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  Name: BAKER BROS ADVISORS LLC
  City: NEW YORK
  State: NY
  Zip: 10021
   
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Portfolio Summary View Filing
  Filing Report Date : 2023-12-31
  Total Value : $8,651,176,000
  Total Value Change : $-8,563,281,000
  Securities Held Change : -17
   
All Securities Held : 82
  New Positions : 4
  Closed Positions : 21
  Increased Positions : 23
  Unchanged Positions : 42
  Decreased Positions : 13

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Holdings Found : 13     View All Holdings Currently Viewing:  Decreased Positions     Page 1 of 1
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 Ticker Company Name Position
Rank		 New/Closed
Postion
Last
Close
     Value Shares Held
% of
Portfolio
Value
Change
Change In
Shares Held
    % of Company    Industry
   (BGNE)1 Year Chart         BGNE Beigene Ltd 2 - $148.56 $1,906,206,000 10,568,897 22.03% -192,679,000 -1,100,000 11.662    N/A
   (RYTM)1 Year Chart         RYTM Rhythm Pharmaceuticals, Inc. 5 - $38.15 $294,133,000 6,398,365 3.4% 140,482,000 -303,984 10.429    N/A
   (ROIV)1 Year Chart         ROIV Roivant Sciences Ltd. 11 - $10.88 $85,270,000 7,593,024 0.99% -53,455,000 -4,284,147 1.097    N/A
   (BCRX)1 Year Chart         BCRX Biocryst Pharmaceuticals Inc 17 - $4.16 $60,656,000 10,126,176 0.7% -29,337,000 -2,584,642 5.735    Biotechnology
   (AVTE)1 Year Chart         AVTE Aerovate Therapeutics, Inc. 27 - $0.00 $38,030,000 1,680,517 0.44% 11,386,000 -282,962 6.339    N/A
   (NGNE)1 Year Chart         NGNE Neurogene 49 - $3.68 $8,789,000 453,516 0.1% 3,964,000 -767,898 1.083    N/A
   (OPT)1 Year Chart         OPT Opthea Ltd 55 - $3.63 $7,637,000 2,588,645 0.09% 2,949,000 -102,246 6.133    N/A
   (PRAX)1 Year Chart         PRAX Praxis Precision Medicines,... 66 - $0.00 $2,931,000 131,533 0.03% -284,000 -1,748,382 0.251    N/A
   (IPSC)1 Year Chart         IPSC Century Therapeutics, Inc. 67 - $0.00 $2,648,000 797,460 0.03% 349,000 -351,880 1.455    N/A
   (ACHL)1 Year Chart         ACHL Achilles Therapeutics Ameri... 70 - $0.00 $1,869,000 2,102,792 0.02% -458,000 -454,357 5.177    N/A
   (AADI)1 Year Chart         AADI Aadi Bioscience, Inc 76 - $1.68 $508,000 251,727 0.01% -4,283,000 -738,201 1.205    N/A
   (CABA)1 Year Chart         CABA Cabaletta Bio, Inc. 78 - $0.00 $303,000 13,331 0% -23,958,000 -1,580,669 0.052    N/A
   (BCEL)1 Year Chart         BCEL Atreca Inc 80 - $0.09 $287,000 2,177,499 0% -635,000 -1,355,261 7.261    N/A
      13 Records Found
  1    
Page 1 of 1
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