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  Name: BAKER BROS ADVISORS LLC
  City: NEW YORK
  State: NY
  Zip: 10021
   
Achive data
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Portfolio Summary View Filing
  Filing Report Date : 2024-03-31
  Total Value : $7,971,704,000
  Total Value Change : $-679,472,000
  Securities Held Change : 5
   
All Securities Held : 87
  New Positions : 12
  Closed Positions : 7
  Increased Positions : 15
  Unchanged Positions : 53
  Decreased Positions : 7

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Holdings Found : 53     View All Holdings Currently Viewing:  Unchanged Positions     Page 1 of 1
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 Ticker Company Name Position
Rank		 New/Closed
Postion
Last
Close
     Value Shares Held
% of
Portfolio
Value
Change
Change In
Shares Held
    % of Company    Industry
   (BGNE)1 Year Chart         BGNE Beigene Ltd 2 - $167.92 $1,652,870,000 10,568,897 20.73% -253,336,000 0 11.662    N/A
   (ACAD)1 Year Chart         ACAD Acadia Pharmaceuticals Inc 3 - $15.82 $792,567,000 42,864,612 9.94% -549,524,000 0 26.664    Biotechnology
   (MDGL)1 Year Chart         MDGL Madrigal Pharmaceuticals Inc 4 - $235.06 $526,015,000 1,969,798 6.6% 70,243,000 0 9.979    Diagnostic Substances
   (RYTM)1 Year Chart         RYTM Rhythm Pharmaceuticals, Inc. 5 - $37.84 $277,241,000 6,398,365 3.48% -16,892,000 0 9.02    N/A
   (KYMR)1 Year Chart         KYMR Kymera Therapeutics, Inc. 7 - $0.00 $241,036,000 5,995,928 3.02% 88,380,000 0 9.618    N/A
   (KOD)1 Year Chart         KOD Kodiak Sciences Inc. 12 - $3.26 $91,053,000 17,310,490 1.14% 38,429,000 0 38.64    N/A
   (REPL)1 Year Chart         REPL Replimune Group Inc 14 - $5.93 $77,985,000 9,545,336 0.98% -2,482,000 0 15.549    N/A
   (TRDA)1 Year Chart         TRDA Entrada Therapeutics, Inc. 16 - $0.00 $68,949,000 4,865,819 0.86% -4,476,000 0 15.59    N/A
   (RARE)1 Year Chart         RARE Ultragenyx Pharmaceutical Inc 18 - $41.08 $68,473,000 1,466,547 0.86% -1,657,000 0 1.786    Restaurants
   (CERE)1 Year Chart         CERE Cerevel Therapeutics Holdin... 20 - $41.65 $67,632,000 1,600,000 0.85% -208,000 0 1.024    N/A
   (ARGX)1 Year Chart         ARGX Argenx Se 21 - $363.73 $59,536,000 151,215 0.75% 2,009,000 0 0.322    N/A
   (NRIX)1 Year Chart         NRIX Nurix Therapeutics, Inc. 22 - $0.00 $57,067,000 3,882,125 0.72% 17,003,000 0 8.253    N/A
   (KNSA)1 Year Chart         KNSA Kiniksa Pharmaceuticals, Ltd. 23 - $19.27 $55,433,000 2,809,577 0.7% 6,153,000 0 7.934    N/A
   (BCRX)1 Year Chart         BCRX Biocryst Pharmaceuticals Inc 24 - $6.66 $51,441,000 10,126,176 0.65% -9,215,000 0 5.344    Biotechnology
   (AVTE)1 Year Chart         AVTE Aerovate Therapeutics, Inc. 25 - $0.00 $49,693,000 1,680,517 0.62% 11,663,000 0 6.073    N/A
   (SERA)1 Year Chart         SERA Sera Prognostics, Inc. 26 - $8.20 $49,453,000 5,434,399 0.62% 16,955,000 0 18.554    N/A
   (PRLD)1 Year Chart         PRLD Prelude Therapeutics Inc 27 - $0.00 $47,987,000 10,123,824 0.6% 4,758,000 0 23.167    N/A
   (IDYA)1 Year Chart         IDYA Ideaya Biosciences, Inc. 28 - $0.00 $46,606,000 1,062,123 0.58% 8,816,000 0 1.473    N/A
   (XENE)1 Year Chart         XENE Xenon Pharmaceuticals Inc. 30 - $0.00 $42,778,000 993,679 0.54% -2,991,000 0 1.32    N/A
   (CERS)1 Year Chart         CERS Cerus Corp 32 - $1.93 $36,812,000 19,477,339 0.46% -5,259,000 0 11.653    Biotechnology
   (GLUE)1 Year Chart         GLUE Monte Rosa Therapeutics, Inc. 33 - $0.00 $34,658,000 4,916,095 0.43% 6,882,000 0 11.05    N/A
   (BMEA)1 Year Chart         BMEA Biomea Fusion, Inc. 35 - $11.50 $31,529,000 2,108,949 0.4% 907,000 0 7.33    N/A
   (KRYS)1 Year Chart         KRYS Krystal Biotech Inc 36 - $169.25 $30,236,000 169,934 0.38% 9,154,000 0 0.682    N/A
   (VERV)1 Year Chart         VERV Verve Therapeutics, Inc. 39 - $0.00 $22,464,000 1,691,530 0.28% -1,116,000 0 2.103    N/A
   (TCRX)1 Year Chart         TCRX Tscan Therapeutics, Inc. 40 - $0.00 $22,111,000 2,784,792 0.28% 5,876,000 0 6.394    N/A
   (IMVT)1 Year Chart         IMVT Immunovant Inc 42 - $0.00 $13,732,000 425,009 0.17% -4,174,000 0 0.488    N/A
   (TSVT)1 Year Chart         TSVT 2seventy Bio, Inc. 43 - $0.00 $13,362,000 2,497,526 0.17% 2,698,000 0 4.807    N/A
   (TSHA)1 Year Chart         TSHA Taysha Gene Therapies, Inc. 46 - $0.00 $11,494,000 4,004,756 0.14% 4,406,000 0 2.142    N/A
   (DBVT)1 Year Chart         DBVT DBV Technologies SA 47 - $0.62 $10,948,000 14,614,264 0.14% -2,976,000 0 13.329    N/A
   (CLDX)1 Year Chart         CLDX Celldex Therapeutics Inc 48 - $38.10 $10,394,000 247,644 0.13% 572,000 0 0.394    Diagnostic Substances
   (RLAY)1 Year Chart         RLAY Relay Therapeutics, Inc. 49 - $7.53 $9,629,000 1,160,117 0.12% -3,144,000 0 0.857    N/A
   (INSM)1 Year Chart         INSM Insmed Inc 50 - $24.16 $9,306,000 343,000 0.12% -1,324,000 0 0.226    Biotechnology
   (ATHA)1 Year Chart         ATHA Athira Pharma, Inc. 53 - $0.00 $8,641,000 3,153,807 0.11% 977,000 0 10.233    N/A
   (PRAX)1 Year Chart         PRAX Praxis Precision Medicines,... 55 - $0.00 $8,026,000 131,533 0.1% 5,095,000 0 0.251    N/A
   (PRME)1 Year Chart         PRME Prime Medicine, Inc. 58 - $7.45 $7,199,000 1,028,466 0.09% -1,913,000 0 1.058    N/A
   (TNGX)1 Year Chart         TNGX Tango Therapeutics Ord Shs 60 - $0.00 $5,955,000 750,000 0.07% -1,470,000 0 0.735    N/A
   (HOOK)1 Year Chart         HOOK Hookipa Pharma Inc. 61 - $0.00 $5,787,000 8,128,151 0.07% -797,000 0 15.975    N/A
   (MRSN)1 Year Chart         MRSN Mersana Therapeutics, Inc. 62 - $2.57 $4,866,000 1,086,115 0.06% 2,346,000 0 0.901    N/A
   (MIRM)1 Year Chart         MIRM Mirum Pharmaceuticals, Inc. 63 - $0.00 $4,785,000 190,476 0.06% -838,000 0 0.355    N/A
   (TLIS)1 Year Chart         TLIS Talis Biomedical Corp 64 - $0.00 $4,448,000 508,323 0.06% 661,000 0 2.165    N/A
   (PCVX)1 Year Chart         PCVX Vaxcyte, Inc. 65 - $0.00 $3,339,000 48,885 0.04% 269,000 0 0.045    N/A
   (IPSC)1 Year Chart         IPSC Century Therapeutics, Inc. 66 - $0.00 $3,333,000 797,460 0.04% 685,000 0 1.455    N/A
   (LPTX)1 Year Chart         LPTX Leap Therapeutics, Inc. 69 - $2.50 $3,118,000 1,172,175 0.04% -1,741,000 0 1.965    N/A
   (CMPX)1 Year Chart         CMPX Compass Therapeutics Ord Shs 70 - $0.00 $3,084,000 1,557,630 0.04% 654,000 0 1.589    N/A
   (KALA)1 Year Chart         KALA Kala Pharmaceuticals, Inc. 73 - $6.51 $2,125,000 266,613 0.03% 259,000 0 17.563    N/A
   (ALGS)1 Year Chart         ALGS Aligos Therapeutics, Inc. 74 - $0.00 $2,035,000 2,076,400 0.03% 656,000 0 2.883    N/A
   (PFE)1 Year Chart         PFE Pfizer Inc 79 - $29.60 $971,000 35,000 0.01% -37,000 0 0.001    Drug Manufacturers - ...
   (TARA)1 Year Chart         TARA Protara Therapeutics, Inc 80 - $2.99 $801,000 199,671 0.01% 427,000 0 1.9    N/A
   (PMVP)1 Year Chart         PMVP Pmv Pharmaceuticals, Inc. 81 - $0.00 $547,000 322,024 0.01% -451,000 0 0.592    N/A
   (FHTX)1 Year Chart         FHTX Foghorn Therapeutics Inc. 83 - $0.00 $302,000 45,027 0% 12,000 0 0.122    N/A
   (CABA)1 Year Chart         CABA Cabaletta Bio, Inc. 84 - $0.00 $227,000 13,331 0% -76,000 0 0.026    N/A
   (TYRA)1 Year Chart         TYRA Tyra Biosciences, Inc. 86 - $0.00 $174,000 10,607 0% 27,000 0 0.026    N/A
   (SRZNW)1 Year Chart         SRZNW Surrozen Equity Warrant Exp... 87 - $0.00 $25,000 833,333 0% 9,000 0 9.259    N/A
      53 Records Found
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