chart         ETON Eton Pharmaceuticals, Inc. 9 - $0.00 $11,081,000 2,529,887 2.97% 947,000 99,617 14.366    N/A
   (CDXS)1 Year Chart         CDXS Codexis Inc 12 - $3.92 $9,289,000 3,045,525 2.49% 7,174,000 1,926,625 4.694    Biotechnology
   (IOVA)1 Year Chart         IOVA Iovance Biotherapeutics Inc 15 - $13.63 $7,293,000 897,000 1.95% 4,517,000 287,000 0.419    N/A
   (APLT)1 Year Chart         APLT Applied Therapeutics Inc. 24 - $0.00 $3,660,000 1,092,500 0.98% 1,436,000 199,500 2.276    N/A
   (RLMD)1 Year Chart         RLMD Relmada Therapeutics, Inc. 25 - $3.68 $3,631,000 877,000 0.97% 3,541,000 847,000 3.163    N/A
   (BDSX)1 Year Chart         BDSX Biodesix Inc 26 - $0.00 $3,611,000 496,500 0.97% 573,000 40,927 1.871    N/A
   (TRVI)1 Year Chart         TRVI Trevi Therapeutics, Inc. 27 - $0.00 $3,397,000 2,535,000 0.91% -322,000 829,100 4.231    N/A
   (NTLA)1 Year Chart         NTLA Intellia Therapeutics, Inc. 29 - $23.60 $3,019,000 99,000 0.81% 3,019,000 99,000 0.111    N/A
   (PGEN)1 Year Chart         PGEN Precigen Inc 40 - $1.42 $1,357,000 1,012,500 0.36% 39,000 84,000 0.567    Biotechnology
   (STRO)1 Year Chart         STRO Sutro Biopharma Inc 41 - $3.83 $1,293,000 301,491 0.35% 1,293,000 301,491 0.536    N/A
   (FULC)1 Year Chart         FULC Fulcrum Therapeutics, Inc. 43 - $0.00 $878,000 130,000 0.24% 878,000 130,000 0.206    N/A
      14 Records Found
  1    
Page 1 of 1
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