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  Name: BAKER BROS ADVISORS LLC
  City: NEW YORK
  State: NY
  Zip: 10021
   
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Portfolio Summary View Filing
  Filing Report Date : 2015-03-31
  Total Value : $9,383,500,000
  Total Value Change : $1,647,820,000
  Securities Held Change : 8
   
All Securities Held : 118
  New Positions : 18
  Closed Positions : 10
  Increased Positions : 23
  Unchanged Positions : 26
  Decreased Positions : 51
 
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Holdings Found : 100     View All Holdings Currently Viewing:  ALL     Page 1 of 1
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Ticker Company Name Position
Rank
New/Closed
Postion
Last
Close
    Value Shares Held
% of
Portfolio
Value
Change
Change In
Shares Held
   % of Company    Industry
   (PCYC)1 Year Chart         PCYC Pharmacyclics Inc 1 - $259.55 $2,313,699,000 9,039,652 24.66% 1,197,559,000 -89,579 12.285    Drug Manufacturers - ...
   (INCY)1 Year Chart         INCY Incyte Corp 2 - $108.41 $1,360,744,000 14,845,559 14.5% 275,385,000 0 9.228    Biotechnology
   (GEVA)1 Year Chart         GEVA Synageva BioPharma Corp 3 - $215.79 $1,137,242,000 11,660,432 12.12% 148,060,000 1,000,000 34.295    Biotechnology
   (SGEN)1 Year Chart         SGEN Seattle Genetics Inc 4 - $43.76 $1,020,792,000 28,876,712 10.88% 125,595,000 1,014,992 23.288    Biotechnology
   (ACAD)1 Year Chart         ACAD Acadia Pharmaceuticals Inc 5 - $40.22 $667,490,000 20,481,442 7.11% 17,204,000 0 20.481    Biotechnology
   (BMRN)1 Year Chart         BMRN Biomarin Pharmaceutical Inc 6 - $126.88 $523,461,000 4,200,456 5.58% 187,720,000 486,506 2.838    Drug Manufacturers - ...
   (GHDX)1 Year Chart         GHDX Genomic Health Inc 7 - $27.11 $417,220,000 13,656,942 4.45% -19,372,000 624 44.43    Biotechnology
   (ANAC)1 Year Chart         ANAC Anacor Pharmaceuticals Inc 8 - $63.42 $243,242,000 4,204,702 2.59% 107,640,000 0 10.32    Biotechnology
   (NVTA)1 Year Chart         NVTA Invitae Corp 9 New $14.62 $109,861,000 6,554,967 1.17% 109,861,000 6,554,967 20.607    N/A
   (ONCE)1 Year Chart         ONCE Spark Therapeutics, Inc. 10 New $68.45 $102,878,000 1,327,451 1.1% 102,878,000 1,327,451 5.409    N/A
   (DYAX)1 Year Chart         DYAX DYAX Corp 11 - $26.77 $100,890,000 6,021,485 1.08% 14,311,000 -136,304 4.395    Biotechnology
   (BLCM)1 Year Chart         BLCM Bellicum Pharmaceuticals, Inc 12 - $23.86 $97,096,000 4,190,594 1.03% -1,601,000 -93,138 16.211    N/A
   (BCRX)1 Year Chart         BCRX Biocryst Pharmaceuticals Inc 13 - $11.30 $94,618,000 10,478,204 1.01% -35,660,000 -235,482 17.732    Biotechnology
   (MRTX)1 Year Chart         MRTX Mirati Therapeutics, Inc. 14 - $25.84 $82,245,000 2,805,074 0.88% 38,166,000 425,000 20.809    Biotechnology
   (CERS)1 Year Chart         CERS Cerus Corp 15 - $4.55 $56,517,000 13,553,275 0.6% -16,508,000 1,850,548 19.237    Biotechnology
   (VSAR)1 Year Chart         VSAR Versartis, Inc. 16 - $15.00 $54,694,000 2,977,396 0.58% 3,469,000 695,652 12.801    N/A
   (XOMA)1 Year Chart         XOMA XOMA Corporation 17 - $3.39 $53,539,000 14,708,613 0.57% -7,218,000 -2,215,400 15.867    Biotechnology
   (XNPT)1 Year Chart         XNPT Xenoport Inc 18 - $6.27 $46,341,000 6,508,622 0.49% -14,204,000 -395,006 10.516    Drug Related Products
   (ARRY)1 Year Chart         ARRY Array Biopharma Inc 19 - $7.38 $41,705,000 5,658,755 0.44% 34,923,000 4,224,958 4.535    Medical Laboratories ...
   (HRTX)1 Year Chart         HRTX Heron Therapeutics Inc 20 - $12.69 $37,943,000 2,607,784 0.4% 11,709,000 0 1.304    Synthetics
   (DBVT)1 Year Chart         DBVT DBV Technologies SA 21 - $25.09 $35,489,000 1,519,229 0.38% -5,712,000 0 4.118    N/A
   (INSM)1 Year Chart         INSM Insmed Inc 22 - $22.76 $32,937,000 1,583,490 0.35% 15,799,000 475,640 3.189    Biotechnology
   (CPRX)1 Year Chart         CPRX Catalyst Pharmaceutical Par... 23 - $3.94 $32,758,000 7,565,462 0.35% 12,813,000 850,000 11.265    Drugs - Generic
   (HALO)1 Year Chart         HALO Halozyme Therapeutics Inc 24 - $17.25 $32,104,000 2,248,152 0.34% 5,314,000 -527,991 1.972    Biotechnology
   (TGTX)1 Year Chart         TGTX TG Therapeutics Inc 25 - $16.00 $31,739,000 2,050,313 0.34% -738,000 0 6.139    Drug Manufacturers - ...
   (DSCI)1 Year Chart         DSCI Derma Sciences Inc 26 - $6.56 $29,288,000 3,457,841 0.31% -3,643,000 -79,296 13.733    Drug Manufacturers - ...
   (PGNX)1 Year Chart         PGNX Progenics Pharmaceuticals Inc 27 - $5.54 $26,018,000 4,350,808 0.28% -7,622,000 -98,989 7.153    Drug Manufacturers - ...
   (IDRA)1 Year Chart         IDRA Idera Pharmaceuticals Inc 28 - $3.04 $25,842,000 6,965,432 0.28% 18,661,000 5,337,260 11.112    Biotechnology
   (ALDR)1 Year Chart         ALDR Alder Biopharmaceuticals Inc 29 - $38.80 $25,385,000 879,581 0.27% 20,924,000 726,231 2.856    N/A
   (ACOR)1 Year Chart         ACOR Acorda Therapeutics Inc 30 - $32.26 $24,591,000 738,916 0.26% -6,288,000 -16,618 1.759    Biotechnology
   (GILD)1 Year Chart         GILD Gilead Sciences Inc 31 - $111.22 $24,532,000 249,995 0.26% 391,000 -6,113 0.016    Biotechnology
   (SGMO)1 Year Chart         SGMO Sangamo Biosciences Inc 32 - $12.45 $22,023,000 1,404,544 0.23% 7,492,000 449,212 2.287    Biotechnology
   (NBIX)1 Year Chart         NBIX Neurocrine Biosciences Inc 33 - $41.98 $21,532,000 542,236 0.23% 9,142,000 -12,354 0.713    Biotechnology
   (KYTH)1 Year Chart         KYTH Kythera Biopharmaceuticals Inc 34 - $49.41 $17,766,000 354,265 0.19% 7,839,000 68,010 1.887    Drug Manufacturers - ...
   (BLUE)1 Year Chart         BLUE Bluebird Bio, Inc. 35 - $172.94 $17,703,000 146,581 0.19% 3,945,000 -3,419 0.45    Biotechnology
   (RPRX)1 Year Chart         RPRX Repros Therapeutics 36 - $7.66 $17,180,000 2,000,000 0.18% -2,760,000 0 8.692    Biotechnology
   (FOMX)1 Year Chart         FOMX Foamix Pharmaceuticals Ltd 37 - $11.60 $16,853,000 1,821,967 0.18% 9,692,000 800,367 8.482    N/A
   (VNDA)1 Year Chart         VNDA Vanda Pharmaceuticals Inc. 38 - $10.26 $16,277,000 1,750,230 0.17% -47,764,000 -2,721,923 3.487    Biotechnology
   (NVAX)1 Year Chart         NVAX Novavax Inc 39 - $8.86 $16,091,000 1,945,687 0.17% 8,836,000 722,325 0.933    Biotechnology
   (LBIO)1 Year Chart         LBIO Lion Biotechnologies, Inc. 40 New $10.67 $16,046,000 1,325,000 0.17% 16,046,000 1,325,000 8.791    N/A
   (CLVS)1 Year Chart         CLVS Clovis Oncology, Inc. 41 - $90.53 $15,041,000 202,630 0.16% 3,694,000 0 0.672    Biotechnology
   (AGIO)1 Year Chart         AGIO Agios Pharmaceuticals Inc 42 - $115.06 $14,141,000 149,954 0.15% -4,166,000 -13,439 0.483    N/A
   (OMER)1 Year Chart         OMER Omeros Corp 43 - $21.22 $14,043,000 637,446 0.15% -2,017,000 -10,655 2.136    Drug Manufacturers - ...
   (XNCR)1 Year Chart         XNCR Xencor Inc 44 - $16.79 $13,360,000 872,072 0.14% 3,874,000 280,701 2.781    Biotechnology
   (THLD)1 Year Chart         THLD Threshold Pharmaceuticals Inc 45 - $3.91 $11,878,000 2,925,519 0.13% 5,023,000 770,003 4.944    Diagnostic Substances
   (ADHD)1 Year Chart         ADHD Alcobra Pharmaceuticals 46 - $6.29 $10,077,000 1,789,871 0.11% 8,996,000 1,500,000 13.122    N/A
   (AQXP)1 Year Chart         AQXP Aquinox Pharmaceuticals, Inc 47 - $7.25 $9,763,000 1,187,666 0.1% 685,000 -22,684 11.829    N/A
   (MGNX)1 Year Chart         MGNX Macrogenics Inc 48 - $31.13 $9,569,000 305,043 0.1% -1,369,000 -6,848 1.211    Biotechnology
   (AERI)1 Year Chart         AERI Aerie Pharmaceuticals Inc 49 - $11.25 $9,382,000 299,356 0.1% 644,000 0 1.286    Drug Manufacturers - ...
   (RARE)1 Year Chart         RARE Ultragenyx Pharmaceutical Inc 50 - $84.89 $9,245,000 148,894 0.1% 2,663,000 -1,106 0.496    Restaurants
   (IMGN)1 Year Chart         IMGN Immunogen Inc 51 New $8.82 $8,945,000 999,496 0.1% 8,945,000 999,496 1.167    Drug Manufacturers - ...
   (OSIR)1 Year Chart         OSIR Osiris Therapeutics, Inc. 52 - $18.36 $8,776,000 499,193 0.09% 611,000 -11,413 1.476    Biotechnology
   (PRQR)1 Year Chart         PRQR ProQR Therapeutics N.V. 53 - $19.69 $8,752,000 400,000 0.09% 84,000 0 1.714    N/A
   (ARWR)1 Year Chart         ARWR Arrowhead Research Corp 54 - $6.16 $8,728,000 1,290,187 0.09% -355,000 59,385 2.487    Business Services
   (SNSS)1 Year Chart         SNSS Sunesis Pharmaceuticals Inc 55 - $2.43 $7,840,000 3,200,000 0.08% -320,000 0 5.928    Biotechnology
   (LJPC)1 Year Chart         LJPC La Jolla Pharmaceutical Co 56 - $19.54 $7,540,000 412,008 0.08% -239,000 -9,623 2.707    Biotechnology
   (CNCE)1 Year Chart         CNCE Concert Pharmaceuticals, Inc. 57 - $14.29 $7,511,000 495,908 0.08% 779,000 -9,510 2.77    N/A
   (CLDN)1 Year Chart         CLDN Celladon Corp 58 - $2.16 $6,947,000 366,806 0.07% -377,000 -8,194 1.983    N/A
   (KPTI)1 Year Chart         KPTI Karyopharm Therapeutics Inc. 59 - $26.27 $6,642,000 216,990 0.07% 3,120,000 122,895 0.729    N/A
   (JUNO)1 Year Chart         JUNO Juno Therapeutics, Inc. 60 - $46.34 $6,066,000 100,000 0.06% 844,000 0 0.111    N/A
   (FMI)1 Year Chart         FMI Foundation Medicine, Inc. 61 - $35.31 $5,978,000 124,255 0.06% 3,175,000 -1,892 0.455    N/A
   (RXDX)1 Year Chart         RXDX Ignyta, Inc. 62 - $9.18 $5,681,000 571,000 0.06% 1,770,000 0 2.916    N/A
   (LGND)1 Year Chart         LGND Ligand Pharmaceuticals Inc 63 - $89.23 $5,659,000 73,386 0.06% 1,753,000 -14 0.327    Drug Manufacturers - ...
   (TTHI)1 Year Chart         TTHI Transition Therapeutics 64 New $6.92 $5,254,000 769,230 0.06% 5,254,000 769,230 2.591    Biotechnology
   (AMRN)1 Year Chart         AMRN Amarin Corp Plc 65 New $1.90 $5,161,000 2,205,710 0.06% 5,161,000 2,205,710 1.278    Drug Manufacturers - ...
   (STML)1 Year Chart         STML Stemline Therapeutics Inc 66 - $13.25 $4,826,000 333,497 0.05% -952,000 -5,174 2.588    N/A
   (CYTR)1 Year Chart         CYTR Cytrx Corp 67 - $4.15 $4,448,000 1,319,989 0.05% 749,000 -30,011 4.331    Biotechnology
   (EPZM)1 Year Chart         EPZM Epizyme, Inc. 68 - $19.00 $4,366,000 232,481 0.05% 555,000 30,518 0.692    Biotechnology
   (CMRX)1 Year Chart         CMRX Chimerix Inc 69 - $42.24 $4,342,000 115,216 0.05% -2,599,000 -57,198 0.316    Biotechnology
   (INFI)1 Year Chart         INFI Infinity Pharmaceuticals Inc 70 - $12.87 $4,264,000 305,037 0.05% -1,006,000 -6,988 0.634    Biotechnology
   (DSCO)1 Year Chart         DSCO Discovery Laboratories Inc 71 - $0.83 $4,248,000 3,569,643 0.05% 12,000 -82,474 6.515    Biotechnology
   (RCPT)1 Year Chart         RCPT Receptos, Inc. 72 - $160.11 $3,941,000 23,900 0.04% 1,013,000 0 0.076    N/A
   (SAGE)1 Year Chart         SAGE Sage Therapeutics, Inc. 73 - $0.00 $3,767,000 75,000 0.04% 1,022,000 0 0.291    N/A
   (ZFGN)1 Year Chart         ZFGN Zafgen, Inc. 74 New $30.45 $3,753,000 94,745 0.04% 3,753,000 94,745 0.417    N/A
   (ISIS)1 Year Chart         ISIS Isis Pharmaceuticals Inc 75 - $67.17 $3,638,000 57,140 0.04% -2,308,000 -39,163 0.049    Drug Manufacturers - ...
   (LPCN)1 Year Chart         LPCN Lipocine Inc 76 - $7.09 $3,375,000 489,175 0.04% 745,000 -10,825 3.83    Conglomerates
   (NDRM)1 Year Chart         NDRM Neuroderm Ltd 77 - $13.97 $3,355,000 250,000 0.04% -155,000 0 2.778    N/A
   (ASMB)1 Year Chart         ASMB Assembly Biosciences Inc 78 New $14.41 $3,310,000 250,000 0.04% 3,310,000 250,000 1.069    Drug Manufacturers - ...
   (TKMR)1 Year Chart         TKMR Tekmira Pharmaceuticals Corp 79 - $13.89 $3,153,000 180,582 0.03% -4,182,000 -303,574 1.241    N/A
   (ZGNX)1 Year Chart         ZGNX Zogenix, Inc. 80 - $1.40 $3,149,000 2,298,466 0.03% -71,000 -51,934 2.132    Drug Manufacturers - ...
   (AUPH)1 Year Chart         AUPH Aurinia Pharmaceuticals Inc 81 - $3.61 $3,118,000 711,499 0.03% 519,000 -16,170 1.172    N/A
   (IRWD)1 Year Chart         IRWD Ironwood Pharmaceuticals Inc 82 - $13.78 $2,707,000 169,163 0.03% -2,596,000 -176,997 0.121    Medical Laboratories ...
   (BDSI)1 Year Chart         BDSI Biodelivery Sciences Intern... 83 - $8.49 $2,686,000 255,866 0.03% 162,000 45,845 0.67    Drug Manufacturers - ...
   (AFMD)1 Year Chart         AFMD Affimed Nv 84 - $9.10 $2,520,000 400,000 0.03% 40,000 0 1.668    N/A
   (ASPX)1 Year Chart         ASPX Auspex Pharmaceuticals, Inc. 85 New $100.93 $2,507,000 25,000 0.03% 2,507,000 25,000 0.11    N/A
   (ITCI)1 Year Chart         ITCI Intra Cellular Therapies Inc 86 New $24.74 $2,487,000 104,166 0.03% 2,487,000 104,166 0.356    N/A
   (ENTA)1 Year Chart         ENTA Enanta Pharmaceuticals Inc 87 - $40.53 $2,307,000 75,357 0.02% -1,525,000 0 0.419    Biotechnology
   (MSTX)1 Year Chart         MSTX Mast Therapeutics Inc 88 - $0.51 $2,283,000 4,707,464 0.02% -391,000 -66,970 4.583    Biotechnology
   (VTAE)1 Year Chart         VTAE Vitae Pharmaceuticals, Inc 89 New $0.00 $2,197,000 187,597 0.02% 2,197,000 187,597 0.876    N/A
   (ACHN)1 Year Chart         ACHN Achillion Pharmaceuticals Inc 90 - $9.11 $2,112,000 214,237 0.02% -3,258,000 -224,100 0.222    Biotechnology
   (PTN)1 Year Chart         PTN Palatin Technologies Inc 91 - $0.90 $2,091,000 2,050,000 0.02% 594,000 0 5.231    Diagnostic Substances
   (ZIOP)1 Year Chart         ZIOP Ziopharm Oncology Inc 92 - $9.44 $2,038,000 189,259 0.02% 1,056,000 -4,381 0.226    Biotechnology
   (PRTO)1 Year Chart         PRTO Proteon Therapeutics Inc 93 - $17.15 $2,011,000 172,917 0.02% 213,000 0 1.051    N/A
   (BOTA)1 Year Chart         BOTA Nabi Biopharmaceuticals 94 - $2.21 $1,985,000 863,184 0.02% -494,000 -243,726 3.043    Biotechnology
   (MRNS)1 Year Chart         MRNS Marinus Pharmaceuticals Inc 95 - $0.00 $1,798,000 200,000 0.02% -363,000 -4,476 1.428    N/A
   (OPHT)1 Year Chart         OPHT Ophthotech Corp. 96 - $51.89 $1,659,000 35,649 0.02% 9,000 -1,127 0.114    N/A
   (MDWD)1 Year Chart         MDWD MediWound Ltd. 97 - $5.28 $1,629,000 225,000 0.02% 130,000 0 1.479    N/A
   (DERM)1 Year Chart         DERM Dermira, Inc. 98 - $15.01 $1,535,000 100,000 0.02% -276,000 0 0.407    N/A
   (OSUR)1 Year Chart         OSUR Orasure Technologies Inc 99 - $6.42 $1,500,000 229,397 0.02% -879,000 -5,267 0.413    Medical Instruments &...
   (ALDX)1 Year Chart         ALDX Aldeyra Therapeutics, Inc. 100 New $7.22 $1,446,000 142,000 0.02% 1,446,000 142,000 2.276    N/A

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