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  Name: BAKER BROS ADVISORS LLC
  City: NEW YORK
  State: NY
  Zip: 10021
   
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Portfolio Summary View Filing
  Filing Report Date : 2014-12-31
  Total Value : $7,735,680,000
  Total Value Change : $1,872,115,000
  Securities Held Change : 13
   
All Securities Held : 110
  New Positions : 13
  Closed Positions : 1
  Increased Positions : 16
  Unchanged Positions : 69
  Decreased Positions : 12
 
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Holdings Found : 100     View All Holdings Currently Viewing:  ALL     Page 1 of 1
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Ticker Company Name Position
Rank
New/Closed
Postion
Last
Close
    Value Shares Held
% of
Portfolio
Value
Change
Change In
Shares Held
   % of Company    Industry
   (PCYC)1 Year Chart         PCYC Pharmacyclics Inc 1 - $254.22 $1,116,140,000 9,129,231 14.43% -17,834,000 -527,368 12.407    Drug Manufacturers - ...
   (INCY)1 Year Chart         INCY Incyte Corp 2 - $91.97 $1,085,359,000 14,845,559 14.03% 357,184,000 0 9.228    Biotechnology
   (GEVA)1 Year Chart         GEVA Synageva BioPharma Corp 3 - $101.24 $989,182,000 10,660,432 12.79% 255,957,000 0 31.354    Biotechnology
   (SGEN)1 Year Chart         SGEN Seattle Genetics Inc 4 - $35.60 $895,197,000 27,861,720 11.57% 59,549,000 5,385,991 22.469    Biotechnology
   (AVNR)1 Year Chart         AVNR Avanir Pharmaceuticals 5 - $16.94 $652,807,000 38,513,713 8.44% 402,789,000 17,539,036 25.293    Drug Manufacturers - ...
   (ACAD)1 Year Chart         ACAD Acadia Pharmaceuticals Inc 6 - $39.26 $650,286,000 20,481,442 8.41% 143,165,000 0 20.481    Biotechnology
   (GHDX)1 Year Chart         GHDX Genomic Health Inc 7 - $32.33 $436,592,000 13,656,318 5.64% 50,002,000 700 44.428    Biotechnology
   (BMRN)1 Year Chart         BMRN Biomarin Pharmaceutical Inc 8 - $113.50 $335,741,000 3,713,950 4.34% 164,688,000 1,343,486 2.509    Drug Manufacturers - ...
   (ANAC)1 Year Chart         ANAC Anacor Pharmaceuticals Inc 9 - $46.82 $135,602,000 4,204,702 1.75% 32,713,000 0 10.32    Biotechnology
   (BCRX)1 Year Chart         BCRX Biocryst Pharmaceuticals Inc 10 - $10.23 $130,278,000 10,713,686 1.68% 25,498,000 0 18.131    Biotechnology
   (BLCM)1 Year Chart         BLCM Bellicum Pharmaceuticals, Inc 11 New $24.35 $98,697,000 4,283,732 1.28% 98,697,000 4,283,732 16.572    N/A
   (DYAX)1 Year Chart         DYAX DYAX Corp 12 - $15.69 $86,579,000 6,157,789 1.12% 24,262,000 0 4.495    Biotechnology
   (CERS)1 Year Chart         CERS Cerus Corp 13 - $4.45 $73,025,000 11,702,727 0.94% 25,145,000 -237,451 16.61    Biotechnology
   (SLXP)1 Year Chart         SLXP Salix Pharmaceuticals Ltd 14 - $157.44 $73,024,000 635,321 0.94% 71,677,000 626,700 0.993    Drug Related Products
   (VNDA)1 Year Chart         VNDA Vanda Pharmaceuticals Inc. 15 - $10.71 $64,041,000 4,472,153 0.83% 18,658,000 100,000 8.91    Biotechnology
   (XOMA)1 Year Chart         XOMA XOMA Corporation 16 - $3.83 $60,757,000 16,924,013 0.79% -36,374,000 -6,147,459 18.257    Biotechnology
   (XNPT)1 Year Chart         XNPT Xenoport Inc 17 - $7.13 $60,545,000 6,903,628 0.78% 23,876,000 87,851 11.155    Drug Related Products
   (VSAR)1 Year Chart         VSAR Versartis, Inc. 18 - $21.43 $51,225,000 2,281,744 0.66% 27,562,000 1,035,655 9.81    N/A
   (MRTX)1 Year Chart         MRTX Mirati Therapeutics, Inc. 19 - $26.65 $44,079,000 2,380,074 0.57% 2,404,000 0 17.656    Biotechnology
   (DBVT)1 Year Chart         DBVT DBV Technologies SA New $21.19 $41,201,000 1,519,229 0.53% 41,201,000 1,519,229 4.118    N/A
   (PGNX)1 Year Chart         PGNX Progenics Pharmaceuticals Inc 20 - $6.82 $33,640,000 4,449,797 0.43% 10,546,000 0 7.316    Drug Manufacturers - ...
   (DSCI)1 Year Chart         DSCI Derma Sciences Inc 21 - $8.19 $32,931,000 3,537,137 0.43% 3,467,000 0 14.047    Drug Manufacturers - ...
   (TGTX)1 Year Chart         TGTX TG Therapeutics Inc 22 - $15.59 $32,477,000 2,050,313 0.42% 10,600,000 0 6.139    Drug Manufacturers - ...
   (ACOR)1 Year Chart         ACOR Acorda Therapeutics Inc 23 - $35.30 $30,879,000 755,534 0.4% 5,354,000 2,143 1.799    Biotechnology
   (HALO)1 Year Chart         HALO Halozyme Therapeutics Inc 24 - $15.39 $26,790,000 2,776,143 0.35% 1,527,000 0 2.436    Biotechnology
   (HRTX)1 Year Chart         HRTX Heron Therapeutics Inc 25 - $15.47 $26,234,000 2,607,784 0.34% 4,511,000 0 1.304    Synthetics
   (GILD)1 Year Chart         GILD Gilead Sciences Inc 26 - $103.42 $24,141,000 256,108 0.31% -3,122,000 0 0.017    Biotechnology
   (CPRX)1 Year Chart         CPRX Catalyst Pharmaceutical Par... 27 - $4.04 $19,945,000 6,715,462 0.26% -2,350,000 0 9.999    Drugs - Generic
   (RPRX)1 Year Chart         RPRX Repros Therapeutics 28 - $9.85 $19,940,000 2,000,000 0.26% -7,569,000 -778,654 8.692    Biotechnology
   (AGIO)1 Year Chart         AGIO Agios Pharmaceuticals Inc 29 - $107.44 $18,307,000 163,393 0.24% 7,884,000 -6,500 0.526    N/A
   (INSM)1 Year Chart         INSM Insmed Inc 30 - $20.33 $17,138,000 1,107,850 0.22% 2,681,000 0 2.231    Biotechnology
   (OMER)1 Year Chart         OMER Omeros Corp 31 - $26.35 $16,060,000 648,101 0.21% 5,772,000 -160,674 2.171    Drug Manufacturers - ...
   (SGMO)1 Year Chart         SGMO Sangamo Biosciences Inc 32 - $18.06 $14,531,000 955,332 0.19% 5,204,000 90,476 1.555    Biotechnology
   (BLUE)1 Year Chart         BLUE Bluebird Bio, Inc. 33 - $112.23 $13,758,000 150,000 0.18% 8,376,000 0 0.461    Biotechnology
   (NBIX)1 Year Chart         NBIX Neurocrine Biosciences Inc 34 - $40.92 $12,390,000 554,590 0.16% 3,700,000 0 0.73    Biotechnology
   (CLVS)1 Year Chart         CLVS Clovis Oncology, Inc. 35 - $79.66 $11,347,000 202,630 0.15% 11,347,000 202,630 0.672    Biotechnology
   (MGNX)1 Year Chart         MGNX Macrogenics Inc 36 - $35.58 $10,938,000 311,891 0.14% 4,419,000 0 1.238    Biotechnology
   (KYTH)1 Year Chart         KYTH Kythera Biopharmaceuticals Inc 37 - $50.00 $9,927,000 286,255 0.13% -270,000 -25,000 1.525    Drug Manufacturers - ...
   (XNCR)1 Year Chart         XNCR Xencor Inc 38 - $16.00 $9,486,000 591,371 0.12% 4,437,000 49,008 1.886    Biotechnology
   (ARWR)1 Year Chart         ARWR Arrowhead Research Corp 39 - $7.94 $9,083,000 1,230,802 0.12% -9,096,000 0 2.373    Business Services
   (AQXP)1 Year Chart         AQXP Aquinox Pharmaceuticals, Inc 40 - $10.06 $9,078,000 1,210,350 0.12% 1,007,000 -1,501 12.055    N/A
   (AERI)1 Year Chart         AERI Aerie Pharmaceuticals Inc 41 - $28.92 $8,738,000 299,356 0.11% 2,544,000 0 1.286    Drug Manufacturers - ...
   (PRQR)1 Year Chart         PRQR ProQR Therapeutics N.V. 42 - $21.37 $8,668,000 400,000 0.11% 1,792,000 0 1.714    N/A
   (OSIR)1 Year Chart         OSIR Osiris Therapeutics, Inc. 43 - $16.94 $8,165,000 510,606 0.11% 1,736,000 0 1.51    Biotechnology
   (SNSS)1 Year Chart         SNSS Sunesis Pharmaceuticals Inc 44 New $2.29 $8,160,000 3,200,000 0.11% 8,160,000 3,200,000 5.928    Biotechnology
   (LJPC)1 Year Chart         LJPC La Jolla Pharmaceutical Co 45 - $21.32 $7,779,000 421,631 0.1% 3,727,000 0 2.77    Biotechnology
   (TKMR)1 Year Chart         TKMR Tekmira Pharmaceuticals Corp 46 - $19.69 $7,335,000 484,156 0.09% -2,900,000 0 3.327    N/A
   (CLDN)1 Year Chart         CLDN Celladon Corp 47 - $21.46 $7,324,000 375,000 0.09% 3,401,000 0 2.027    N/A
   (NVAX)1 Year Chart         NVAX Novavax Inc 48 - $9.31 $7,255,000 1,223,362 0.09% 2,154,000 0 0.587    Biotechnology
   (IDRA)1 Year Chart         IDRA Idera Pharmaceuticals Inc 49 - $4.89 $7,181,000 1,628,172 0.09% 3,473,000 8,914 2.598    Biotechnology
   (FOMX)1 Year Chart         FOMX Foamix Pharmaceuticals Ltd 50 - $9.25 $7,161,000 1,021,600 0.09% 1,593,000 0 4.756    N/A
   (CMRX)1 Year Chart         CMRX Chimerix Inc 51 New $40.79 $6,941,000 172,414 0.09% 6,941,000 172,414 0.473    Biotechnology
   (THLD)1 Year Chart         THLD Threshold Pharmaceuticals Inc 52 - $4.56 $6,855,000 2,155,516 0.09% -936,000 -2,625 3.643    Diagnostic Substances
   (ARRY)1 Year Chart         ARRY Array Biopharma Inc 53 - $8.24 $6,782,000 1,433,797 0.09% 1,663,000 0 1.149    Medical Laboratories ...
   (CNCE)1 Year Chart         CNCE Concert Pharmaceuticals, Inc. 54 - $14.46 $6,732,000 505,418 0.09% 1,039,000 53,922 2.824    N/A
   (RARE)1 Year Chart         RARE Ultragenyx Pharmaceutical Inc 55 - $59.22 $6,582,000 150,000 0.09% -1,908,000 0 0.499    Restaurants
   (QLTI)1 Year Chart         QLTI QLT Inc 56 - $4.05 $6,159,000 1,535,863 0.08% -783,000 0 3.007    Diagnostic Substances
   (ISIS)1 Year Chart         ISIS Isis Pharmaceuticals Inc 57 - $71.76 $5,946,000 96,303 0.08% 2,207,000 0 0.083    Drug Manufacturers - ...
   (STML)1 Year Chart         STML Stemline Therapeutics Inc 58 - $15.90 $5,778,000 338,671 0.07% 1,558,000 0 2.628    N/A
   (ACHN)1 Year Chart         ACHN Achillion Pharmaceuticals Inc 59 - $10.99 $5,370,000 438,337 0.07% 995,000 0 0.453    Biotechnology
   (IRWD)1 Year Chart         IRWD Ironwood Pharmaceuticals Inc 60 - $15.77 $5,303,000 346,160 0.07% 818,000 0 0.247    Medical Laboratories ...
   (INFI)1 Year Chart         INFI Infinity Pharmaceuticals Inc 61 - $16.51 $5,270,000 312,025 0.07% 1,083,000 0 0.649    Biotechnology
   (JUNO)1 Year Chart         JUNO Juno Therapeutics, Inc. 62 New $52.03 $5,222,000 100,000 0.07% 5,222,000 100,000 1.111    N/A
   (MNK)1 Year Chart         MNK Mallinckrodt Plc 63 - $121.70 $4,621,000 46,666 0.06% -13,576,000 -155,190 0.039    Drugs - Generic
   (ALDR)1 Year Chart         ALDR Alder Biopharmaceuticals Inc 64 - $25.69 $4,461,000 153,350 0.06% 2,517,000 0 0.498    N/A
   (DSCO)1 Year Chart         DSCO Discovery Laboratories Inc 65 - $1.76 $4,236,000 3,652,117 0.05% -2,484,000 0 6.666    Biotechnology
   (FOLD)1 Year Chart         FOLD Amicus Therapeutics Inc 66 - $8.65 $4,008,000 481,697 0.05% 1,142,000 0 0.605    Biotechnology
   (RXDX)1 Year Chart         RXDX Ignyta, Inc. 67 - $7.85 $3,911,000 571,000 0.05% -691,000 0 2.916    N/A
   (LGND)1 Year Chart         LGND Ligand Pharmaceuticals Inc 68 - $68.96 $3,906,000 73,400 0.05% 457,000 0 0.327    Drug Manufacturers - ...
   (ENTA)1 Year Chart         ENTA Enanta Pharmaceuticals Inc 69 - $35.29 $3,832,000 75,357 0.05% 850,000 0 0.419    Biotechnology
   (EPZM)1 Year Chart         EPZM Epizyme, Inc. 70 - $24.41 $3,811,000 201,963 0.05% -1,991,000 -12,049 0.601    Biotechnology
   (CYTR)1 Year Chart         CYTR Cytrx Corp 71 - $3.27 $3,699,000 1,350,000 0.05% 270,000 0 4.43    Biotechnology
   (KPTI)1 Year Chart         KPTI Karyopharm Therapeutics Inc. 72 - $27.97 $3,522,000 94,095 0.05% 234,000 0 0.316    N/A
   (NDRM)1 Year Chart         NDRM Neuroderm Ltd New $13.97 $3,510,000 250,000 0.05% 3,510,000 250,000 2.778    N/A
   (CLTX)1 Year Chart         CLTX Celsus Therapeutics Plc. 73 - $0.93 $3,235,000 673,887 0.04% -876,000 0 12.12    N/A
   (ZGNX)1 Year Chart         ZGNX Zogenix, Inc. 74 - $1.74 $3,220,000 2,350,400 0.04% 517,000 0 2.181    Drug Manufacturers - ...
   (SGYP)1 Year Chart         SGYP Synergy Pharmaceuticals Inc... 75 - $3.21 $2,968,000 973,245 0.04% 258,000 0 1.079    N/A
   (RCPT)1 Year Chart         RCPT Receptos, Inc. 76 - $141.19 $2,928,000 23,900 0.04% 1,444,000 0 0.088    N/A
   (FMI)1 Year Chart         FMI Foundation Medicine, Inc. 77 - $46.97 $2,803,000 126,147 0.04% 1,321,000 47,985 0.461    N/A
   (SAGE)1 Year Chart         SAGE Sage Therapeutics, Inc. 78 - $0.00 $2,745,000 75,000 0.04% 382,000 0 0.291    N/A
   (MSTX)1 Year Chart         MSTX Mast Therapeutics Inc 79 - $0.54 $2,674,000 4,774,434 0.03% 1,003,000 1,774,434 4.648    Biotechnology
   (LPCN)1 Year Chart         LPCN Lipocine Inc 80 - $8.20 $2,630,000 500,000 0.03% -425,000 0 3.915    Conglomerates
   (AUPH)1 Year Chart         AUPH Aurinia Pharmaceuticals Inc 81 - $4.51 $2,599,000 727,669 0.03% 260,000 0 1.199    N/A
   (BDSI)1 Year Chart         BDSI Biodelivery Sciences Intern... 82 - $14.98 $2,524,000 210,021 0.03% -1,065,000 0 0.55    Drug Manufacturers - ...
   (AFMD)1 Year Chart         AFMD Affimed Nv - $6.01 $2,480,000 400,000 0.03% -40,000 0 1.668    N/A
   (BOTA)1 Year Chart         BOTA Nabi Biopharmaceuticals 83 - $2.40 $2,479,000 1,106,910 0.03% -255,000 0 3.903    Biotechnology
   (OSUR)1 Year Chart         OSUR Orasure Technologies Inc 84 - $7.11 $2,379,000 234,664 0.03% 685,000 0 0.422    Medical Instruments &...
   (MRNS)1 Year Chart         MRNS Marinus Pharmaceuticals Inc 85 - $0.00 $2,161,000 204,476 0.03% 838,000 0 1.46    N/A
   (DERM)1 Year Chart         DERM Dermira, Inc. 86 New $16.40 $1,811,000 100,000 0.02% 1,811,000 100,000 0.407    N/A
   (PRTO)1 Year Chart         PRTO Proteon Therapeutics Inc 87 New $10.39 $1,798,000 172,917 0.02% 1,798,000 172,917 1.051    N/A
   (OPHT)1 Year Chart         OPHT Ophthotech Corp. 88 - $53.48 $1,650,000 36,776 0.02% 218,000 0 0.118    N/A
   (MDWD)1 Year Chart         MDWD MediWound Ltd. 89 - $7.64 $1,499,000 225,000 0.02% 81,000 0 1.479    N/A
   (PTN)1 Year Chart         PTN Palatin Technologies Inc 90 New $1.05 $1,497,000 2,050,000 0.02% 1,497,000 2,050,000 5.231    Diagnostic Substances
   (SNTA)1 Year Chart         SNTA Synta Pharmaceuticals Corp 91 - $2.67 $1,325,000 500,000 0.02% -180,000 0 0.724    Diagnostic Substances
   (GERN)1 Year Chart         GERN Geron Corporation 92 - $3.78 $1,309,000 402,629 0.02% 504,000 0 0.312    Drug Manufacturers - ...
   (AKAO)1 Year Chart         AKAO Achaogen Inc 93 - $10.43 $1,305,000 100,000 0.02% 409,000 0 0.566    N/A
   (LOXO)1 Year Chart         LOXO Loxo Oncology, Inc. 94 - $0.00 $1,175,000 100,000 0.02% -138,000 0 0.601    N/A
   (TSRO)1 Year Chart         TSRO Tesaro, Inc. 95 - $55.21 $1,161,000 31,218 0.02% 321,000 0 0.087    Biotechnology
   (ALNY)1 Year Chart         ALNY Alnylam Pharmaceuticals Inc 96 - $111.56 $1,125,000 11,600 0.01% 219,000 0 0.018    Biotechnology
   (XLRN)1 Year Chart         XLRN Acceleron Pharma Inc 97 - $41.34 $1,121,000 28,765 0.01% 251,000 0 0.102    N/A

      100 Records Found
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