Opaleye Management Inc. : Portfolio Holdings

Portfolio Summary	View Filing
Filing Report Date :	2023-12-31
Total Value :	$373,152,000
Total Value Change :	$65,773,000
Securities Held Change :	5

All Securities Held :	45
New Positions :	10
Closed Positions :	7
Increased Positions :	14
Unchanged Positions :	7
Decreased Positions :	14

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Holdings Found : 52		View All Holdings	Currently Viewing: ALL				Page 1 of 1

Menu	Ticker	Company Name	Position Rank	New/Closed Postion	Last Close	Value	Shares Held	% of Portfolio	Value Change	Change In Shares Held	% of Company	Industry
	HROW	Harrow Health Inc	1	-	$10.27	$42,784,000	3,820,000	11.47%	-11,750,000	25,000	14.835	Biotechnology
	TGTX	TG Therapeutics Inc	2	-	$13.98	$37,832,000	2,215,000	10.14%	22,032,000	325,000	1.718	Drug Manufacturers - ...
	SLRN	Acelyrin, Inc.	3	-	$4.57	$30,930,000	4,146,138	8.29%	-11,236,000	0	4.266	N/A
	RYTM	Rhythm Pharmaceuticals, Inc.	4	-	$39.71	$28,042,000	610,000	7.51%	13,072,000	-43,000	0.994	N/A
	OCUL	Ocular Therapeutix, Inc	5	-	$0.00	$27,072,000	6,070,000	7.25%	6,762,000	-398,000	8.503	N/A
	CPRX	Catalyst Pharmaceutical Par...	6	-	$15.12	$21,436,000	1,257,200	5.74%	7,350,000	52,200	1.213	Drugs - Generic
	KROS	Keros Therapeutics, Inc.	7	-	$0.00	$14,214,000	357,500	3.81%	2,724,000	-2,900	1.052	N/A
	IDYA	Ideaya Biosciences, Inc.	8	-	$0.00	$11,083,000	311,500	2.97%	2,679,000	0	0.647	N/A
	ETON	Eton Pharmaceuticals, Inc.	9	-	$0.00	$11,081,000	2,529,887	2.97%	947,000	99,617	14.366	N/A
	CRNX	Crinetics Pharmaceuticals, ...	10	-	$43.32	$10,941,000	307,500	2.93%	-63,000	-62,500	0.53	N/A
	ARVN	Arvinas Holding Company, Llc	11	New	$32.54	$10,854,000	263,700	2.91%	10,854,000	263,700	0.496	N/A
	CDXS	Codexis Inc	12	-	$2.80	$9,289,000	3,045,525	2.49%	7,174,000	1,926,625	4.694	Biotechnology
	BHVN	Biohaven Ltd.	13	-	$38.72	$8,560,000	200,000	2.29%	-2,858,000	-239,000	0.293	N/A
	EWTX	Edgewise Therapeutics, Inc.	14	-	$0.00	$7,647,000	699,000	2.05%	2,631,000	-176,405	1.001	N/A
	IOVA	Iovance Biotherapeutics Inc	15	-	$11.71	$7,293,000	897,000	1.95%	4,517,000	287,000	0.419	N/A
	ARQT	Arcutis Biotherapeutics, Inc.	16	New	$8.75	$6,331,000	1,960,000	1.7%	6,331,000	1,960,000	2.61	N/A
	FDMT	4d Molecular Therapeutics Inc.	17	-	$0.00	$6,250,000	308,500	1.67%	2,323,000	0	0.952	N/A
	MRNS	Marinus Pharmaceuticals Inc	18	-	$1.44	$6,125,000	563,500	1.64%	1,424,000	-20,500	1.136	N/A
	PCVX	Vaxcyte, Inc.	19	-	$0.00	$5,652,000	90,000	1.51%	1,064,000	0	0.083	N/A
	LQDA	Liquidia Technologies Inc	20	-	$12.55	$5,353,000	445,000	1.43%	1,735,000	-125,700	1.179	N/A
	TARA	Protara Therapeutics, Inc	21	-	$2.82	$5,049,000	2,692,594	1.35%	552,000	0	25.619	N/A
	URGN	Urogen Pharma Ltd.	22	-	$14.21	$4,800,000	320,000	1.29%	317,000	0	1.449	N/A
	XOMA	XOMA Corporation	23	-	$25.64	$4,625,000	250,000	1.24%	757,000	-24,500	2.218	Biotechnology
	APLT	Applied Therapeutics Inc.	24	-	$0.00	$3,660,000	1,092,500	0.98%	1,436,000	199,500	2.276	N/A
	RLMD	Relmada Therapeutics, Inc.	25	-	$3.86	$3,631,000	877,000	0.97%	3,541,000	847,000	3.163	N/A
	BDSX	Biodesix Inc	26	-	$0.00	$3,611,000	496,500	0.97%	573,000	40,927	1.871	N/A
	TRVI	Trevi Therapeutics, Inc.	27	-	$0.00	$3,397,000	2,535,000	0.91%	-322,000	829,100	4.231	N/A
	JSPR	Jasper Therapeutics Ord Shs	28	New	$15.12	$3,144,000	3,985,340	0.84%	3,144,000	3,985,340	3.923	N/A
	NTLA	Intellia Therapeutics, Inc.	29	-	$21.17	$3,019,000	99,000	0.81%	3,019,000	99,000	0.111	N/A
	NAMS	Newamsterdam Pharma Ord Shs	30	New	$0.00	$2,964,000	265,388	0.79%	2,964,000	265,388	0.325	N/A
	LRMR	Larimar Therapeutics Inc	31	-	$1.15	$2,837,000	623,500	0.76%	-515,000	-225,000	1.561	N/A
	VTYX	Ventyx Biosciences, Inc.	32	New	$4.24	$2,816,000	1,140,000	0.75%	2,816,000	1,140,000	2.267	N/A
	SYRS	Syros Pharmaceuticals, Inc.	33	New	$5.07	$2,799,000	359,370	0.75%	2,799,000	359,370	0.639	N/A
	GOSS	Gossamer Bio Inc	34	-	$0.71	$2,721,000	2,982,200	0.73%	-1,238,000	-1,772,000	3.156	N/A
	PTGX	Protagonist Therapeutics, Inc	35	New	$25.70	$2,584,000	112,700	0.69%	2,584,000	112,700	0.2	N/A
	KALV	Kalvista Pharmaceuticals Inc	36	-	$10.35	$1,838,000	150,000	0.49%	-2,977,000	-350,000	0.444	N/A
	VSTM	Verastem, Inc.	37	-	$9.31	$1,721,000	211,400	0.46%	2,000	0	0.838	Biotechnology
	NYXH	Nyxoah Ord Shs	38	-	$0.00	$1,600,000	344,800	0.43%	-1,515,000	-97,096	1.35	N/A
	MOR	Morphosys Ag	39	-	$18.05	$1,436,000	145,000	0.38%	-6,691,000	-1,064,380	0.111	N/A
	PGEN	Precigen Inc	40	-	$1.42	$1,357,000	1,012,500	0.36%	39,000	84,000	0.567	Biotechnology
	STRO	Sutro Biopharma Inc	41	-	$3.47	$1,293,000	301,491	0.35%	1,293,000	301,491	0.536	N/A
	CNTX	Context Therapeutics Inc.	42	New	$0.00	$1,102,000	975,000	0.3%	1,102,000	975,000	6.109	N/A
	FULC	Fulcrum Therapeutics, Inc.	43	-	$0.00	$878,000	130,000	0.24%	878,000	130,000	0.206	N/A
	ALGS	Aligos Therapeutics, Inc.	44	New	$0.00	$861,000	1,297,000	0.23%	861,000	1,297,000	3.703	N/A
	KNSA	Kiniksa Pharmaceuticals, Ltd.	45	New	$17.86	$640,000	37,500	0.17%	640,000	37,500	0.111	N/A
	IGMS	Igm Biosciences, Inc.	46	Closed	$0.00	$0	0	0%	-2,179,000	-261,000	0	N/A
	KZR	Kezar Life Sciences, Inc.	51	Closed	$0.80	$0	0	0%	-506,000	-425,000	0	N/A
	GERN	Geron Corporation	50	Closed	$3.58	$0	0	0%	-4,060,000	-1,915,000	0	Drug Manufacturers - ...
	FBIO	Fortress Biotech, Inc.	52	Closed	$0.29	$0	0	0%	-581,000	-2,000,000	0	Biotechnology
	TELA	Tela Bio, Inc.	49	Closed	$4.45	$0	0	0%	-6,000,000	-750,000	0	N/A
	TCON	Tracon Pharmaceuticals, Inc.	48	Closed	$0.26	$0	0	0%	-848,000	-4,764,508	0	N/A
	XERS	Xeris Pharmaceuticals Inc	47	Closed	$1.76	$0	0	0%	-725,000	-390,000	0	N/A

52 Records Found

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