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  Name: BAKER BROS ADVISORS LLC
  City: NEW YORK
  State: NY
  Zip: 10021
   
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Portfolio Summary View Filing
  Filing Report Date : 2014-06-30
  Total Value : $6,173,752,000
  Total Value Change : $227,381,000
  Securities Held Change : -1
   
All Securities Held : 95
  New Positions : 6
  Closed Positions : 8
  Increased Positions : 23
  Unchanged Positions : 57
  Decreased Positions : 9
 
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Holdings Found : 100     View All Holdings Currently Viewing:  ALL     Page 1 of 1
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Ticker Company Name Position
Rank
New/Closed
Postion
Last
Close
    Value Shares Held
% of
Portfolio
Value
Change
Change In
Shares Held
   % of Company    Industry
   (GEVA)1 Year Chart         GEVA Synageva BioPharma Corp 1 - $72.22 $1,117,213,000 10,660,432 18.1% 233,733,000 12,250 31.354    Biotechnology
   (PCYC)1 Year Chart         PCYC Pharmacyclics Inc 2 - $120.40 $860,458,000 9,591,546 13.94% -15,253,000 853,658 13.035    Drug Manufacturers - ...
   (SGEN)1 Year Chart         SGEN Seattle Genetics Inc 3 - $42.99 $859,562,000 22,472,229 13.92% -85,325,000 1,732,803 18.123    Biotechnology
   (INCY)1 Year Chart         INCY Incyte Corp 4 - $51.66 $837,883,000 14,845,559 13.57% 43,884,000 10,000 9.228    Biotechnology
   (ACAD)1 Year Chart         ACAD Acadia Pharmaceuticals Inc 5 - $22.69 $462,676,000 20,481,442 7.49% -35,637,000 0 20.481    Biotechnology
   (GHDX)1 Year Chart         GHDX Genomic Health Inc 6 - $28.03 $374,144,000 13,654,902 6.06% 14,494,000 752 44.424    Biotechnology
   (ITMN)1 Year Chart         ITMN InterMune Inc 7 - $54.10 $208,515,000 4,722,869 3.38% 63,763,000 398,026 4.373    Drug Manufacturers - ...
   (BCRX)1 Year Chart         BCRX Biocryst Pharmaceuticals Inc 8 - $13.09 $138,859,000 10,890,872 2.25% 76,786,000 5,023,841 18.431    Biotechnology
   (BMRN)1 Year Chart         BMRN Biomarin Pharmaceutical Inc 9 - $70.66 $118,711,000 1,908,230 1.92% -9,744,000 25,000 1.289    Drug Manufacturers - ...
   (XOMA)1 Year Chart         XOMA XOMA Corporation 10 - $4.29 $105,873,000 23,065,972 1.71% -14,257,000 8,400 24.882    Biotechnology
   (AVNR)1 Year Chart         AVNR Avanir Pharmaceuticals 11 - $5.73 $104,670,000 18,558,487 1.7% 83,420,000 12,768,348 12.188    Drug Manufacturers - ...
   (VNDA)1 Year Chart         VNDA Vanda Pharmaceuticals Inc. 12 - $12.31 $70,741,000 4,372,153 1.15% -1,502,000 -73,543 11.156    Biotechnology
   (ANAC)1 Year Chart         ANAC Anacor Pharmaceuticals Inc 13 - $21.36 $57,588,000 3,248,043 0.93% -4,349,000 152,725 7.972    Biotechnology
   (DYAX)1 Year Chart         DYAX DYAX Corp 14 - $9.81 $54,540,000 5,681,237 0.88% 31,805,000 3,149,471 4.147    Biotechnology
   (RPRX)1 Year Chart         RPRX Repros Therapeutics 15 - $14.49 $48,071,000 2,778,654 0.78% -1,222,000 0 12.076    Biotechnology
   (MRTX)1 Year Chart         MRTX Mirati Therapeutics, Inc. 16 - $18.73 $47,601,000 2,380,074 0.77% 2,213,000 0 17.656    Biotechnology
   (QCOR)1 Year Chart         QCOR Questcor Pharmaceuticals Inc 17 - $93.60 $46,245,000 500,000 0.75% -358,000 -217,745 0.788    Rental & Leasing Serv...
   (CERS)1 Year Chart         CERS Cerus Corp 18 - $3.67 $42,523,000 10,246,591 0.69% 1,938,000 1,791,285 14.543    Biotechnology
   (DSCI)1 Year Chart         DSCI Derma Sciences Inc 19 - $8.69 $40,889,000 3,537,137 0.66% -3,962,000 0 14.047    Drug Manufacturers - ...
   (VSAR)1 Year Chart         VSAR Versartis, Inc. 20 New $20.00 $34,935,000 1,245,889 0.57% 34,935,000 1,245,889 5.356    N/A
   (CLVS)1 Year Chart         CLVS Clovis Oncology, Inc. 21 - $43.60 $32,847,000 793,221 0.53% -3,865,000 263,231 2.629    Biotechnology
   (HRTX)1 Year Chart         HRTX Heron Therapeutics Inc 22 - $8.95 $32,128,000 2,607,784 0.52% 1,975,000 440,000 1.304    Synthetics
   (ACOR)1 Year Chart         ACOR Acorda Therapeutics Inc 23 - $31.32 $30,544,000 906,091 0.49% -7,366,000 -93,909 2.157    Biotechnology
   (HALO)1 Year Chart         HALO Halozyme Therapeutics Inc 24 - $9.75 $27,428,000 2,776,143 0.44% -44,938,000 -2,921,996 2.436    Biotechnology
   (GILD)1 Year Chart         GILD Gilead Sciences Inc 25 - $100.79 $21,234,000 256,108 0.34% -18,172,000 -300,000 0.017    Biotechnology
   (ARWR)1 Year Chart         ARWR Arrowhead Research Corp 26 - $13.66 $20,475,000 1,430,802 0.33% 8,455,000 698,740 2.758    Business Services
   (TGTX)1 Year Chart         TGTX TG Therapeutics Inc 27 - $8.20 $20,291,000 2,160,965 0.33% 5,380,000 0 6.47    Drug Manufacturers - ...
   (XNPT)1 Year Chart         XNPT Xenoport Inc 28 - $4.84 $19,485,000 4,034,112 0.32% -1,371,000 0 6.518    Drug Related Products
   (PGNX)1 Year Chart         PGNX Progenics Pharmaceuticals Inc 29 - $5.18 $19,179,000 4,449,797 0.31% 979,000 0 7.316    Drug Manufacturers - ...
   (AEGR)1 Year Chart         AEGR Aegerion Pharmaceuticals, Inc. 30 - $31.09 $13,283,000 413,922 0.22% -10,419,000 -100,000 1.315    Drug Manufacturers - ...
   (OMER)1 Year Chart         OMER Omeros Corp 31 - $12.58 $13,116,000 753,804 0.21% 4,018,000 0 2.525    Drug Manufacturers - ...
   (KYTH)1 Year Chart         KYTH Kythera Biopharmaceuticals Inc 32 - $35.65 $11,943,000 311,255 0.19% -432,000 0 1.658    Drug Manufacturers - ...
   (AQXP)1 Year Chart         AQXP Aquinox Pharmaceuticals, Inc 33 - $6.55 $11,355,000 1,211,851 0.18% -4,072,000 0 12.07    N/A
   (QLTI)1 Year Chart         QLTI QLT Inc 34 - $5.30 $9,492,000 1,535,863 0.15% 953,000 0 3.007    Diagnostic Substances
   (AGIO)1 Year Chart         AGIO Agios Pharmaceuticals Inc 35 - $40.42 $9,159,000 199,893 0.15% 1,333,000 0 0.643    N/A
   (NBIX)1 Year Chart         NBIX Neurocrine Biosciences Inc 36 - $15.28 $8,230,000 554,590 0.13% 1,019,000 106,716 0.73    Biotechnology
   (SGMO)1 Year Chart         SGMO Sangamo Biosciences Inc 37 - $14.01 $7,983,000 522,764 0.13% -1,469,000 0 0.851    Biotechnology
   (OSIR)1 Year Chart         OSIR Osiris Therapeutics, Inc. 38 - $14.30 $7,976,000 510,606 0.13% 3,229,000 149,076 1.51    Biotechnology
   (INFI)1 Year Chart         INFI Infinity Pharmaceuticals Inc 39 - $10.94 $7,950,000 624,050 0.13% 530,000 0 1.298    Biotechnology
   (BLUE)1 Year Chart         BLUE Bluebird Bio, Inc. 40 - $36.89 $7,647,000 198,260 0.12% 3,139,000 0 0.839    Biotechnology
   (AERI)1 Year Chart         AERI Aerie Pharmaceuticals Inc 41 - $17.51 $7,415,000 299,356 0.12% 1,072,000 0 1.286    Drug Manufacturers - ...
   (THLD)1 Year Chart         THLD Threshold Pharmaceuticals Inc 42 - $4.08 $7,232,000 1,826,358 0.12% -1,461,000 0 3.086    Diagnostic Substances
   (SGYP)1 Year Chart         SGYP Synergy Pharmaceuticals Inc... 43 - $3.62 $7,156,000 1,758,271 0.12% -2,180,000 0 1.95    N/A
   (IRWD)1 Year Chart         IRWD Ironwood Pharmaceuticals Inc 44 - $13.11 $6,840,000 446,160 0.11% 1,343,000 0 0.319    Medical Laboratories ...
   (MGNX)1 Year Chart         MGNX Macrogenics Inc 45 - $20.18 $6,777,000 311,891 0.11% 4,101,000 215,726 1.238    Biotechnology
   (EPZM)1 Year Chart         EPZM Epizyme, Inc. 46 - $33.53 $6,660,000 214,012 0.11% 1,787,000 0 0.753    Biotechnology
   (ARRY)1 Year Chart         ARRY Array Biopharma Inc 47 - $3.83 $6,538,000 1,433,797 0.11% -201,000 0 1.149    Medical Laboratories ...
   (DSCO)1 Year Chart         DSCO Discovery Laboratories Inc 48 - $1.67 $6,501,000 3,652,117 0.11% -1,351,000 0 6.666    Biotechnology
   (TKMR)1 Year Chart         TKMR Tekmira Pharmaceuticals Corp 49 - $17.74 $6,323,000 484,156 0.1% -4,082,000 0 3.327    N/A
   (XNCR)1 Year Chart         XNCR Xencor Inc 50 - $9.84 $6,302,000 542,363 0.1% -60,000 0 1.729    Biotechnology
   (INSM)1 Year Chart         INSM Insmed Inc 51 - $13.45 $6,075,000 304,050 0.1% -4,474,000 -250,000 0.778    Biotechnology
   (NVAX)1 Year Chart         NVAX Novavax Inc 52 - $4.51 $5,652,000 1,223,362 0.09% 110,000 0 0.587    Biotechnology
   (CYTR)1 Year Chart         CYTR Cytrx Corp 53 - $3.18 $5,643,000 1,350,000 0.09% 931,000 0 4.43    Biotechnology
   (CPRX)1 Year Chart         CPRX Catalyst Pharmaceutical Par... 54 - $2.30 $5,624,000 2,223,053 0.09% 4,336,000 1,653,200 3.31    Drugs - Generic
   (RXDX)1 Year Chart         RXDX Ignyta, Inc. 55 - $7.58 $5,190,000 571,000 0.08% 451,000 0 2.916    N/A
   (AMBI)1 Year Chart         AMBI Ambit Biosciences Corp 56 - $5.99 $5,168,000 747,954 0.08% -1,653,000 0 4.184    Biotechnology
   (BDSI)1 Year Chart         BDSI Biodelivery Sciences Intern... 57 - $13.89 $5,082,000 421,005 0.08% 1,529,000 0 1.103    Drug Manufacturers - ...
   (STML)1 Year Chart         STML Stemline Therapeutics Inc 58 - $11.10 $4,968,000 338,671 0.08% -1,927,000 0 2.628    N/A
   (ZGNX)1 Year Chart         ZGNX Zogenix, Inc. 59 - $1.21 $4,724,000 2,350,400 0.08% -1,963,000 0 2.181    Drug Manufacturers - ...
   (IDRA)1 Year Chart         IDRA Idera Pharmaceuticals Inc 60 - $2.57 $4,678,000 1,613,076 0.08% -1,903,000 0 2.573    Biotechnology
   (LGND)1 Year Chart         LGND Ligand Pharmaceuticals Inc 61 - $54.17 $4,572,000 73,400 0.07% -365,000 0 0.359    Drug Manufacturers - ...
   (RARE)1 Year Chart         RARE Ultragenyx Pharmaceutical Inc 62 - $56.03 $4,489,000 100,000 0.07% -400,000 0 0.333    Restaurants
   (KPTI)1 Year Chart         KPTI Karyopharm Therapeutics Inc. 63 - $36.53 $4,380,000 94,095 0.07% 2,555,000 35,000 0.316    N/A
   (GALT)1 Year Chart         GALT Galectin Therapeutics Inc 64 - $5.08 $4,143,000 300,000 0.07% -3,512,000 -200,000 1.7    Drugs - Generic
   (CNCE)1 Year Chart         CNCE Concert Pharmaceuticals, Inc. 65 New $9.20 $4,028,000 398,800 0.07% 4,028,000 398,800 2.228    N/A
   (CLTX)1 Year Chart         CLTX Celsus Therapeutics Plc. 66 - $5.60 $3,706,000 673,887 0.06% -668,000 0 12.12    N/A
   (ISIS)1 Year Chart         ISIS Isis Pharmaceuticals Inc 67 - $35.28 $3,318,000 96,303 0.05% -843,000 0 0.536    Drug Manufacturers - ...
   (ACHN)1 Year Chart         ACHN Achillion Pharmaceuticals Inc 68 - $9.79 $3,318,000 438,337 0.05% 1,876,000 0 0    Biotechnology
   (ENTA)1 Year Chart         ENTA Enanta Pharmaceuticals Inc 69 - $39.70 $3,246,000 75,357 0.05% 9,000 -5,600 0.419    Biotechnology
   (BOTA)1 Year Chart         BOTA Nabi Biopharmaceuticals 70 - $2.43 $3,155,000 1,106,910 0.05% -3,608,000 0 3.903    Biotechnology
   (ALDR)1 Year Chart         ALDR Alder Biopharmaceuticals Inc 71 New $16.23 $3,078,000 153,350 0.05% 3,078,000 153,350 0.498    N/A
   (LPCN)1 Year Chart         LPCN Lipocine Inc 72 New $8.36 $3,050,000 500,000 0.05% 3,050,000 500,000 3.915    Conglomerates
   (RGDO)1 Year Chart         RGDO Regado Biosciences Inc 73 - $2.86 $2,716,000 400,000 0.04% -2,292,000 0 1.878    N/A
   (MDWD)1 Year Chart         MDWD MediWound Ltd. 74 New $7.06 $2,561,000 225,000 0.04% 2,561,000 225,000 1.479    N/A
   (FMI)1 Year Chart         FMI Foundation Medicine, Inc. 75 - $24.30 $2,107,000 78,162 0.03% 2,107,000 78,162 0.286    N/A
   (SNTA)1 Year Chart         SNTA Synta Pharmaceuticals Corp 76 - $4.07 $2,045,000 500,000 0.03% -110,000 0 0.724    Diagnostic Substances
   (LJPC)1 Year Chart         LJPC La Jolla Pharmaceutical Co 77 - $10.39 $2,035,000 221,631 0.03% -359,000 0 2.816    Biotechnology
   (OSUR)1 Year Chart         OSUR Orasure Technologies Inc 78 - $7.78 $2,020,000 234,664 0.03% 150,000 0 0.422    Medical Instruments &...
   (MSTX)1 Year Chart         MSTX Mast Therapeutics Inc 79 - $0.63 $1,887,000 3,000,000 0.03% -153,000 0 2.921    Biotechnology
   (RIGL)1 Year Chart         RIGL Rigel Pharmaceuticals Inc 80 - $2.63 $1,750,000 481,972 0.03% -120,000 0 0.551    Drug Manufacturers - ...
   (FOLD)1 Year Chart         FOLD Amicus Therapeutics Inc 81 - $5.50 $1,609,000 481,697 0.03% 612,000 0 0.971    Biotechnology
   (OPHT)1 Year Chart         OPHT Ophthotech Corp. 82 - $38.26 $1,556,000 36,776 0.03% 242,000 0 0.118    N/A
   (AKAO)1 Year Chart         AKAO Achaogen Inc 83 - $9.25 $1,396,000 100,000 0.02% -150,000 0 0.566    N/A
   (GERN)1 Year Chart         GERN Geron Corporation 84 - $2.36 $1,292,000 402,629 0.02% 455,000 0 0.312    Drug Manufacturers - ...
   (SLXP)1 Year Chart         SLXP Salix Pharmaceuticals Ltd 85 - $157.18 $1,063,000 8,621 0.02% 688,000 5,000 0.013    Drug Related Products
   (RCPT)1 Year Chart         RCPT Receptos, Inc. 86 - $46.60 $1,018,000 23,900 0.02% 16,000 0 0.088    N/A
   (ZIOP)1 Year Chart         ZIOP Ziopharm Oncology Inc 87 - $3.25 $986,000 244,619 0.02% -134,000 0 0.292    Biotechnology
   (XLRN)1 Year Chart         XLRN Acceleron Pharma Inc 88 - $27.71 $977,000 28,765 0.02% -15,000 0 0.102    N/A
   (TSRO)1 Year Chart         TSRO Tesaro, Inc. 89 - $29.76 $971,000 31,218 0.02% 51,000 0 0.095    Biotechnology
   (ALNY)1 Year Chart         ALNY Alnylam Pharmaceuticals Inc 90 - $67.33 $733,000 11,600 0.01% -46,000 0 0.018    Biotechnology
   (QURE)1 Year Chart         QURE uniQure B.V. 91 - $11.69 $417,000 30,672 0.01% -60,000 0 0.174    N/A
   (FPRX)1 Year Chart         FPRX Five Prime Therapeutics Inc 92 - $11.74 $308,000 19,823 0% -82,000 0 0.118    Biotechnology
   (CCXI)1 Year Chart         CCXI Chemocentryx, Inc. 93 - $5.01 $293,000 50,000 0% -39,000 0 0.117    Biotechnology
   (CYCCP)1 Year Chart         CYCCP Cyclacel Pharmaceuticals, Inc 94 - $7.50 $108,000 13,253 0% -5,000 0 0.082    Biotechnology
   (AUXL)1 Year Chart         AUXL Auxilium Pharmaceuticals Inc 99 Closed $17.77 $0 0 0% -1,591,000 -58,544 0    Drug Related Products
   (ICPT)1 Year Chart         ICPT Intercept Inc 98 Closed $284.09 $0 0 0% -84,550,000 -256,375 0    Biotechnology
   (PTLA)1 Year Chart         PTLA Portola Pharmaceuticals Inc 97 Closed $25.91 $0 0 0% -4,729,000 -182,591 0    Biotechnology
   (RTRX)1 Year Chart         RTRX Retrophin Inc 102 Closed $12.13 $0 0 0% -4,194,000 -197,178 0    N/A
   (FURX)1 Year Chart         FURX Furiex Pharmaceuticals, Inc. 96 Closed $106.18 $0 0 0% -3,507,000 -40,309 0    Drug Manufacturers - ...
   (ASMB)1 Year Chart         ASMB Assembly Biosciences Inc 101 Closed $6.67 $0 0 0% -535,000 -83,538 0    Drug Manufacturers - ...

      100 Records Found
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