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  Name: Opaleye Management Inc.
  City: Cambridge
  State: MA
  Zip: 02140
   
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Portfolio Summary View Filing
  Filing Report Date : 2024-03-31
  Total Value : $455,647,000
  Total Value Change : $82,495,000
  Securities Held Change : 6
   
All Securities Held : 51
  New Positions : 13
  Closed Positions : 7
  Increased Positions : 16
  Unchanged Positions : 6
  Decreased Positions : 16

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Holdings Found : 16     View All Holdings Currently Viewing:  Decreased Positions     Page 1 of 1
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 Ticker Company Name Position
Rank		 New/Closed
Postion
Last
Close
     Value Shares Held
% of
Portfolio
Value
Change
Change In
Shares Held
    % of Company    Industry
   (RYTM)1 Year Chart         RYTM Rhythm Pharmaceuticals, Inc. 5 - $42.77 $22,315,000 515,000 4.9% -5,727,000 -95,000 0.726    N/A
   (CPRX)1 Year Chart         CPRX Catalyst Pharmaceutical Par... 6 - $15.06 $16,009,000 1,004,355 3.51% -5,427,000 -252,845 0.969    Drugs - Generic
   (JSPR)1 Year Chart         JSPR Jasper Therapeutics Ord Shs 9 - $15.12 $12,788,000 435,573 2.81% 9,644,000 -3,549,767 0.429    N/A
   (EWTX)1 Year Chart         EWTX Edgewise Therapeutics, Inc. 10 - $0.00 $12,130,000 665,000 2.66% 4,483,000 -34,000 0.721    N/A
   (SLRN)1 Year Chart         SLRN Acelyrin, Inc. 15 - $4.18 $10,665,000 1,580,000 2.34% -20,265,000 -2,566,138 1.626    N/A
   (CRNX)1 Year Chart         CRNX Crinetics Pharmaceuticals, ... 16 - $45.33 $9,830,000 210,000 2.16% -1,111,000 -97,500 0.286    N/A
   (ETON)1 Year Chart         ETON Eton Pharmaceuticals, Inc. 17 - $0.00 $9,172,000 2,445,781 2.01% -1,909,000 -84,106 13.889    N/A
   (LQDA)1 Year Chart         LQDA Liquidia Technologies Inc 25 - $12.94 $5,826,000 395,000 1.28% 473,000 -50,000 1.046    N/A
   (PCVX)1 Year Chart         PCVX Vaxcyte, Inc. 26 - $0.00 $5,806,000 85,000 1.27% 154,000 -5,000 0.079    N/A
   (NYXH)1 Year Chart         NYXH Nyxoah Ord Shs 27 - $0.00 $4,317,000 320,000 0.95% 2,717,000 -24,800 1.252    N/A
   (URGN)1 Year Chart         URGN Urogen Pharma Ltd. 30 - $19.20 $4,050,000 270,000 0.89% -750,000 -50,000 1.222    N/A
   (RLMD)1 Year Chart         RLMD Relmada Therapeutics, Inc. 33 - $3.01 $3,529,000 759,000 0.77% -102,000 -118,000 2.737    N/A
   (GOSS)1 Year Chart         GOSS Gossamer Bio Inc 37 - $0.52 $2,879,000 2,440,109 0.63% 158,000 -542,091 1.083    N/A
   (PGEN)1 Year Chart         PGEN Precigen Inc 42 - $1.63 $1,374,000 947,500 0.3% 17,000 -65,000 0.531    Biotechnology
   (LRMR)1 Year Chart         LRMR Larimar Therapeutics Inc 43 - $1.15 $1,324,000 174,413 0.29% -1,513,000 -449,087 0.437    N/A
   (MOR)1 Year Chart         MOR Morphosys Ag 45 - $18.14 $1,179,000 65,000 0.26% -257,000 -80,000 0.05    N/A
      16 Records Found
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