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BAKER BROS ADVISORS LLC |
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NEW YORK |
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NY |
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10021 |
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 |
Ticker |
Company Name |
Position
Rank |
New/Closed
Postion |
Last
Close |
Value |
Shares Held |
% of
Portfolio |
Value
Change |
Change In
Shares Held |
% of Company |
Industry |
|
INCY |
Incyte Corp |
1 |
- |
$58.20 |
$2,061,156,000 |
36,179,665 |
25.86% |
-210,531,000 |
543 |
16.52 |
Biotechnology |
|
|
BGNE |
Beigene Ltd |
2 |
- |
$167.92 |
$1,652,870,000 |
10,568,897 |
20.73% |
-253,336,000 |
0 |
11.662 |
N/A |
|
|
ACAD |
Acadia Pharmaceuticals Inc |
3 |
- |
$15.82 |
$792,567,000 |
42,864,612 |
9.94% |
-549,524,000 |
0 |
26.664 |
Biotechnology |
|
|
MDGL |
Madrigal Pharmaceuticals Inc |
4 |
- |
$235.06 |
$526,015,000 |
1,969,798 |
6.6% |
70,243,000 |
0 |
9.979 |
Diagnostic Substances |
|
|
RYTM |
Rhythm Pharmaceuticals, Inc. |
5 |
- |
$37.84 |
$277,241,000 |
6,398,365 |
3.48% |
-16,892,000 |
0 |
9.02 |
N/A |
|
|
RVMD |
Revolution Medicines, Inc. |
6 |
- |
$39.77 |
$243,312,000 |
7,549,249 |
3.05% |
95,649,000 |
2,400,592 |
4.609 |
N/A |
|
|
KYMR |
Kymera Therapeutics, Inc. |
7 |
- |
$0.00 |
$241,036,000 |
5,995,928 |
3.02% |
88,380,000 |
0 |
9.618 |
N/A |
|
|
ABCL |
Abcellera Biologics Inc. |
8 |
- |
$0.00 |
$124,691,000 |
27,525,640 |
1.56% |
-6,124,000 |
4,615,887 |
10.225 |
N/A |
|
|
BCYC |
Bicycle Therapeutics Ltd |
9 |
- |
$0.00 |
$123,076,000 |
4,942,823 |
1.54% |
90,706,000 |
3,152,433 |
13.104 |
N/A |
|
|
EWTX |
Edgewise Therapeutics, Inc. |
10 |
- |
$0.00 |
$106,523,000 |
5,840,059 |
1.34% |
72,469,000 |
2,727,273 |
6.329 |
N/A |
|
|
IMCR |
Immunocore Holdings Adr |
11 |
- |
$50.47 |
$98,496,000 |
1,515,318 |
1.24% |
-73,720,000 |
-1,005,413 |
3.46 |
N/A |
|
|
KOD |
Kodiak Sciences Inc. |
12 |
- |
$3.26 |
$91,053,000 |
17,310,490 |
1.14% |
38,429,000 |
0 |
38.64 |
N/A |
|
|
ROIV |
Roivant Sciences Ltd. |
13 |
- |
$11.29 |
$78,142,000 |
7,413,834 |
0.98% |
-7,128,000 |
-179,190 |
1.071 |
N/A |
|
|
REPL |
Replimune Group Inc |
14 |
- |
$5.93 |
$77,985,000 |
9,545,336 |
0.98% |
-2,482,000 |
0 |
15.549 |
N/A |
|
|
DNLI |
Denali Therapeutics Inc. |
15 |
- |
$20.06 |
$76,574,000 |
3,731,695 |
0.96% |
20,624,000 |
1,124,499 |
3.112 |
N/A |
|
|
TRDA |
Entrada Therapeutics, Inc. |
16 |
- |
$0.00 |
$68,949,000 |
4,865,819 |
0.86% |
-4,476,000 |
0 |
15.59 |
N/A |
|
|
AKRO |
Akero Therapeutics, Inc. |
17 |
- |
$0.00 |
$68,536,000 |
2,713,205 |
0.86% |
13,234,000 |
344,827 |
4.427 |
N/A |
|
|
RARE |
Ultragenyx Pharmaceutical Inc |
18 |
- |
$41.08 |
$68,473,000 |
1,466,547 |
0.86% |
-1,657,000 |
0 |
1.786 |
Restaurants |
|
|
IMTX |
Immatics N.V |
19 |
- |
$10.34 |
$67,720,000 |
6,443,398 |
0.85% |
6,237,000 |
604,545 |
10.242 |
N/A |
|
|
CERE |
Cerevel Therapeutics Holdin... |
20 |
- |
$41.65 |
$67,632,000 |
1,600,000 |
0.85% |
-208,000 |
0 |
1.024 |
N/A |
|
|
ARGX |
Argenx Se |
21 |
- |
$363.73 |
$59,536,000 |
151,215 |
0.75% |
2,009,000 |
0 |
0.322 |
N/A |
|
|
NRIX |
Nurix Therapeutics, Inc. |
22 |
- |
$0.00 |
$57,067,000 |
3,882,125 |
0.72% |
17,003,000 |
0 |
8.253 |
N/A |
|
|
KNSA |
Kiniksa Pharmaceuticals, Ltd. |
23 |
- |
$19.27 |
$55,433,000 |
2,809,577 |
0.7% |
6,153,000 |
0 |
7.934 |
N/A |
|
|
BCRX |
Biocryst Pharmaceuticals Inc |
24 |
- |
$6.66 |
$51,441,000 |
10,126,176 |
0.65% |
-9,215,000 |
0 |
5.344 |
Biotechnology |
|
|
AVTE |
Aerovate Therapeutics, Inc. |
25 |
- |
$0.00 |
$49,693,000 |
1,680,517 |
0.62% |
11,663,000 |
0 |
6.073 |
N/A |
|
|
SERA |
Sera Prognostics, Inc. |
26 |
- |
$8.20 |
$49,453,000 |
5,434,399 |
0.62% |
16,955,000 |
0 |
18.554 |
N/A |
|
|
PRLD |
Prelude Therapeutics Inc |
27 |
- |
$0.00 |
$47,987,000 |
10,123,824 |
0.6% |
4,758,000 |
0 |
23.167 |
N/A |
|
|
IDYA |
Ideaya Biosciences, Inc. |
28 |
- |
$0.00 |
$46,606,000 |
1,062,123 |
0.58% |
8,816,000 |
0 |
1.473 |
N/A |
|
|
STOK |
Stoke Therapeutics, Inc. |
29 |
- |
$0.00 |
$45,474,000 |
3,368,443 |
0.57% |
34,795,000 |
1,338,309 |
7.078 |
N/A |
|
|
XENE |
Xenon Pharmaceuticals Inc. |
30 |
- |
$0.00 |
$42,778,000 |
993,679 |
0.54% |
-2,991,000 |
0 |
1.32 |
N/A |
|
|
IGMS |
Igm Biosciences, Inc. |
31 |
- |
$0.00 |
$39,452,000 |
4,088,322 |
0.49% |
8,780,000 |
397,311 |
16.88 |
N/A |
|
|
CERS |
Cerus Corp |
32 |
- |
$1.93 |
$36,812,000 |
19,477,339 |
0.46% |
-5,259,000 |
0 |
11.653 |
Biotechnology |
|
|
GLUE |
Monte Rosa Therapeutics, Inc. |
33 |
- |
$0.00 |
$34,658,000 |
4,916,095 |
0.43% |
6,882,000 |
0 |
11.05 |
N/A |
|
|
CELC |
Celcuity Inc. |
34 |
- |
$15.99 |
$33,534,000 |
1,552,478 |
0.42% |
25,732,000 |
1,017,000 |
7.164 |
N/A |
|
|
BMEA |
Biomea Fusion, Inc. |
35 |
- |
$11.50 |
$31,529,000 |
2,108,949 |
0.4% |
907,000 |
0 |
7.33 |
N/A |
|
|
KRYS |
Krystal Biotech Inc |
36 |
- |
$169.25 |
$30,236,000 |
169,934 |
0.38% |
9,154,000 |
0 |
0.682 |
N/A |
|
|
SANA |
Sana Biotechnology, Inc. |
37 |
- |
$0.00 |
$23,809,000 |
2,380,949 |
0.3% |
15,649,000 |
380,949 |
1.27 |
N/A |
|
|
NGNE |
Neurogene |
38 |
- |
$3.68 |
$23,211,000 |
456,015 |
0.29% |
14,422,000 |
2,499 |
1.089 |
N/A |
|
|
VERV |
Verve Therapeutics, Inc. |
39 |
- |
$0.00 |
$22,464,000 |
1,691,530 |
0.28% |
-1,116,000 |
0 |
2.103 |
N/A |
|
|
TCRX |
Tscan Therapeutics, Inc. |
40 |
- |
$0.00 |
$22,111,000 |
2,784,792 |
0.28% |
5,876,000 |
0 |
6.394 |
N/A |
|
|
ADAP |
Adaptimmune Therapeutics PLC |
41 |
- |
$1.05 |
$17,043,000 |
10,787,022 |
0.21% |
8,344,000 |
-182,260 |
6.975 |
N/A |
|
|
IMVT |
Immunovant Inc |
42 |
- |
$0.00 |
$13,732,000 |
425,009 |
0.17% |
-4,174,000 |
0 |
0.488 |
N/A |
|
|
TSVT |
2seventy Bio, Inc. |
43 |
- |
$0.00 |
$13,362,000 |
2,497,526 |
0.17% |
2,698,000 |
0 |
4.807 |
N/A |
|
|
FATE |
Fate Therapeutics Inc |
44 |
New |
$3.65 |
$13,345,000 |
1,818,181 |
0.17% |
13,345,000 |
1,818,181 |
1.534 |
Biotechnology |
|
|
XNCR |
Xencor Inc |
45 |
- |
$24.50 |
$12,070,000 |
545,431 |
0.15% |
6,859,000 |
300,000 |
0.822 |
Biotechnology |
|
|
TSHA |
Taysha Gene Therapies, Inc. |
46 |
- |
$0.00 |
$11,494,000 |
4,004,756 |
0.14% |
4,406,000 |
0 |
2.142 |
N/A |
|
|
DBVT |
DBV Technologies SA |
47 |
- |
$0.62 |
$10,948,000 |
14,614,264 |
0.14% |
-2,976,000 |
0 |
13.329 |
N/A |
|
|
CLDX |
Celldex Therapeutics Inc |
48 |
- |
$38.10 |
$10,394,000 |
247,644 |
0.13% |
572,000 |
0 |
0.394 |
Diagnostic Substances |
|
|
RLAY |
Relay Therapeutics, Inc. |
49 |
- |
$7.53 |
$9,629,000 |
1,160,117 |
0.12% |
-3,144,000 |
0 |
0.857 |
N/A |
|
|
INSM |
Insmed Inc |
50 |
- |
$24.16 |
$9,306,000 |
343,000 |
0.12% |
-1,324,000 |
0 |
0.226 |
Biotechnology |
|
|
OPT |
Opthea Ltd |
51 |
- |
$3.27 |
$8,951,000 |
2,177,826 |
0.11% |
1,314,000 |
-410,819 |
5.16 |
N/A |
|
|
NMRA |
Neumora Therapeutics, Inc. |
52 |
New |
$9.65 |
$8,715,000 |
633,851 |
0.11% |
8,715,000 |
633,851 |
0.415 |
N/A |
|
|
ATHA |
Athira Pharma, Inc. |
53 |
- |
$0.00 |
$8,641,000 |
3,153,807 |
0.11% |
977,000 |
0 |
10.233 |
N/A |
|
|
DYN |
Dyne Therapeutics, Inc. |
54 |
New |
$31.53 |
$8,091,000 |
285,000 |
0.1% |
8,091,000 |
285,000 |
0.351 |
N/A |
|
|
PRAX |
Praxis Precision Medicines,... |
55 |
- |
$0.00 |
$8,026,000 |
131,533 |
0.1% |
5,095,000 |
0 |
0.251 |
N/A |
|
|
SAGE |
Sage Therapeutics, Inc. |
56 |
New |
$0.00 |
$7,631,000 |
407,217 |
0.1% |
7,631,000 |
407,217 |
0.699 |
N/A |
|
|
SGMT |
Sagimet Biosciences Inc. |
57 |
- |
$5.08 |
$7,490,000 |
1,381,898 |
0.09% |
-404,000 |
-74,620 |
6.47 |
N/A |
|
|
PRME |
Prime Medicine, Inc. |
58 |
- |
$7.45 |
$7,199,000 |
1,028,466 |
0.09% |
-1,913,000 |
0 |
1.058 |
N/A |
|
|
DSGN |
Design Therapeutics, Inc. |
59 |
- |
$0.00 |
$6,698,000 |
1,662,120 |
0.08% |
2,723,000 |
162,120 |
2.988 |
N/A |
|
|
TNGX |
Tango Therapeutics Ord Shs |
60 |
- |
$0.00 |
$5,955,000 |
750,000 |
0.07% |
-1,470,000 |
0 |
0.735 |
N/A |
|
|
HOOK |
Hookipa Pharma Inc. |
61 |
- |
$0.00 |
$5,787,000 |
8,128,151 |
0.07% |
-797,000 |
0 |
15.975 |
N/A |
|
|
MRSN |
Mersana Therapeutics, Inc. |
62 |
- |
$2.57 |
$4,866,000 |
1,086,115 |
0.06% |
2,346,000 |
0 |
0.901 |
N/A |
|
|
MIRM |
Mirum Pharmaceuticals, Inc. |
63 |
- |
$0.00 |
$4,785,000 |
190,476 |
0.06% |
-838,000 |
0 |
0.355 |
N/A |
|
|
TLIS |
Talis Biomedical Corp |
64 |
- |
$0.00 |
$4,448,000 |
508,323 |
0.06% |
661,000 |
0 |
2.165 |
N/A |
|
|
PCVX |
Vaxcyte, Inc. |
65 |
- |
$0.00 |
$3,339,000 |
48,885 |
0.04% |
269,000 |
0 |
0.045 |
N/A |
|
|
IPSC |
Century Therapeutics, Inc. |
66 |
- |
$0.00 |
$3,333,000 |
797,460 |
0.04% |
685,000 |
0 |
1.455 |
N/A |
|
|
ALPN |
Alpine Immune Sciences Inc |
67 |
New |
$64.97 |
$3,234,000 |
81,578 |
0.04% |
3,234,000 |
81,578 |
0.124 |
N/A |
|
|
FDMT |
4d Molecular Therapeutics Inc. |
68 |
New |
$0.00 |
$3,186,000 |
100,000 |
0.04% |
3,186,000 |
100,000 |
0.203 |
N/A |
|
|
LPTX |
Leap Therapeutics, Inc. |
69 |
- |
$2.50 |
$3,118,000 |
1,172,175 |
0.04% |
-1,741,000 |
0 |
1.965 |
N/A |
|
|
CMPX |
Compass Therapeutics Ord Shs |
70 |
- |
$0.00 |
$3,084,000 |
1,557,630 |
0.04% |
654,000 |
0 |
1.589 |
N/A |
|
|
NAMS |
Newamsterdam Pharma Ord Shs |
71 |
New |
$0.00 |
$2,290,000 |
96,827 |
0.03% |
2,290,000 |
96,827 |
0.337 |
N/A |
|
|
VTVT |
Vtv Therapeutics Inc. |
72 |
New |
$0.35 |
$2,290,000 |
97,314 |
0.03% |
2,290,000 |
97,314 |
0 |
N/A |
|
|
KALA |
Kala Pharmaceuticals, Inc. |
73 |
- |
$6.51 |
$2,125,000 |
266,613 |
0.03% |
259,000 |
0 |
17.563 |
N/A |
|
|
ALGS |
Aligos Therapeutics, Inc. |
74 |
- |
$0.00 |
$2,035,000 |
2,076,400 |
0.03% |
656,000 |
0 |
2.883 |
N/A |
|
|
ELVN |
Enliven Therapeutics Ord Shs |
75 |
New |
$0.00 |
$2,020,000 |
114,833 |
0.03% |
2,020,000 |
114,833 |
0.279 |
N/A |
|
|
ACHL |
Achilles Therapeutics Ameri... |
76 |
- |
$0.00 |
$1,511,000 |
1,208,775 |
0.02% |
-358,000 |
-894,017 |
3.601 |
N/A |
|
|
GBIO |
Generation Bio Co. |
77 |
New |
$0.00 |
$1,511,000 |
371,219 |
0.02% |
1,511,000 |
371,219 |
0 |
N/A |
|
|
MURA |
Mural Oncology Plc |
78 |
New |
$3.77 |
$1,088,000 |
222,503 |
0.01% |
1,088,000 |
222,503 |
1.333 |
N/A |
|
|
PFE |
Pfizer Inc |
79 |
- |
$29.60 |
$971,000 |
35,000 |
0.01% |
-37,000 |
0 |
0.001 |
Drug Manufacturers - ... |
|
|
TARA |
Protara Therapeutics, Inc |
80 |
- |
$2.99 |
$801,000 |
199,671 |
0.01% |
427,000 |
0 |
1.9 |
N/A |
|
|
PMVP |
Pmv Pharmaceuticals, Inc. |
81 |
- |
$0.00 |
$547,000 |
322,024 |
0.01% |
-451,000 |
0 |
0.592 |
N/A |
|
|
ACRV |
Acrivon Therapeutics, Inc. |
82 |
New |
$8.57 |
$378,000 |
52,885 |
0% |
378,000 |
52,885 |
0.253 |
N/A |
|
|
FHTX |
Foghorn Therapeutics Inc. |
83 |
- |
$0.00 |
$302,000 |
45,027 |
0% |
12,000 |
0 |
0.122 |
N/A |
|
|
CABA |
Cabaletta Bio, Inc. |
84 |
- |
$0.00 |
$227,000 |
13,331 |
0% |
-76,000 |
0 |
0.026 |
N/A |
|
|
ISR |
IsoRay, Inc. |
85 |
- |
$1.49 |
$178,000 |
149,787 |
0% |
-2,893,000 |
-7,489,916 |
0.272 |
Medical Instruments &... |
|
|
TYRA |
Tyra Biosciences, Inc. |
86 |
- |
$0.00 |
$174,000 |
10,607 |
0% |
27,000 |
0 |
0.026 |
N/A |
|
|
SRZNW |
Surrozen Equity Warrant Exp... |
87 |
- |
$0.00 |
$25,000 |
833,333 |
0% |
9,000 |
0 |
9.259 |
N/A |
|
|
DAWN |
Day One Biopharmaceuticals,... |
93 |
Closed |
$0.00 |
$0 |
0 |
0% |
-14,600,000 |
-1,000,000 |
0 |
N/A |
|
|
SBTX |
Silverback Therapeutics, Inc. |
89 |
Closed |
$0.00 |
$0 |
0 |
0% |
-10,995,000 |
-2,006,451 |
0 |
N/A |
|
|
GRCL |
Gracell Biotechnologies Adr... |
92 |
Closed |
$0.00 |
$0 |
0 |
0% |
-20,883,000 |
-2,080,000 |
0 |
N/A |
|
|
AADI |
Aadi Bioscience, Inc |
88 |
Closed |
$1.93 |
$0 |
0 |
0% |
-508,000 |
-251,727 |
0 |
N/A |
|
|
NVTA |
Invitae Corp |
91 |
Closed |
$0.00 |
$0 |
0 |
0% |
-1,106,000 |
-1,764,546 |
0 |
N/A |
|
|
MRTX |
Mirati Therapeutics, Inc. |
94 |
Closed |
$58.70 |
$0 |
0 |
0% |
-242,135,000 |
-4,121,440 |
0 |
Biotechnology |
|
|
BCEL |
Atreca Inc |
90 |
Closed |
$0.09 |
$0 |
0 |
0% |
-287,000 |
-2,177,499 |
0 |
N/A |
|
