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  Name: BAKER BROS ADVISORS LLC
  City: NEW YORK
  State: NY
  Zip: 10021
   
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Portfolio Summary View Filing
  Filing Report Date : 2013-12-31
  Total Value : $5,372,160,000
  Total Value Change : $-274,548,000
  Securities Held Change : 9
   
All Securities Held : 83
  New Positions : 23
  Closed Positions : 6
  Increased Positions : 12
  Unchanged Positions : 34
  Decreased Positions : 14
 
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Holdings Found : 85     View All Holdings Currently Viewing:  ALL     Page 1 of 1
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Ticker Company Name Position
Rank
New/Closed
Postion
Last
Close
    Value Shares Held
% of
Portfolio
Value
Change
Change In
Shares Held
   % of Company    Industry
   (PCYC)1 Year Chart         PCYC Pharmacyclics Inc 1 - $90.04 $922,319,000 8,719,218 17.17% -323,433,000 -290,993 12.838    Drug Manufacturers - ...
   (SGEN)1 Year Chart         SGEN Seattle Genetics Inc 2 - $38.57 $827,156,000 20,735,926 15.4% -19,769,000 1,412,979 17.109    Biotechnology
   (INCY)1 Year Chart         INCY Incyte Corp 3 - $43.98 $749,859,000 14,810,559 13.96% 184,836,000 0 9.676    Biotechnology
   (GEVA)1 Year Chart         GEVA Synageva BioPharma Corp 4 - $79.38 $664,880,000 10,273,182 12.38% 13,642,000 0 33.42    Biotechnology
   (ACAD)1 Year Chart         ACAD Acadia Pharmaceuticals Inc 5 - $19.28 $498,679,000 19,955,126 9.28% -49,488,000 0 25.195    Biotechnology
   (GHDX)1 Year Chart         GHDX Genomic Health Inc 6 - $26.83 $399,560,000 13,650,835 7.44% -17,882,000 0 46.287    Biotechnology
   (XOMA)1 Year Chart         XOMA XOMA Corporation 7 - $4.32 $155,008,000 23,032,372 2.89% 51,593,000 0 24.745    Biotechnology
   (BMRN)1 Year Chart         BMRN Biomarin Pharmaceutical Inc 8 - $61.37 $136,571,000 1,941,304 2.54% 80,039,000 1,157,993 1.397    Drug Manufacturers - ...
   (HALO)1 Year Chart         HALO Halozyme Therapeutics Inc 9 - $7.55 $94,392,000 6,297,026 1.76% 16,918,000 -720,582 6.078    Biotechnology
   (VNDA)1 Year Chart         VNDA Vanda Pharmaceuticals Inc. 10 - $13.85 $59,459,000 4,791,179 1.11% 6,996,000 0 14.436    Biotechnology
   (CERS)1 Year Chart         CERS Cerus Corp 11 - $4.44 $54,537,000 8,455,306 1.02% -2,283,000 0 12    Biotechnology
   (BCRX)1 Year Chart         BCRX Biocryst Pharmaceuticals Inc 12 - $8.34 $50,920,000 6,699,979 0.95% 2,144,000 0 14.839    Biotechnology
   (RPRX)1 Year Chart         RPRX Repros Therapeutics 13 - $15.70 $50,849,000 2,778,654 0.95% -23,619,000 0 12.079    Biotechnology
   (QCOR)1 Year Chart         QCOR Questcor Pharmaceuticals Inc 14 - $78.46 $42,246,000 775,864 0.79% 10,587,000 230,018 1.222    Rental & Leasing Serv...
   (ANAC)1 Year Chart         ANAC Anacor Pharmaceuticals Inc 15 New $15.37 $41,950,000 2,500,000 0.78% 41,950,000 2,500,000 6.164    Biotechnology
   (GILD)1 Year Chart         GILD Gilead Sciences Inc 16 - $69.28 $41,764,000 556,108 0.78% -36,559,000 -689,692 0.036    Biotechnology
   (AEGR)1 Year Chart         AEGR Aegerion Pharmaceuticals, Inc. 17 - $43.52 $35,480,000 500,000 0.66% -34,859,000 -320,275 1.735    Drug Manufacturers - ...
   (ARWR)1 Year Chart         ARWR Arrowhead Research Corp 18 - $12.39 $33,527,000 3,090,000 0.62% 15,660,000 -50,000 9.797    Business Services
   (CLVS)1 Year Chart         CLVS Clovis Oncology, Inc. 19 - $56.22 $31,988,000 530,738 0.6% 13,642,000 228,994 1.759    Biotechnology
   (DSCI)1 Year Chart         DSCI Derma Sciences Inc 20 - $9.66 $27,687,000 2,558,857 0.52% -3,992,000 0 14.825    Drug Manufacturers - ...
   (CHTP)1 Year Chart         CHTP Chelsea Therapeutics Intern... 21 - $4.76 $25,700,000 5,794,753 0.48% 8,374,000 0 9.369    Biotechnology
   (MDVN)1 Year Chart         MDVN Medivation Inc 22 - $58.84 $25,421,000 398,331 0.47% 1,545,000 0 0.536    Biotechnology
   (ICPT)1 Year Chart         ICPT Intercept Inc 23 - $237.51 $24,775,000 362,847 0.46% -272,000 0 2.16    N/A
   (PGNX)1 Year Chart         PGNX Progenics Pharmaceuticals Inc 24 - $3.56 $22,386,000 4,200,000 0.42% 1,302,000 0 8.229    Drug Manufacturers - ...
   (AVNR)1 Year Chart         AVNR Avanir Pharmaceuticals 25 - $3.42 $18,240,000 5,428,591 0.34% -493,000 1,000,000 4.371    Drug Manufacturers - ...
   (DYAX)1 Year Chart         DYAX DYAX Corp 26 New $6.80 $15,270,000 2,026,537 0.28% 15,270,000 2,026,537 1.674    Biotechnology
   (IDRA)1 Year Chart         IDRA Idera Pharmaceuticals Inc 28 - $2.94 $14,685,000 3,171,765 0.27% 4,480,000 -2,693,235 0    Biotechnology
   (SGYP)1 Year Chart         SGYP Synergy Pharmaceuticals Inc... 27 - $4.25 $14,685,000 2,608,271 0.27% 2,765,000 0 15.537    N/A
   (INSM)1 Year Chart         INSM Insmed Inc 29 - $12.53 $13,538,000 796,378 0.25% -1,226,000 -149,425 2.036    Biotechnology
   (STML)1 Year Chart         STML Stemline Therapeutics Inc 30 - $15.80 $13,231,000 675,042 0.25% -23,024,000 -125,358 5.789    N/A
   (KYTH)1 Year Chart         KYTH Kythera Biopharmaceuticals Inc 31 - $36.28 $11,698,000 313,191 0.22% -383,000 48,191 1.68    Drug Manufacturers - ...
   (ISIS)1 Year Chart         ISIS Isis Pharmaceuticals Inc 32 - $34.57 $9,842,000 247,036 0.18% 568,000 0 0.248    Drug Manufacturers - ...
   (ZGNX)1 Year Chart         ZGNX Zogenix, Inc. 33 - $2.82 $9,463,000 2,751,000 0.18% 5,759,000 750,000 2.733    Drug Manufacturers - ...
   (PRTA)1 Year Chart         PRTA Prothena Corp Plc 34 - $28.07 $8,935,000 336,918 0.17% 1,457,000 -32,732 1.906    N/A
   (THLD)1 Year Chart         THLD Threshold Pharmaceuticals Inc 35 - $4.02 $8,651,000 1,852,399 0.16% 37,000 0 3.796    Diagnostic Substances
   (TGTX)1 Year Chart         TGTX TG Therapeutics Inc 36 - $5.13 $8,579,000 2,199,656 0.16% 5,555,000 1,599,656 6.566    Drug Manufacturers - ...
   (QLTI)1 Year Chart         QLTI QLT Inc 37 - $5.81 $8,555,000 1,535,863 0.16% 1,444,000 0 3.075    Diagnostic Substances
   (DSCO)1 Year Chart         DSCO Discovery Laboratories Inc 38 - $1.96 $8,367,000 3,718,617 0.16% 5,391,000 2,200,000 6.787    Biotechnology
   (ARRY)1 Year Chart         ARRY Array Biopharma Inc 39 - $3.84 $7,515,000 1,500,000 0.14% -1,815,000 0 1.282    Medical Laboratories ...
   (AMBI)1 Year Chart         AMBI Ambit Biosciences Corp 40 New $6.41 $7,210,000 747,954 0.13% 7,210,000 747,954 0    Biotechnology
   (OMER)1 Year Chart         OMER Omeros Corp 41 - $11.33 $6,869,000 608,404 0.13% 937,000 0 2.74    Drug Manufacturers - ...
   (NVAX)1 Year Chart         NVAX Novavax Inc 42 - $4.05 $6,589,000 1,286,913 0.12% 1,181,000 -430,000 0.617    Biotechnology
   (IRWD)1 Year Chart         IRWD Ironwood Pharmaceuticals Inc 43 - $10.61 $6,341,000 546,160 0.12% 881,000 85,000 0.505    Medical Laboratories ...
   (OSIR)1 Year Chart         OSIR Osiris Therapeutics, Inc. 44 - $12.69 $6,035,000 375,282 0.11% -210,000 0 1.143    Biotechnology
   (XNPT)1 Year Chart         XNPT Xenoport Inc 45 - $4.18 $5,946,000 1,034,112 0.11% 72,000 0 2.407    Drug Related Products
   (SGMO)1 Year Chart         SGMO Sangamo Biosciences Inc 46 - $14.26 $5,894,000 424,308 0.11% 4,040,000 247,601 0.809    Biotechnology
   (PTLA)1 Year Chart         PTLA Portola Pharmaceuticals Inc 47 New $22.96 $5,779,000 224,434 0.11% 5,779,000 224,434 0    Biotechnology
   (AERI)1 Year Chart         AERI Aerie Pharmaceuticals Inc 48 New $14.91 $5,388,000 300,000 0.1% 5,388,000 300,000 1.289    Drug Manufacturers - ...
   (BDSI)1 Year Chart         BDSI Biodelivery Sciences Intern... 49 - $7.40 $4,983,000 846,005 0.09% 389,000 0 2.862    Drug Manufacturers - ...
   (AGIO)1 Year Chart         AGIO Agios Pharmaceuticals Inc 50 New $39.21 $4,928,000 205,750 0.09% 4,928,000 205,750 0.66    N/A
   (BOTA)1 Year Chart         BOTA Nabi Biopharmaceuticals 51 New $5.16 $4,735,000 1,130,113 0.09% 4,735,000 1,130,113 2.635    Biotechnology
   (VTUS)1 Year Chart         VTUS Ventrus Biosciences Inc 52 - $1.07 $4,645,000 1,215,840 0.09% 1,131,000 0 6.202    Drug Manufacturers - ...
   (EPZM)1 Year Chart         EPZM Epizyme, Inc. 53 New $19.98 $4,576,000 220,000 0.09% 4,576,000 220,000 0.774    Biotechnology
   (TKMR)1 Year Chart         TKMR Tekmira Pharmaceuticals Corp 54 New $13.98 $3,985,000 500,000 0.07% 3,985,000 500,000 4.121    N/A
   (LGND)1 Year Chart         LGND Ligand Pharmaceuticals Inc 55 - $62.90 $3,861,000 73,400 0.07% 684,000 0 0.375    Drug Manufacturers - ...
   (OPHT)1 Year Chart         OPHT Ophthotech Corp. 56 New $31.83 $3,333,000 103,040 0.06% 3,333,000 103,040 0    N/A
   (ENTA)1 Year Chart         ENTA Enanta Pharmaceuticals Inc 57 New $33.13 $2,976,000 109,097 0.06% 2,976,000 109,097 0    Biotechnology
   (RCPT)1 Year Chart         RCPT Receptos, Inc. 58 New $35.03 $2,899,000 100,000 0.05% 2,899,000 100,000 0    N/A
   (MGNX)1 Year Chart         MGNX Macrogenics Inc 59 New $20.21 $2,743,000 100,000 0.05% 2,743,000 100,000 0.397    Biotechnology
   (SNTA)1 Year Chart         SNTA Synta Pharmaceuticals Corp 60 - $4.09 $2,620,000 500,000 0.05% -535,000 0 0.724    Diagnostic Substances
   (PBYI)1 Year Chart         PBYI Puma Biotechnology Inc 61 - $72.85 $2,588,000 25,000 0.05% -2,778,000 -75,000 0.087    N/A
   (BLUE)1 Year Chart         BLUE Bluebird Bio, Inc. 62 New $19.53 $2,401,000 114,461 0.04% 2,401,000 114,461 0.484    Biotechnology
   (UTHR)1 Year Chart         UTHR United Therapeutics Corp 63 - $98.22 $2,262,000 20,000 0.04% -2,152,000 -35,984 0.037    Drug Manufacturers - ...
   (ITMN)1 Year Chart         ITMN InterMune Inc 64 New $28.31 $2,210,000 150,000 0.04% 2,210,000 150,000 0.184    Drug Manufacturers - ...
   (GERN)1 Year Chart         GERN Geron Corporation 65 - $1.97 $1,908,000 402,629 0.04% -1,442,000 -597,371 0.306    Drug Manufacturers - ...
   (OSUR)1 Year Chart         OSUR Orasure Technologies Inc 66 - $6.67 $1,531,000 243,467 0.03% 68,000 0 0.519    Medical Instruments &...
   (ACHN)1 Year Chart         ACHN Achillion Pharmaceuticals Inc 67 - $2.79 $1,510,000 455,000 0.03% 136,000 0 0.471    Biotechnology
   (RIGL)1 Year Chart         RIGL Rigel Pharmaceuticals Inc 68 - $3.20 $1,425,000 500,000 0.03% -365,000 0 0.575    Drug Manufacturers - ...
   (KPTI)1 Year Chart         KPTI Karyopharm Therapeutics Inc. 69 New $32.40 $1,406,000 61,330 0.03% 1,406,000 61,330 0.206    N/A
   (FOLD)1 Year Chart         FOLD Amicus Therapeutics Inc 70 - $1.82 $1,210,000 515,072 0.02% 15,000 0 1.489    Biotechnology
   (XLRN)1 Year Chart         XLRN Acceleron Pharma Inc 71 New $37.80 $1,188,000 30,000 0.02% 1,188,000 30,000 0    N/A
   (ZIOP)1 Year Chart         ZIOP Ziopharm Oncology Inc 72 - $3.38 $1,103,000 254,199 0.02% 101,000 0 0.372    Biotechnology
   (TSRO)1 Year Chart         TSRO Tesaro, Inc. 73 - $25.56 $882,000 31,218 0.02% -327,000 0 0.115    Biotechnology
   (GALT)1 Year Chart         GALT Galectin Therapeutics Inc 74 New $10.28 $813,000 100,600 0.02% 813,000 100,600 0.64    Drugs - Generic
   (FMI)1 Year Chart         FMI Foundation Medicine, Inc. 75 New $27.18 $476,000 20,000 0.01% 476,000 20,000 0.071    N/A
   (FPRX)1 Year Chart         FPRX Five Prime Therapeutics Inc 76 New $14.64 $333,000 19,823 0.01% 333,000 19,823 0.1    Biotechnology
   (SLXP)1 Year Chart         SLXP Salix Pharmaceuticals Ltd 77 - $100.66 $326,000 3,621 0.01% 84,000 0 0.006    Drug Related Products
   (CCXI)1 Year Chart         CCXI Chemocentryx, Inc. 78 - $5.30 $290,000 50,000 0.01% -822,000 -150,000 0.138    Biotechnology
   (CYCCP)1 Year Chart         CYCCP Cyclacel Pharmaceuticals, Inc 79 - $8.63 $193,000 20,979 0% 16,000 0 0.13    Biotechnology
   (INFI)1 Year Chart         INFI Infinity Pharmaceuticals Inc 83 Closed $10.60 $0 0 0% -10,230,000 -586,936 0    Biotechnology
   (MEIP)1 Year Chart         MEIP MEI Pharma Inc 82 Closed $8.65 $0 0 0% -3,885,000 -345,317 0    Drug Manufacturers - ...
   (ARIA)1 Year Chart         ARIA Ariad Pharmaceuticals Inc 81 Closed $7.10 $0 0 0% -24,540,000 -1,333,703 0    Biotechnology
   (VPHM)1 Year Chart         VPHM Viropharma Inc 85 Closed $49.96 $0 0 0% -219,551,000 -5,592,239 0    Biotechnology
   (TRGT)1 Year Chart         TRGT Targacept Inc 80 Closed $4.08 $0 0 0% -10,984,000 -2,068,186 0    Biotechnology
   (CBST)1 Year Chart         CBST Cubist Pharmaceuticals Inc 84 Closed $63.93 $0 0 0% -318,000 -5,000 0    Drug Manufacturers - ...

      85 Records Found
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