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  Name: BAKER BROS ADVISORS LLC
  City: NEW YORK
  State: NY
  Zip: 10021
   
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Portfolio Summary View Filing
  Filing Report Date : 2014-03-31
  Total Value : $5,946,371,000
  Total Value Change : $574,211,000
  Securities Held Change : 13
   
All Securities Held : 96
  New Positions : 18
  Closed Positions : 5
  Increased Positions : 21
  Unchanged Positions : 13
  Decreased Positions : 44
 
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Holdings Found : 99     View All Holdings Currently Viewing:  ALL     Page 1 of 1
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Ticker Company Name Position
Rank
New/Closed
Postion
Last
Close
    Value Shares Held
% of
Portfolio
Value
Change
Change In
Shares Held
   % of Company    Industry
   (SGEN)1 Year Chart         SGEN Seattle Genetics Inc 1 - $34.40 $944,887,000 20,739,426 15.89% 117,731,000 3,500 17.112    Biotechnology
   (GEVA)1 Year Chart         GEVA Synageva BioPharma Corp 2 - $69.30 $883,480,000 10,648,182 14.86% 218,600,000 375,000 34.64    Biotechnology
   (PCYC)1 Year Chart         PCYC Pharmacyclics Inc 3 - $108.50 $875,711,000 8,737,888 14.73% -46,608,000 18,670 12.866    Drug Manufacturers - ...
   (INCY)1 Year Chart         INCY Incyte Corp 4 - $47.14 $793,999,000 14,835,559 13.35% 44,140,000 25,000 9.208    Biotechnology
   (ACAD)1 Year Chart         ACAD Acadia Pharmaceuticals Inc 5 - $20.26 $498,313,000 20,481,442 8.38% -366,000 526,316 22.539    Biotechnology
   (GHDX)1 Year Chart         GHDX Genomic Health Inc 6 - $25.98 $359,650,000 13,654,150 6.05% -39,910,000 3,315 46.298    Biotechnology
   (ITMN)1 Year Chart         ITMN InterMune Inc 7 - $44.35 $144,752,000 4,324,843 2.43% 142,542,000 4,174,843 5.295    Drug Manufacturers - ...
   (BMRN)1 Year Chart         BMRN Biomarin Pharmaceutical Inc 8 - $60.01 $128,455,000 1,883,230 2.16% -8,116,000 -58,074 1.355    Drug Manufacturers - ...
   (XOMA)1 Year Chart         XOMA XOMA Corporation 9 - $3.85 $120,130,000 23,057,572 2.02% -34,878,000 25,200 24.772    Biotechnology
   (ICPT)1 Year Chart         ICPT Intercept Inc 10 - $223.99 $84,550,000 256,375 1.42% 59,775,000 -106,472 1.526    Biotechnology
   (HALO)1 Year Chart         HALO Halozyme Therapeutics Inc 11 - $8.91 $72,366,000 5,698,139 1.22% -22,026,000 -598,887 5.5    Biotechnology
   (VNDA)1 Year Chart         VNDA Vanda Pharmaceuticals Inc. 12 - $14.00 $72,243,000 4,445,696 1.21% 12,784,000 -345,483 13.395    Biotechnology
   (BCRX)1 Year Chart         BCRX Biocryst Pharmaceuticals Inc 13 - $11.74 $62,073,000 5,867,031 1.04% 11,153,000 -832,948 12.995    Biotechnology
   (ANAC)1 Year Chart         ANAC Anacor Pharmaceuticals Inc 14 - $16.36 $61,937,000 3,095,318 1.04% 19,987,000 595,318 7.631    Biotechnology
   (RPRX)1 Year Chart         RPRX Repros Therapeutics 15 - $13.99 $49,293,000 2,778,654 0.83% -1,556,000 0 12.079    Biotechnology
   (QCOR)1 Year Chart         QCOR Questcor Pharmaceuticals Inc 16 - $93.67 $46,603,000 717,745 0.78% 4,357,000 -58,119 1.13    Rental & Leasing Serv...
   (MRTX)1 Year Chart         MRTX Mirati Therapeutics, Inc. 17 - $17.84 $45,388,000 2,380,074 0.76% 5,807,000 0 17.656    Biotechnology
   (DSCI)1 Year Chart         DSCI Derma Sciences Inc 18 - $9.45 $44,851,000 3,537,137 0.75% 17,164,000 978,280 20.493    Drug Manufacturers - ...
   (CERS)1 Year Chart         CERS Cerus Corp 19 - $3.50 $40,585,000 8,455,306 0.68% -13,952,000 0 12    Biotechnology
   (GILD)1 Year Chart         GILD Gilead Sciences Inc 20 - $91.46 $39,406,000 556,108 0.66% -2,358,000 0 0.036    Biotechnology
   (ACOR)1 Year Chart         ACOR Acorda Therapeutics Inc 21 New $29.24 $37,910,000 1,000,000 0.64% 37,910,000 1,000,000 2.456    Biotechnology
   (CHTP)1 Year Chart         CHTP Chelsea Therapeutics Intern... 22 - $6.52 $37,317,000 6,760,394 0.63% 11,617,000 965,641 10.931    Biotechnology
   (CLVS)1 Year Chart         CLVS Clovis Oncology, Inc. 23 - $36.61 $36,712,000 529,990 0.62% 4,724,000 -748 1.757    Biotechnology
   (HRTX)1 Year Chart         HRTX Heron Therapeutics Inc 24 New $8.98 $30,153,000 2,167,784 0.51% 30,153,000 2,167,784 1.084    Synthetics
   (AEGR)1 Year Chart         AEGR Aegerion Pharmaceuticals, Inc. 25 - $30.07 $23,702,000 513,922 0.4% -11,778,000 13,922 1.783    Drug Manufacturers - ...
   (DYAX)1 Year Chart         DYAX DYAX Corp 26 - $8.55 $22,735,000 2,531,766 0.38% 7,465,000 505,229 2.092    Biotechnology
   (AVNR)1 Year Chart         AVNR Avanir Pharmaceuticals 27 - $5.20 $21,250,000 5,790,139 0.36% 3,010,000 361,548 4.662    Drug Manufacturers - ...
   (XNPT)1 Year Chart         XNPT Xenoport Inc 28 - $4.15 $20,856,000 4,034,112 0.35% 14,910,000 3,000,000 9.39    Drug Related Products
   (PGNX)1 Year Chart         PGNX Progenics Pharmaceuticals Inc 29 - $4.99 $18,200,000 4,449,797 0.31% -4,186,000 249,797 8.719    Drug Manufacturers - ...
   (AQXP)1 Year Chart         AQXP Aquinox Pharmaceuticals, Inc 30 New $8.00 $15,427,000 1,211,851 0.26% 15,427,000 1,211,851 12.07    N/A
   (TGTX)1 Year Chart         TGTX TG Therapeutics Inc 31 - $7.91 $14,911,000 2,160,965 0.25% 6,332,000 -38,691 6.451    Drug Manufacturers - ...
   (KYTH)1 Year Chart         KYTH Kythera Biopharmaceuticals Inc 32 - $34.37 $12,375,000 311,255 0.21% 677,000 -1,936 1.67    Drug Manufacturers - ...
   (ARWR)1 Year Chart         ARWR Arrowhead Research Corp 33 - $10.72 $12,020,000 732,062 0.2% -21,507,000 -2,357,938 2.321    Business Services
   (INSM)1 Year Chart         INSM Insmed Inc 34 - $17.10 $10,549,000 554,050 0.18% -2,989,000 -242,328 1.417    Biotechnology
   (TKMR)1 Year Chart         TKMR Tekmira Pharmaceuticals Corp 35 - $10.13 $10,405,000 484,156 0.17% 6,420,000 -15,844 3.991    N/A
   (SGMO)1 Year Chart         SGMO Sangamo Biosciences Inc 36 - $12.00 $9,452,000 522,764 0.16% 3,558,000 98,456 0.997    Biotechnology
   (SGYP)1 Year Chart         SGYP Synergy Pharmaceuticals Inc... 37 - $3.77 $9,336,000 1,758,271 0.16% -5,349,000 -850,000 2.734    N/A
   (OMER)1 Year Chart         OMER Omeros Corp 38 - $13.76 $9,098,000 753,804 0.15% 2,229,000 145,400 3.395    Drug Manufacturers - ...
   (PRTA)1 Year Chart         PRTA Prothena Corp Plc 39 - $17.37 $8,817,000 230,142 0.15% -118,000 -106,776 1.302    N/A
   (THLD)1 Year Chart         THLD Threshold Pharmaceuticals Inc 40 - $4.06 $8,693,000 1,826,358 0.15% 42,000 -26,041 3.742    Diagnostic Substances
   (QLTI)1 Year Chart         QLTI QLT Inc 41 - $5.45 $8,539,000 1,535,863 0.14% -16,000 0 3.075    Diagnostic Substances
   (DSCO)1 Year Chart         DSCO Discovery Laboratories Inc 42 - $1.59 $7,852,000 3,652,117 0.13% -515,000 -66,500 6.666    Biotechnology
   (AGIO)1 Year Chart         AGIO Agios Pharmaceuticals Inc 43 - $38.27 $7,826,000 199,893 0.13% 2,898,000 -5,857 0.641    N/A
   (GALT)1 Year Chart         GALT Galectin Therapeutics Inc 44 - $14.54 $7,655,000 500,000 0.13% 6,842,000 399,400 3.181    Drugs - Generic
   (INFI)1 Year Chart         INFI Infinity Pharmaceuticals Inc 45 - $9.27 $7,420,000 624,050 0.12% 7,420,000 624,050 1.301    Biotechnology
   (NBIX)1 Year Chart         NBIX Neurocrine Biosciences Inc 46 New $13.18 $7,211,000 447,874 0.12% 7,211,000 447,874 0.675    Biotechnology
   (STML)1 Year Chart         STML Stemline Therapeutics Inc 47 - $11.54 $6,895,000 338,671 0.12% -6,336,000 -336,371 2.905    N/A
   (AMBI)1 Year Chart         AMBI Ambit Biosciences Corp 48 - $5.38 $6,821,000 747,954 0.11% -389,000 0 0    Biotechnology
   (BOTA)1 Year Chart         BOTA Nabi Biopharmaceuticals 49 - $2.95 $6,763,000 1,106,910 0.11% 2,028,000 -23,203 2.581    Biotechnology
   (ARRY)1 Year Chart         ARRY Array Biopharma Inc 50 - $4.07 $6,739,000 1,433,797 0.11% -776,000 -66,203 1.225    Medical Laboratories ...
   (ZGNX)1 Year Chart         ZGNX Zogenix, Inc. 51 - $1.50 $6,687,000 2,350,400 0.11% -2,776,000 -400,600 2.335    Drug Manufacturers - ...
   (IDRA)1 Year Chart         IDRA Idera Pharmaceuticals Inc 52 - $2.56 $6,581,000 1,613,076 0.11% -8,104,000 -1,558,689 5.839    Biotechnology
   (XNCR)1 Year Chart         XNCR Xencor Inc 53 - $9.42 $6,362,000 542,363 0.11% 1,335,000 -7,637 1.729    Biotechnology
   (AERI)1 Year Chart         AERI Aerie Pharmaceuticals Inc 54 - $18.53 $6,343,000 299,356 0.11% 955,000 -644 1.286    Drug Manufacturers - ...
   (NVAX)1 Year Chart         NVAX Novavax Inc 55 - $4.29 $5,542,000 1,223,362 0.09% -1,047,000 -63,551 0.587    Biotechnology
   (IRWD)1 Year Chart         IRWD Ironwood Pharmaceuticals Inc 56 - $15.10 $5,497,000 446,160 0.09% -844,000 -100,000 0.367    Medical Laboratories ...
   (RGDO)1 Year Chart         RGDO Regado Biosciences Inc 57 New $2.91 $5,008,000 400,000 0.08% 5,008,000 400,000 0    N/A
   (LGND)1 Year Chart         LGND Ligand Pharmaceuticals Inc 58 - $48.08 $4,937,000 73,400 0.08% 1,076,000 0 0.359    Drug Manufacturers - ...
   (EPZM)1 Year Chart         EPZM Epizyme, Inc. 59 - $32.57 $4,873,000 214,012 0.08% 297,000 -5,988 0.753    Biotechnology
   (OSIR)1 Year Chart         OSIR Osiris Therapeutics, Inc. 60 - $14.50 $4,747,000 361,530 0.08% -1,288,000 -13,752 1.101    Biotechnology
   (PTLA)1 Year Chart         PTLA Portola Pharmaceuticals Inc 61 - $24.68 $4,729,000 182,591 0.08% -1,050,000 -41,843 0    Biotechnology
   (CYTR)1 Year Chart         CYTR Cytrx Corp 62 New $3.43 $4,712,000 1,350,000 0.08% 4,712,000 1,350,000 1.229    Biotechnology
   (BLUE)1 Year Chart         BLUE Bluebird Bio, Inc. 63 - $32.93 $4,508,000 198,260 0.08% 2,107,000 83,799 0.839    Biotechnology
   (CLTX)1 Year Chart         CLTX Celsus Therapeutics Plc. 64 New $5.85 $4,374,000 673,887 0.07% 4,374,000 673,887 12.12    N/A
   (RTRX)1 Year Chart         RTRX Retrophin Inc 65 New $10.86 $4,194,000 197,178 0.07% 4,194,000 197,178 1.073    N/A
   (ISIS)1 Year Chart         ISIS Isis Pharmaceuticals Inc 66 - $30.16 $4,161,000 96,303 0.07% -5,681,000 -150,733 0.083    Drug Manufacturers - ...
   (BDSI)1 Year Chart         BDSI Biodelivery Sciences Intern... 67 - $12.55 $3,553,000 421,005 0.06% -1,430,000 -425,000 1.424    Drug Manufacturers - ...
   (FURX)1 Year Chart         FURX Furiex Pharmaceuticals, Inc. 68 New $106.18 $3,507,000 40,309 0.06% 3,507,000 40,309 0.408    Drug Manufacturers - ...
   (ENTA)1 Year Chart         ENTA Enanta Pharmaceuticals Inc 69 - $38.74 $3,237,000 80,957 0.05% 261,000 -28,140 0    Biotechnology
   (MGNX)1 Year Chart         MGNX Macrogenics Inc 70 - $20.20 $2,676,000 96,165 0.05% -67,000 -3,835 0.382    Biotechnology
   (LJPC)1 Year Chart         LJPC La Jolla Pharmaceutical Co 71 New $11.80 $2,394,000 221,631 0.04% 2,394,000 221,631 0.41    Biotechnology
   (SNTA)1 Year Chart         SNTA Synta Pharmaceuticals Corp 72 - $4.02 $2,155,000 500,000 0.04% -465,000 0 0.724    Diagnostic Substances
   (MSTX)1 Year Chart         MSTX Mast Therapeutics Inc 73 New $0.58 $2,040,000 3,000,000 0.03% 2,040,000 3,000,000 2.921    Biotechnology
   (RIGL)1 Year Chart         RIGL Rigel Pharmaceuticals Inc 74 - $3.27 $1,870,000 481,972 0.03% 445,000 -18,028 1.054    Drug Manufacturers - ...
   (OSUR)1 Year Chart         OSUR Orasure Technologies Inc 75 - $8.09 $1,870,000 234,664 0.03% 339,000 -8,803 0    Medical Instruments &...
   (KPTI)1 Year Chart         KPTI Karyopharm Therapeutics Inc. 76 - $34.92 $1,825,000 59,095 0.03% 419,000 -2,235 0.199    N/A
   (AUXL)1 Year Chart         AUXL Auxilium Pharmaceuticals Inc 77 New $18.42 $1,591,000 58,544 0.03% 1,591,000 58,544 0.119    Drug Related Products
   (AKAO)1 Year Chart         AKAO Achaogen Inc 78 New $11.04 $1,546,000 100,000 0.03% 1,546,000 100,000 0.596    N/A
   (ACHN)1 Year Chart         ACHN Achillion Pharmaceuticals Inc 79 - $7.07 $1,442,000 438,337 0.02% -68,000 -16,663 0.454    Biotechnology
   (OPHT)1 Year Chart         OPHT Ophthotech Corp. 80 - $39.28 $1,314,000 36,776 0.02% -2,019,000 -66,264 0    N/A
   (CPRX)1 Year Chart         CPRX Catalyst Pharmaceutical Par... 81 New $2.34 $1,288,000 569,853 0.02% 1,288,000 569,853 0.849    Drugs - Generic
   (ZIOP)1 Year Chart         ZIOP Ziopharm Oncology Inc 82 - $3.09 $1,120,000 244,619 0.02% 17,000 -9,580 0.358    Biotechnology
   (RCPT)1 Year Chart         RCPT Receptos, Inc. 83 - $39.48 $1,002,000 23,900 0.02% -1,897,000 -76,100 0    N/A
   (FOLD)1 Year Chart         FOLD Amicus Therapeutics Inc 84 - $4.48 $997,000 481,697 0.02% -213,000 -33,375 1.392    Biotechnology
   (XLRN)1 Year Chart         XLRN Acceleron Pharma Inc 85 - $28.75 $992,000 28,765 0.02% -196,000 -1,235 0    N/A
   (TSRO)1 Year Chart         TSRO Tesaro, Inc. 86 - $27.83 $920,000 31,218 0.02% 38,000 0 0.115    Biotechnology
   (GERN)1 Year Chart         GERN Geron Corporation 87 - $2.53 $837,000 402,629 0.01% -1,071,000 0 0.306    Drug Manufacturers - ...
   (ALNY)1 Year Chart         ALNY Alnylam Pharmaceuticals Inc 88 New $53.31 $779,000 11,600 0.01% 779,000 11,600 0.019    Biotechnology
   (VTUS)1 Year Chart         VTUS Ventrus Biosciences Inc 89 - $1.44 $535,000 417,690 0.01% -4,110,000 -798,150 2.131    Drug Manufacturers - ...
   (QURE)1 Year Chart         QURE uniQure B.V. 90 New $10.19 $477,000 30,672 0.01% 477,000 30,672 0.267    N/A
   (FPRX)1 Year Chart         FPRX Five Prime Therapeutics Inc 91 - $12.32 $390,000 19,823 0.01% 57,000 0 0.1    Biotechnology
   (SLXP)1 Year Chart         SLXP Salix Pharmaceuticals Ltd 92 - $131.32 $375,000 3,621 0.01% 49,000 0 0.006    Drug Related Products
   (CCXI)1 Year Chart         CCXI Chemocentryx, Inc. 93 - $5.49 $332,000 50,000 0.01% 42,000 0 0.138    Biotechnology
   (CYCCP)1 Year Chart         CYCCP Cyclacel Pharmaceuticals, Inc 94 - $9.70 $113,000 13,253 0% -80,000 -7,726 0.082    Biotechnology
   (PBYI)1 Year Chart         PBYI Puma Biotechnology Inc 96 Closed $198.01 $0 0 0% -2,588,000 -25,000 0    N/A
   (MDVN)1 Year Chart         MDVN Medivation Inc 99 Closed $76.31 $0 0 0% -25,421,000 -398,331 0    Biotechnology
   (UTHR)1 Year Chart         UTHR United Therapeutics Corp 95 Closed $90.85 $0 0 0% -2,262,000 -20,000 0    Drug Manufacturers - ...
   (GWPH)1 Year Chart         GWPH Gw Pharmaceuticals Plc 98 Closed $84.51 $0 0 0% -3,912,000 -94,172 0    N/A
   (FMI)1 Year Chart         FMI Foundation Medicine, Inc. 97 Closed $23.67 $0 0 0% -476,000 -20,000 0    N/A

      99 Records Found
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