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  Name: Opaleye Management Inc.
  City: Cambridge
  State: MA
  Zip: 02140
   
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Portfolio Summary View Filing
  Filing Report Date : 2023-12-31
  Total Value : $373,152,000
  Total Value Change : $65,773,000
  Securities Held Change : 5
   
All Securities Held : 45
  New Positions : 10
  Closed Positions : 7
  Increased Positions : 14
  Unchanged Positions : 7
  Decreased Positions : 14

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Holdings Found : 14     View All Holdings Currently Viewing:  Decreased Positions     Page 1 of 1
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 Ticker Company Name Position
Rank		 New/Closed
Postion
Last
Close
     Value Shares Held
% of
Portfolio
Value
Change
Change In
Shares Held
    % of Company    Industry
   (RYTM)1 Year Chart         RYTM Rhythm Pharmaceuticals, Inc. 4 - $43.76 $28,042,000 610,000 7.51% 13,072,000 -43,000 0.994    N/A
   (OCUL)1 Year Chart         OCUL Ocular Therapeutix, Inc 5 - $0.00 $27,072,000 6,070,000 7.25% 6,762,000 -398,000 8.503    N/A
   (KROS)1 Year Chart         KROS Keros Therapeutics, Inc. 7 - $0.00 $14,214,000 357,500 3.81% 2,724,000 -2,900 1.052    N/A
   (CRNX)1 Year Chart         CRNX Crinetics Pharmaceuticals, ... 10 - $47.20 $10,941,000 307,500 2.93% -63,000 -62,500 0.53    N/A
   (BHVN)1 Year Chart         BHVN Biohaven Ltd. 13 - $40.69 $8,560,000 200,000 2.29% -2,858,000 -239,000 0.293    N/A
   (EWTX)1 Year Chart         EWTX Edgewise Therapeutics, Inc. 14 - $0.00 $7,647,000 699,000 2.05% 2,631,000 -176,405 1.001    N/A
   (MRNS)1 Year Chart         MRNS Marinus Pharmaceuticals Inc 18 - $1.51 $6,125,000 563,500 1.64% 1,424,000 -20,500 1.136    N/A
   (LQDA)1 Year Chart         LQDA Liquidia Technologies Inc 20 - $12.79 $5,353,000 445,000 1.43% 1,735,000 -125,700 1.179    N/A
   (XOMA)1 Year Chart         XOMA XOMA Corporation 23 - $24.78 $4,625,000 250,000 1.24% 757,000 -24,500 2.218    Biotechnology
   (LRMR)1 Year Chart         LRMR Larimar Therapeutics Inc 31 - $1.15 $2,837,000 623,500 0.76% -515,000 -225,000 1.561    N/A
   (GOSS)1 Year Chart         GOSS Gossamer Bio Inc 34 - $0.74 $2,721,000 2,982,200 0.73% -1,238,000 -1,772,000 3.156    N/A
   (KALV)1 Year Chart         KALV Kalvista Pharmaceuticals Inc 36 - $12.13 $1,838,000 150,000 0.49% -2,977,000 -350,000 0.444    N/A
   (NYXH)1 Year Chart         NYXH Nyxoah Ord Shs 38 - $0.00 $1,600,000 344,800 0.43% -1,515,000 -97,096 1.35    N/A
   (MOR)1 Year Chart         MOR Morphosys Ag 39 - $17.89 $1,436,000 145,000 0.38% -6,691,000 -1,064,380 0.111    N/A
      14 Records Found
  1    
Page 1 of 1
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